{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:47:16Z","timestamp":1790704036470,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Quantitative high resolution computed tomography (HRCT) may objectively assess systemic sclerosis (SSc)-interstitial lung disease (ILD) extent, using three basic densitometric measures: mean lung attenuation (MLA), skewness, and kurtosis. This prospective study aimed to develop a composite index - computerized integrated index (CII) \u2013 that accounted for MLA, skewness, and kurtosis by means of Principal Component Analysis over HRCTs of 83 consecutive SSc subjects, thus eliminating redundancies. Correlations among CII, cardiopulmonary function and immune-inflammatory biomarkers (e.g. sIL-2R\u03b1 and CCL18 serum levels) were explored. ILD was detected in 47% of patients at visual HRCT assessment. These patients had worse CII values than patients without ILD. The CII correlated with lung function at both baseline and follow-up, and with sIL-2R\u03b1 and CCL18 serum levels. The best discriminating CII value for ILD was 0.1966 (AUC\u2009=\u20090.77; sensitivity\u2009=\u20090.81 [95%CI:0.68\u20130.92]; specificity\u2009=\u20090.66 [95%CI:0.52\u20130.80]). Thirty-four percent of patients without visual trace of ILD had a CII lower than 0.1966, and 67% of them had a diffusing lung capacity for CO &lt;80% of predicted. We showed that this new composite CT index for SSc-ILD assessment correlates with both lung function and immune-inflammatory parameters and could be sufficiently sensitive for capturing early lung density changes in visually ILD-free patients.<\/jats:p>","DOI":"10.1038\/s41598-019-45990-7","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T10:02:54Z","timestamp":1561975374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Performance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis"],"prefix":"10.1038","volume":"9","author":[{"given":"Marialuisa","family":"Bocchino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Bruzzese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"D\u2019Alto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Argiento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9381-6660","authenticated-orcid":false,"given":"Alessia","family":"Borgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Capaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Romeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sanduzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullio","family":"Valente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Sverzellati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Rea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-9829","authenticated-orcid":false,"given":"Serena","family":"Vettori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"45990_CR1","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1136\/ard.2009.114264","volume":"69","author":"AJ Tyndall","year":"2010","unstructured":"Tyndall, A. J. et al. Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann Rheum Dis. 69, 1809\u20131815 (2010).","journal-title":"Ann Rheum Dis."},{"key":"45990_CR2","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1136\/ard.2006.066068","volume":"66","author":"VD Steen","year":"2007","unstructured":"Steen, V. D. & Medsger, T. A. Changes in causes of death in systemic sclerosis. Ann Rheum Dis. 66, 940\u2013944 (2007).","journal-title":"Ann Rheum Dis."},{"key":"45990_CR3","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nrrheum.2010.102","volume":"6","author":"M Trojanowska","year":"2010","unstructured":"Trojanowska, M. Cellular and molecular aspects of vascular dysfunction in systemic sclerosis. Nat Rev Rheumatol. 6, 653\u2013660 (2010).","journal-title":"Nat Rev Rheumatol."},{"key":"45990_CR4","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1056\/NEJMra0806188","volume":"360","author":"A Gabrielli","year":"2009","unstructured":"Gabrielli, A., Avvedimento, E. V. & Krieg, T. Scleroderma. N Engl J Med. 360, 1989\u20132003 (2009).","journal-title":"N Engl J Med."},{"key":"45990_CR5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s11926-012-0297-8","volume":"15","author":"MB Greenblatt","year":"2013","unstructured":"Greenblatt, M. B. & Aliprantis, A. O. The immune pathogenesis of scleroderma: context is everything. Curr Rheumatol Rep. 15, 297 (2013).","journal-title":"Curr Rheumatol Rep."