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However, progression of disease in female Cy\/+ rats, assessed in limited studies, is more heterogeneous and to date has failed to show development of the CKD-MBD phenotype, thus limiting their use as a practical model of progressive CKD-MBD. Animal and human studies suggest that estrogen may be protective against kidney disease in addition to its established protective effect on bone. Therefore, in this study, we aimed to determine the effect of ovariectomy (OVX) on the biochemical and skeletal manifestations of CKD-MBD in Cy\/+ female rats. We hypothesized that OVX would accelerate development of the biochemical and skeletal features of CKD-MBD in female Cy\/+ rats, similar to those seen in male Cy\/+ rats. Female Cy\/+ rats underwent OVX (n\u2009=\u20098) or Sham (n\u2009=\u20098) surgery at 15 weeks of age. Blood was collected every 5 weeks post-surgery until 35 weeks of age, when the rats underwent a 4-day metabolic balance, and the tibia and final blood were collected at the time of sacrifice. OVX produced the expected changes in trabecular and cortical parameters consistent with post-menopausal disease, and negative phosphorus balance compared with Sham. However, indicators of CKD-MBD were similar between OVX and Sham (similar kidney weight, plasma blood urea nitrogen, creatinine, creatinine clearance, phosphorus, calcium, parathyroid hormone, and no cortical porosity). Contrary to our hypothesis, OVX did not produce evidence of development of the CKD-MBD phenotype in female Cy\/+ rats.<\/jats:p>","DOI":"10.1038\/s41598-019-44415-9","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T06:03:45Z","timestamp":1559023425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of ovariectomy on the progression of chronic kidney disease-mineral bone disorder (CKD-MBD) in female Cy\/+ rats"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4225-372X","authenticated-orcid":false,"given":"Colby J.","family":"Vorland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Lachcik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Swallow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne E.","family":"Metzger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal X.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Moe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Hill Gallant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"44415_CR1","doi-asserted-by":"publisher","first-page":"e0158765","DOI":"10.1371\/journal.pone.0158765","volume":"11","author":"NR Hill","year":"2016","unstructured":"Hill, N. 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Pamela Lachcik has nothing to disclose. Elizabeth Swallow has nothing to disclose. Dr. Metzger has nothing to disclose. Dr. Allen has nothing to disclose. Dr. Chen has nothing to disclose. Dr. Moe reports grants from NIH, Veterans Administration, Chugai, Keryx, and personal fees from Amgen outside the submitted work. Dr. Hill Gallant reports grants from Women\u2019s Global Health Institute, Indiana Clinical and Translational Science Institute, National Institutes of Health\/National Institute of Diabetes, Digestive and Kidney Disorders, and American Society for Bone and Mineral Research during the conduct of the study; grants from Chugai Pharmaceuticals, Inc., and personal fees from Reylpsa, Inc., Tricida, Inc., and Sanofi outside the submitted work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"7936"}}