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In this study we analyzed sleep defects in a\n                    <jats:italic>Drosophila<\/jats:italic>\n                    model of HD and investigated whether disturbed sleep coincides with alterations in the molecular mechanism controlling circadian rhythm. To analyze sleep defects we recorded the daily activity of flies in 12:12\u2009hours light:dark entrainment and in regard to the underlying molecular mechanism measured circadian \u201cclock\u201d gene expression. In HD flies we observed reduced amount of sleep, sleep fragmentation and prolonged sleep latency. We found changes in gene expression patterns of both transcriptional feedback loops of circadian regulation. We detected prolonged expression of the core feedback loop components\n                    <jats:italic>period<\/jats:italic>\n                    and\n                    <jats:italic>timeless<\/jats:italic>\n                    , whilst the secondary feedback loop member\n                    <jats:italic>vrille<\/jats:italic>\n                    had lower expression rates in general. Our results show that the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    HD model recapitulates most of the sleep related symptoms reported in patients therefore it can be a potential tool to study the molecular background of sleep defects in HD. Altered expression of circadian \u201cclock\u201d genes suggests that disturbed sleep pattern in HD might be the consequence of disturbed circadian regulation.\n                  <\/jats:p>","DOI":"10.1038\/s41598-019-43612-w","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T06:59:00Z","timestamp":1557385140000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Mutant huntingtin disturbs circadian clock gene expression and sleep patterns in Drosophila"],"prefix":"10.1038","volume":"9","author":[{"given":"Anik\u00f3","family":"Farag\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00f3ra","family":"Zsindely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-626X","authenticated-orcid":false,"given":"L\u00e1szl\u00f3","family":"Bodai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"43612_CR1","doi-asserted-by":"publisher","first-page":"e148","DOI":"10.1038\/emm.2014.121","volume":"47","author":"ES Musiek","year":"2015","unstructured":"Musiek, E. 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