},{"key":"45990_CR6","first-page":"1520","volume":"18","author":"JH Warrick","year":"1991","unstructured":"Warrick, J. H., Bhalla, M., Schabel, S. I. & Silver, R. M. High resolution computed tomography in early scleroderma lung disease. J Rheumatol. 18, 1520\u20131528 (1991).","journal-title":"J Rheumatol."},{"key":"45990_CR7","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1378\/chest.07-2444","volume":"134","author":"JG Goldin","year":"2008","unstructured":"Goldin, J. G. et al. Scleroderma Lung Study Research Group. High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung disease. Chest. 134, 358\u2013367 (2008).","journal-title":"Chest."},{"key":"45990_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1097\/RHU.0b013e318261176f","volume":"18","author":"S Patiwetwitoon","year":"2012","unstructured":"Patiwetwitoon, S., Wangkaew, S., Euathrongchit, J., Kasitanon, N. & Louthrenoo, W. High-resolution computed tomographic findings in systemic sclerosis-associated interstitial lung disease: comparison between diffuse and limited systemic sclerosis. J Clin Rheumatol. 18, 229\u2013233 (2012).","journal-title":"J Clin Rheumatol."},{"key":"45990_CR9","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1164\/rccm.200706-877OC","volume":"177","author":"NS Goh","year":"2008","unstructured":"Goh, N. S. et al. Interstitial lung disease in systemic sclerosis: a simple staging system. Am J Respir Crit Care Med. 177, 1248\u20131254 (2008).","journal-title":"Am J Respir Crit Care Med."},{"key":"45990_CR10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/rheumatology\/kes289","volume":"52","author":"OA Moore","year":"2013","unstructured":"Moore, O. A. et al. Extent of disease on high-resolution computed tomography lung is a predictor of decline and mortality in systemic sclerosis-related interstitial lung disease. Rheumatology (Oxford). 52, 155\u2013160 (2013).","journal-title":"Rheumatology (Oxford)."},{"key":"45990_CR11","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1002\/art.39166","volume":"67","author":"AM Hoffmann-Vold","year":"2015","unstructured":"Hoffmann-Vold, A. M. et al. Predictive value of serial high-resolution computed tomography analyses and concurrent lung function tests in systemic sclerosis. Arthritis Rheumatol. 67, 2205\u20132212 (2015).","journal-title":"Arthritis Rheumatol."},{"key":"45990_CR12","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.2214\/AJR.07.3177","volume":"191","author":"B Sundaram","year":"2008","unstructured":"Sundaram, B. et al. Accuracy of high-resolution CT in the diagnosis of diffuse lung disease: effect of predominance and distribution of findings. Am J Roentgenol. 191, 1032\u20131039 (2008).","journal-title":"Am J Roentgenol."},{"key":"45990_CR13","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1148\/radiol.12112516","volume":"266","author":"T Watadani","year":"2013","unstructured":"Watadani, T. et al. Interobserver variability in the CT assessment of honeycombing in the lungs. Radiology. 266, 936\u2013944 (2013).","journal-title":"Radiology."},{"key":"45990_CR14","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1152\/jappl.1994.76.1.271","volume":"76","author":"PG Hartley","year":"1994","unstructured":"Hartley, P. G. et al. High resolution CT-derived measures of lung density are valid indexes of interstitial lung disease. J Appl Physiol. 76, 271\u20137 (1994).","journal-title":"J Appl Physiol."},{"key":"45990_CR15","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1378\/chest.06-1401","volume":"131","author":"G Camiciottoli","year":"2007","unstructured":"Camiciottoli, G. et al. Lung CT densitometry in systemic sclerosis: correlation with lung function, exercise testing, and quality of life. Chest. 131, 672\u2013681 (2007).","journal-title":"Chest."},{"key":"45990_CR16","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00296-013-2845-6","volume":"34","author":"A Ariani","year":"2014","unstructured":"Ariani, A. et al. Utility of an open-source DICOM viewer software (OsiriX) to assess pulmonary fibrosis in systemic sclerosis: preliminary results. Rheumatol Int. 34, 511\u2013516 (2014).","journal-title":"Rheumatol Int."