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LEMMJ01 isolated from Antarctic soil does not belong to any of the nearest species identified in the RDP database. Under UV radiation (A, B and C wavebands) the survival fractions of\n                    <jats:italic>Microbacterium<\/jats:italic>\n                    sp. cells were much higher compared with wild-type\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    K12A15. Especially remarkable for an Antarctic bacterium, an expressive resistance against high UV-B doses was observed. The increased survival of DNA repair-proficient\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    grown overnight added of 0.1\u2009mg\/ml or 1\u2009mg\/ml of the whole pigment extract produced by\n                    <jats:italic>Microbacterium<\/jats:italic>\n                    sp. revealed that part of the resistance of\n                    <jats:italic>Microbacterium<\/jats:italic>\n                    sp. against UV-B radiation seems to be connected with photoprotection by its pigments. Scanning electron microscopy revealed that UV-A and UV-B ensued membrane alterations only in\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    . The APCI-MS fingerprints revealed the diagnostic ions for neurosporene (m\/z 580, 566, 522, 538, and 524) synergism for the first time in this bacterium by HPLC-MS\/MS analysis. Carotenoids also were devoid of phototoxicity and cytotoxicity effects in mouse cells and in human keratinocytes and fibroblasts.\n                  <\/jats:p>","DOI":"10.1038\/s41598-019-45840-6","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T06:02:56Z","timestamp":1562047376000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Carotenoids from UV-resistant Antarctic Microbacterium sp. LEMMJ01"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-8274","authenticated-orcid":false,"given":"Maria Cristina P. 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