{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:51:10Z","timestamp":1792803070437,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K1709721"],"award-info":[{"award-number":["K1709721"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K1709721"],"award-info":[{"award-number":["K1709721"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K1709721"],"award-info":[{"award-number":["K1709721"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K1709721"],"award-info":[{"award-number":["K1709721"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K1709721"],"award-info":[{"award-number":["K1709721"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K1709721"],"award-info":[{"award-number":["K1709721"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Surveillance remains an important tool for timely outbreak detection and response. Many countries, including Korea, have established national infectious disease surveillance systems with clinical notification. We aimed to evaluate the National Health Insurance Claims-based Surveillance (NHICS) compared to conventional passive report-based National Infectious Diseases Surveillance (NIDS). Reported to claimed cases ratios (R\/C ratio) were evaluated from monthly notifiable disease cases captured by NIDS and NHICS. The relationships between 26 infectious diseases and each surveillance system were analysed using Pearson\u2019s correlation analysis and linear regression. There was an overall increase in R\/C ratio from 2010\u20132017 (0.37 to 0.78). In 22 infectious diseases, there was a correlation between NIDS and NHICS. Moreover, claim-based surveillance showed less fluctuating disease incidence rates than report-based surveillance for specific infectious diseases, such as varicella, mumps, and scarlet fever. However, for infectious diseases with episodic outbreaks or low incidence, it was difficult to assess NHICS usefulness. Claim-based surveillance is less affected by limitations of conventional report-based surveillance systems, such as reporting rate. Given delays in claim systems, a claim-based surveillance is expected to be complementary to conventional systems for the detection of various infectious diseases with the advancement of bio-information technology.<\/jats:p>","DOI":"10.1038\/s41598-019-45409-3","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T12:04:56Z","timestamp":1560945896000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Complementing conventional infectious disease surveillance with national health insurance claims data in the Republic of Korea"],"prefix":"10.1038","volume":"9","author":[{"given":"Jaehun","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyoung","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-3217","authenticated-orcid":false,"given":"Young-Jin","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungmin","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1543-4659","authenticated-orcid":false,"given":"Chang-gyo","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulwoo","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dun-Sol","family":"Go","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arim","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munkhzul","family":"Radnaabaatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Jun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"45409_CR1","doi-asserted-by":"crossref","unstructured":"Morse, S. S. Factors in the emergence of infectious diseases in Plagues and Politics (ed. Price-Smith, A. T). 8\u201326 (Springer, 2001).","DOI":"10.1057\/9780230524248_2"},{"key":"45409_CR2","first-page":"551","volume":"64","author":"SW Kim","year":"2017","unstructured":"Kim, S. W. et al. Risk factors for transmission of Middle East respiratory syndrome coronavirus infection during the 2015 outbreak in South Korea. Clin. Infect. Dis. 64, 551\u2013557 (2017).","journal-title":"Clin. Infect. Dis."},{"key":"45409_CR3","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/S0140-6736(16)30623-7","volume":"388","author":"SY Cho","year":"2016","unstructured":"Cho, S. Y. et al. MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study. Lancet. 388, 994\u20131001 (2016).","journal-title":"Lancet."},{"key":"45409_CR4","doi-asserted-by":"publisher","first-page":"e2015034","DOI":"10.4178\/epih\/e2015034","volume":"37","author":"KH Meng","year":"2015","unstructured":"Meng, K. H. A lesson learned from the MERS epidemic in Korea: an essay on MERS. Epidemiol. Health. 37, e2015034 (2015).","journal-title":"Epidemiol. Health."},{"key":"45409_CR5","doi-asserted-by":"crossref","unstructured":"Jamison, D. T. et al. Disease control priorities in developing countries. (World Bank Publications, 2006).","DOI":"10.1596\/978-0-8213-6179-5"},{"key":"45409_CR6","unstructured":"World Health Organization. National Passive Surveillance, http:\/\/www.who.int\/immunization\/monitoring_surveillance\/burden\/vpd\/surveillance_type\/passive\/en\/."