},{"key":"45990_CR17","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3109\/14397595.2015.1016200","volume":"25","author":"A Ariani","year":"2015","unstructured":"Ariani, A. et al. Operator-independent quantitative chest computed tomography versus standard assessment of interstitial lung disease related to systemic sclerosis: A multi-centric study. Mod Rheumatol. 25, 724\u2013730 (2015).","journal-title":"Mod Rheumatol."},{"key":"45990_CR18","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1111\/crj.12451","volume":"11","author":"A Ariani","year":"2017","unstructured":"Ariani, A. et al. Quantitative CT indexes are significantly associated with exercise oxygen desaturation in interstitial lung disease related to systemic sclerosis. Clin Respir J. 11, 983\u2013989 (2017).","journal-title":"Clin Respir J."},{"key":"45990_CR19","first-page":"69","volume":"19","author":"YJ Lee","year":"2001","unstructured":"Lee, Y. J. et al. Type III procollagen N-terminal propeptide, soluble interleukin-2 receptor, and von Willebrand factor in systemic sclerosis. Clin Exp Rheumatol. 19, 69\u201374 (2001).","journal-title":"Clin Exp Rheumatol."},{"key":"45990_CR20","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/art.1780330310","volume":"33","author":"D Degiannis","year":"1990","unstructured":"Degiannis, D., Seibold, J. R., Czarnecki, M., Raskova, J. & Raska, K. Jr. Soluble interleukin-2 receptors in systemic sclerosis patients. Arthritis Rheum. 33, 375\u2013380 (1990).","journal-title":"Arthritis Rheum."},{"key":"45990_CR21","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1183\/09031936.00131713","volume":"43","author":"J Schupp","year":"2014","unstructured":"Schupp, J. et al. Serum CCL18 is predictive for lung disease progression and mortality in systemic sclerosis. Eur Respir J. 43, 1530\u20131532 (2014).","journal-title":"Eur Respir J."},{"key":"45990_CR22","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.chest.2016.03.004","volume":"150","author":"AM Hoffmann-Vold","year":"2016","unstructured":"Hoffmann-Vold, A. M. et al. High level of chemokine CCL18 is associated with pulmonary function deterioration, lung fibrosis progression, and reduced survival in systemic sclerosis. Chest. 150, 299\u2013306 (2016).","journal-title":"Chest."},{"key":"45990_CR23","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/art.38098","volume":"65","author":"F van den Hoogen","year":"2013","unstructured":"van den Hoogen, F. et al. 2013 Classification criteria for systemic sclerosis: an American College of Rheumatology\/European League Against Rheumatism Collaborative Initiative. Arthritis Rheumatol. 65, 2737\u20132747 (2013).","journal-title":"Arthritis Rheumatol."},{"key":"45990_CR24","first-page":"202","volume":"15","author":"EC LeRoy","year":"1988","unstructured":"LeRoy, E. C. et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol. 15, 202\u2013205 (1988).","journal-title":"J Rheumatol."},{"issue":"3 Suppl 29","key":"45990_CR25","first-page":"S47","volume":"21","author":"G Valentini","year":"2003","unstructured":"Valentini, G., Medsger, T. A. Jr., Silman, A. J. & Bombardieri, S. Conclusion and identification of the core set of variables to be used in clinical investigations. Clin Exp Rheumatol. 21(3 Suppl 29), S47\u201348 (2003).","journal-title":"Clin Exp Rheumatol."},{"key":"45990_CR26","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s10875-014-0037-0","volume":"34","author":"S Vettori","year":"2014","unstructured":"Vettori, S. et al. Early systemic sclerosis: serum profiling of factors involved in endothelial, T-cell, and fibroblast interplay is marked by elevated interleukin-33 levels. J Clin Immunol. 34, 663\u2013668 (2014).","journal-title":"J Clin Immunol."},{"key":"45990_CR27","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1183\/09031936.05.00034805","volume":"26","author":"MR Miller","year":"2005","unstructured":"Miller, M. R. et al. ATS\/ERS Task Force. Standardization of spirometry. Eur Respir J. 26, 319\u2013338 (2005).","journal-title":"Eur Respir J."},{"key":"45990_CR28","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1183\/09031936.05.00035005","volume":"26","author":"J Wanger","year":"2005","unstructured":"Wanger, J. et al. Standardization of the measurement of lung volumes. Eur Respir J. 26, 511\u2013522 (2005).","journal-title":"Eur Respir J."