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Two hundred and sixty-four <jats:italic>Salmonella enterica<\/jats:italic> isolates recovered over a 16-year period (2000 to 2016) from the poultry and swine production chains, in Brazil, were investigated by whole-genome sequencing (WGS). Most international lineages belonging to 28 serovars, including, <jats:italic>S<\/jats:italic>. <jats:italic>enterica<\/jats:italic> serovars <jats:italic>S<\/jats:italic>. Schwarzengrund ST96, <jats:italic>S<\/jats:italic>. Typhimurium ST19, <jats:italic>S<\/jats:italic>. Minnesota ST548, <jats:italic>S<\/jats:italic>. Infantis ST32, <jats:italic>S<\/jats:italic>. Heidelberg ST15, <jats:italic>S<\/jats:italic>. Newport ST45, <jats:italic>S<\/jats:italic>. Brandenburg ST65 and <jats:italic>S<\/jats:italic>. Kentucky ST198 displayed MDR and virulent genetic backgrounds. In this regard, resistome analysis revealed presence of <jats:italic>qnrE1<\/jats:italic> (identified for the first time in <jats:italic>S<\/jats:italic>. Typhimurium from food chain), <jats:italic>qnrB19, qnrS1<\/jats:italic>, <jats:italic>bla<\/jats:italic><jats:sub>CTX-M-8<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>CTX-M-2<\/jats:sub> and <jats:italic>bla<\/jats:italic><jats:sub>CMY-2<\/jats:sub> genes, as well as <jats:italic>gyrA<\/jats:italic> mutations; whereas ColpVC, IncHI2A, IncHI2, IncFIA, Incl1, IncA\/C2, IncR, IncX1 and po111 plasmids were detected. In addition, phylogenetic analysis revealed multiple independent lineages such as <jats:italic>S<\/jats:italic>. <jats:italic>enterica<\/jats:italic> serovars <jats:italic>S<\/jats:italic>. Infantis, <jats:italic>S<\/jats:italic>. Schwarzengrund, <jats:italic>S<\/jats:italic>. Minnesota, <jats:italic>S<\/jats:italic>. Kentucky and <jats:italic>S<\/jats:italic>. Brandenburg. In brief, ocurrence and persistence of international lineages of <jats:italic>S<\/jats:italic>. <jats:italic>enterica<\/jats:italic> serovars in food production chain is supported by conserved genomes and wide virulome and resistome.<\/jats:p>","DOI":"10.1038\/s41598-019-45838-0","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T10:03:13Z","timestamp":1564480993000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Genomic Features of High-Priority Salmonella enterica Serovars Circulating in the Food Production Chain, Brazil, 2000\u20132016"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3787-1988","authenticated-orcid":false,"given":"Daniel F.","family":"Monte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0161-5800","authenticated-orcid":false,"given":"Nilton","family":"Lincopan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Berman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Cerdeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivaramu","family":"Keelara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula J.","family":"Fedorka-Cray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariza","family":"Landgraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,30]]},"reference":[{"key":"45838_CR1","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","volume":"18","author":"E Tacconelli","year":"2018","unstructured":"Tacconelli, E. et al. 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