},{"key":"45409_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3893-0","volume":"16","author":"J Choi","year":"2016","unstructured":"Choi, J., Cho, Y., Shim, E. & Woo, H. Web-based infectious disease surveillance systems and public health perspectives: a systematic review. BMC Public Health. 16, 1238 (2016).","journal-title":"BMC Public Health."},{"issue":"suppl_4","key":"45409_CR8","doi-asserted-by":"publisher","first-page":"S375","DOI":"10.1093\/infdis\/jiw400","volume":"214","author":"S Bansal","year":"2016","unstructured":"Bansal, S., Chowell, G., Simonsen, L., Vespignani, A. & Viboud, C. Big data for infectious disease surveillance and modeling. J. Infect. Dis. 214(suppl_4), S375\u2013379 (2016).","journal-title":"J. Infect. Dis."},{"issue":"suppl_4","key":"45409_CR9","doi-asserted-by":"publisher","first-page":"S380","DOI":"10.1093\/infdis\/jiw376","volume":"214","author":"L Simonsen","year":"2016","unstructured":"Simonsen, L., Gog, J. R., Olson, D. & Viboud, C. Infectious disease surveillance in the big data era: towards faster and locally relevant systems. J. Infect. Dis. 214(suppl_4), S380\u2013385 (2016).","journal-title":"J. Infect. Dis."},{"key":"45409_CR10","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1093\/rheumatology\/keh544","volume":"44","author":"YH Yang","year":"2005","unstructured":"Yang, Y. H. et al. A nationwide survey on epidemiological characteristics of childhood Henoch-Sch\u00f6nlein purpura in Taiwan. Rheumatology. 44, 618\u2013622 (2005).","journal-title":"Rheumatology."},{"key":"45409_CR11","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1097\/DCR.0000000000000876","volume":"60","author":"CM Shin","year":"2017","unstructured":"Shin, C. M. et al. Association Among Obesity, Metabolic Health, and the Risk for Colorectal Cancer in the General Population in Korea Using the National Health Insurance Service-National Sample Cohort. Dis. Colon Rectum. 60, 1192\u20131200 (2017).","journal-title":"Dis. Colon Rectum."},{"key":"45409_CR12","first-page":"45","volume":"84","author":"D Melnychuk","year":"1993","unstructured":"Melnychuk, D., Moride, Y. & Abenhaim, L. Monitoring of drug utilization in public health surveillance activities: a conceptual framework. Can. J. Public Health. 84, 45\u201349 (1993).","journal-title":"Can. J. Public Health."},{"key":"45409_CR13","doi-asserted-by":"publisher","first-page":"e0119551","DOI":"10.1371\/journal.pone.0119551","volume":"10","author":"E Poluzzi","year":"2015","unstructured":"Poluzzi, E. et al. Pro-arrhythmic potential of oral antihistamines (H1): combining adverse event reports with drug utilization data across Europe. PLoS One. 10, e0119551 (2015).","journal-title":"PLoS One."},{"key":"45409_CR14","unstructured":"Health Insurance Review and Assessment. History of Hira system, http:\/\/www.hira.or.kr\/dummy.do?pgmid=HIRAJ010000003000."},{"issue":"5","key":"45409_CR15","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1007\/s11096-018-0625-9","volume":"40","author":"JaeEun Han","year":"2018","unstructured":"Han, J., Ye, Y. M. & Lee, S. Epidemiology of drug hypersensitivity reactions using 6-year national health insurance claim data from Korea. Int. J. Clin. Pharm., https:\/\/doi.org\/10.1007\/s11096-018-0625-9 (2018).","journal-title":"International Journal of Clinical Pharmacy"},{"key":"45409_CR16","doi-asserted-by":"publisher","first-page":"e110650","DOI":"10.1371\/journal.pone.0110650","volume":"9","author":"BK Koo","year":"2014","unstructured":"Koo, B. K., Lee, C. H., Yang, B. R., Hwang, S. S. & Choi, N. K. The incidence and prevalence of diabetes mellitus and related atherosclerotic complications in Korea: a National Health Insurance Database Study. PLoS One. 9, e110650 (2014).","journal-title":"PLoS One."},{"key":"45409_CR17","unstructured":"Infectious Disease Control And Prevention Act [Enforcement Date 03 Jun 2017]. [Act No.14316, 02 Dec 2016. Partial Amendment]."},{"key":"45409_CR18","unstructured":"Acquired Immune Deficiency Syndrome Prevention Act [Enforcement Date 18 April 2017]. [Act No.14780, 5 April 2013, Partial Amendment]."},{"key":"45409_CR19","unstructured":"World Health Organization. International Statistical Classification of Diseases and Related Health Problems 10th Revision, http:\/\/apps.who.int\/classifications\/icd10\/browse\/2010\/en#\/."},{"key":"45409_CR20","first-page":"348","volume":"46","author":"JL Bernal","year":"2017","unstructured":"Bernal, J. L., Cummins, S. & Gasparrini, A. Interrupted time series regression for the evaluation of public health interventions: a tutorial. Int. J. Epidemiol. 46, 348\u2013355 (2017).","journal-title":"Int. J. Epidemiol."},{"key":"45409_CR21","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1016\/j.vaccine.2006.12.016","volume":"25","author":"HF Tan","year":"2007","unstructured":"Tan, H. F., Chang, C. K., Tseng, H. F. & Lin, W. Evaluation of the National Notifiable Disease Surveillance System in Taiwan: an example of varicella reporting. Vaccine. 25, 2630\u20132633 (2007).","journal-title":"Vaccine."},{"key":"45409_CR22","doi-asserted-by":"publisher","first-page":"668","DOI":"10.5124\/jkma.2016.59.9.668","volume":"59","author":"Y Kim","year":"2016","unstructured":"Kim, Y. Healthcare reform after MERS outbreak: progress to date and next steps. J. Korean Med. Assoc. 