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Over the years, experimental research has shown the crucial involvement of IL-17A to steer the protective immune response against <jats:italic>Giardia<\/jats:italic>. The development of the protective response, as reflected by a significant drop in cyst secretion, typically takes around 3 to 4 weeks. However, early-life infections often have a more chronic character lasting for several weeks or months. Therefore, the aim of the current study was to investigate the dynamics of a <jats:italic>Giardia muris<\/jats:italic> infection and the subsequent host immune response in neonatal mice infected 4 days after birth. The outcome of the study showed that a <jats:italic>G<\/jats:italic>. <jats:italic>muris<\/jats:italic> infection in pre-weaned mice failed to trigger a protective IL-17A response, which could explain the prolonged course of infection in comparison to older mice. Only after weaning, a protective intestinal immune response started to develop, characterized by an upregulation of IL-17A and Mbl2 and the secretion of parasite-specific IgA.<\/jats:p>","DOI":"10.1038\/s41598-019-45544-x","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T10:03:04Z","timestamp":1561024984000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice"],"prefix":"10.1038","volume":"9","author":[{"given":"Oonagh","family":"Paerewijck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brecht","family":"Maertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Gagnaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolien","family":"De Bosscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Geldhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"45544_CR1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.exppara.2009.03.001","volume":"124","author":"T Geurden","year":"2010","unstructured":"Geurden, T., Vercruysse, J. & Claerebout, E. 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