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As an important marker of inflammation, the role of \u03b22-microglobulin (\u03b22M) in acute ischemic stroke is unclear. We investigated the relationship between serum \u03b22M and the risk of acute ischemic stroke (AIS). Patients with AIS (202 cases), intracerebral hemorrhage (ICH, 41 cases), and healthy controls (253 cases) were recruited. Clinical and biochemical characteristics were collected. We used three binary logistic regression models to evaluate the correlation of \u03b22M with the risk of AIS. Furthermore, we investigated the relationship between serum \u03b22M and the National Institute of Health Stroke Scale (NIHSS) score, the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) subtypes, and the Essen Stroke Risk Score (ESRS) in patients with AIS. Our results showed that serum \u03b22M levels in patients with AIS were much higher than those in patients with ICH and in the control subjects. Individuals with higher levels of \u03b22M had higher odds of AIS. Moreover, serum \u03b22M levels were significantly and positively correlated with ESRS. In addition, the levels of \u03b22M were varied with different subgroups of AIS (TOAST classification). Serum \u03b22M is highly associated with the risk of AIS.<\/jats:p>","DOI":"10.1038\/s41598-019-43370-9","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T06:04:46Z","timestamp":1556863486000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Serum beta2-microglobulin levels are highly associated with the risk of acute ischemic stroke"],"prefix":"10.1038","volume":"9","author":[{"given":"Sen","family":"Qun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuwan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,3]]},"reference":[{"key":"43370_CR1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.5527\/wjn.v4.i1.98","volume":"4","author":"A Zumrutdal","year":"2015","unstructured":"Zumrutdal, A. Role of beta2-microglobulin in uremic patients may be greater than originally suspected. World journal of nephrology 4, 98\u2013104, https:\/\/doi.org\/10.5527\/wjn.v4.i1.98 (2015).","journal-title":"World journal of nephrology"},{"key":"43370_CR2","doi-asserted-by":"publisher","first-page":"e72073","DOI":"10.1371\/journal.pone.0072073","volume":"8","author":"Z Stanga","year":"2013","unstructured":"Stanga, Z. et al. Factors other than the glomerular filtration rate that determine the serum beta-2-microglobulin level. PloS one 8, e72073, https:\/\/doi.org\/10.1371\/journal.pone.0072073 (2013).","journal-title":"PloS one"},{"key":"43370_CR3","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/nm.3926","volume":"21","author":"AJ Filiano","year":"2015","unstructured":"Filiano, A. J. & Kipnis, J. Breaking bad blood: beta2-microglobulin as a pro-aging factor in blood. 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