59, 668\u2013671 (2016).","journal-title":"J. Korean Med. Assoc."},{"key":"45409_CR23","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3201\/eid2401.171027","volume":"24","author":"JH Kim","year":"2018","unstructured":"Kim, J. H. & Cheong, H. K. Increasing Number of Scarlet Fever Cases, South Korea, 2011\u20132016. Emerg. Infect. Dis. 24, 172\u2013173 (2018).","journal-title":"Emerg. Infect. Dis."},{"key":"45409_CR24","doi-asserted-by":"publisher","first-page":"e125","DOI":"10.3346\/jkms.2018.33.e125","volume":"33","author":"JH Kim","year":"2018","unstructured":"Kim, J. H., Bae, W., Kim, J. & Hwang, E. S. An Urgent Need for Global Preparedness Against the Reemergence of \u201cForgotten\u201d Infectious Diseases in Korea. J. Korean Med. Sci. 33, e125 (2018).","journal-title":"J. Korean Med. Sci."},{"key":"45409_CR25","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.3346\/jkms.2016.31.12.1897","volume":"31","author":"YH Lee","year":"2016","unstructured":"Lee, Y. H. & Choe, Y. J. Effectiveness of Varicella Vaccination Program in Preventing Laboratory-Confirmed Cases in Children in Seoul, Korea. J. Korean Med. Sci. 31, 1897\u20131901 (2016).","journal-title":"J. Korean Med. Sci."},{"key":"45409_CR26","unstructured":"Korea Centers for Diseases Control and Prevention. Epidemiological Investigation of Infectious Diseases in Korea. Annual Report (2016)."},{"key":"45409_CR27","unstructured":"Korea Centers for Diseases Control and Prevention. Case Definitions for National Notifiable Infectious Diseases, http:\/\/www.cdc.go.kr\/CDC\/cms\/content\/mobile\/67\/77067_view.html."},{"key":"45409_CR28","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1086\/425000","volume":"39","author":"JI Tokars","year":"2004","unstructured":"Tokars, J. I. et al. The Changing Face of Surveillance for Health Care-Associated Infections. Clin. Infect. Dis. 39, 1347\u20131352 (2004).","journal-title":"Clin. Infect. Dis."},{"key":"45409_CR29","doi-asserted-by":"publisher","first-page":"e53","DOI":"10.3346\/jkms.2019.34.e53","volume":"34","author":"J Jung","year":"2019","unstructured":"Jung, J. et al. Epidemiologic impact of the Korean national immunization program on varicella incidence. J. Korean Med. Sci. 34, e53 (2019).","journal-title":"J. Korean Med. Sci."},{"key":"45409_CR30","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1089\/hs.2015.0067","volume":"14","author":"C Rhee","year":"2016","unstructured":"Rhee, C. et al. Syndromic Surveillance System for Korea\u2013US Joint Biosurveillance Portal: Design and Lessons Learned. Health Secur. 14, 152\u2013160 (2016).","journal-title":"Health Secur."},{"key":"45409_CR31","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.3201\/eid2109.150417","volume":"21","author":"CA Nelson","year":"2015","unstructured":"Nelson, C. A. et al. Incidence of Clinical-Diagnosed Lyme Disease, United States, 2005\u20132010. Emerg. Infect. Dis. 21, 1625\u20131631 (2015).","journal-title":"Emerg. Infect. Dis."},{"key":"45409_CR32","doi-asserted-by":"publisher","first-page":"e102429","DOI":"10.1371\/journal.pone.0102429","volume":"9","author":"C Viboud","year":"2014","unstructured":"Viboud, C. et al. Demonstrating the Use of High-Volume Electronic Medical Claims Data to Monitor Local and Regional Influenza Activity in the US. Plos One. 9, e102429 (2014).","journal-title":"Plos One."},{"key":"45409_CR33","doi-asserted-by":"publisher","first-page":"e1003635","DOI":"10.1371\/journal.pcbi.1003635","volume":"10","author":"JR Gog","year":"2014","unstructured":"Gog, J. R. et al. Spatial Transmission of 2009 Pandemic Influenza in the US. PLOS Comput. Biol. 10, e1003635 (2014).","journal-title":"PLOS Comput. Biol."},{"key":"45409_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-8-82","volume":"8","author":"H Kalies","year":"2008","unstructured":"Kalies, H., Redel, R., Varga, R., Tauscher, M. & von Kries, R. Vaccination coverage in children can be estimated from health insurance data. BMC Public Health. 8, 82 (2008).","journal-title":"BMC Public Health."},{"key":"45409_CR35","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1001\/jama.2017.13836","volume":"318","author":"C Rhee","year":"2017","unstructured":"Rhee, C. et al. Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009\u20132014. JAMA. 318, 13 (2017).","journal-title":"JAMA."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-45409-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-45409-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-45409-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T10:34:37Z","timestamp":1671273277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-45409-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,19]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["45409"],"URL":"https:\/\/doi.org\/10.1038\/s41598-019-45409-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,19]]},"assertion":[{"value":"10 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"8750"}}