},{"key":"45990_CR29","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1183\/09031936.05.00034905","volume":"26","author":"N Macintyre","year":"2005","unstructured":"Macintyre, N. et al. Standardization of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J. 26, 720\u2013735 (2005).","journal-title":"Eur Respir J."},{"key":"45990_CR30","doi-asserted-by":"crossref","unstructured":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 166, 111\u2013117 (2002).","DOI":"10.1164\/ajrccm.166.1.at1102"},{"issue":"5","key":"45990_CR31","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.semarthrit.2013.10.004","volume":"43","author":"Michele D\u2019Alto","year":"2014","unstructured":"D\u2019Alto, M. et al. Tissue Doppler imaging in systemic sclerosis: a 3-year longitudinal study. Semin Arthritis Rheum. 43, 673\u2013680 (2014).","journal-title":"Seminars in Arthritis and Rheumatism"},{"key":"45990_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","volume":"28","author":"RM Lang","year":"2015","unstructured":"Lang, R. M. et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 28, 1\u201339 (2015).","journal-title":"J Am Soc Echocardiogr."},{"key":"45990_CR33","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1148\/radiology.180.2.2068303","volume":"180","author":"CV Zwirewich","year":"1991","unstructured":"Zwirewich, C. V., Mayo, J. R. & Muller, N. L. Low-dose high-resolution CT of the lung parenchyma. Radiology. 180, 413\u2013417 (1991).","journal-title":"Radiology."},{"key":"45990_CR34","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1148\/radiology.191.3.8184044","volume":"191","author":"KS Lee","year":"1994","unstructured":"Lee, K. S. et al. Chronic infiltrative lung disease: comparison of diagnostic accuracies of radiography and low- and conventional-dose thin section CT. Radiology. 191, 669\u2013673 (1994).","journal-title":"Radiology."},{"key":"45990_CR35","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1148\/radiol.2323030899","volume":"232","author":"JR Mayo","year":"2004","unstructured":"Mayo, J. R. et al. Reduced radiation dose helical chest CT: effect on reader evaluation of structures and lung findings. Radiology. 232, 749\u2013756 (2004).","journal-title":"Radiology."},{"key":"45990_CR36","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1148\/radiol.2282020274","volume":"228","author":"AC Best","year":"2003","unstructured":"Best, A. C. et al. Quantitative CT indexes in idiopathic pulmonary fibrosis: relationship with physiologic impairment. Radiology. 228, 407\u2013414 (2003).","journal-title":"Radiology."},{"key":"45990_CR37","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1198\/016214504000001745","volume":"100","author":"F Yao","year":"2005","unstructured":"Yao, F., M\u00fcller, H. G. & Wang, J. L. Functional data analysis for sparse longitudinal data. J Am Stat Assoc. 100, 577\u2013590 (2005).","journal-title":"J Am Stat Assoc."},{"key":"45990_CR38","doi-asserted-by":"publisher","first-page":"255","DOI":"10.2307\/2532051","volume":"45","author":"I Lawrence","year":"1989","unstructured":"Lawrence, I. & Kuei, L. A concordance correlation coefficient to evaluate reproducibility. Biometrics. 45, 255\u2013268 (1989).","journal-title":"Biometrics."},{"key":"45990_CR39","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1136\/annrheumdis-2014-206076","volume":"75","author":"DP Tashkin","year":"2016","unstructured":"Tashkin, D. P. et al. Relationship between quantitative radiographic assessments of interstitial lung disease and physiological and clinical features of systemic sclerosis. Ann Rheum Dis. 75, 374\u2013381 (2016).","journal-title":"Ann Rheum Dis."},{"key":"45990_CR40","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1164\/rccm.201506-1063ST","volume":"192","author":"G Raghu","year":"2015","unstructured":"Raghu, G. et al. An Official ATS\/ERS\/JRS\/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline. Am J Respir Crit Care Med. 192, e3\u2013e19 (2015).","journal-title":"Am J Respir Crit Care Med."},{"key":"45990_CR41","doi-asserted-by":"publisher","first-page":"R166","DOI":"10.1186\/ar3125","volume":"12","author":"S Assassi","year":"2010","unstructured":"Assassi, S. et al. Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort. Arthritis Res Ther. 12, R166 (2010).","journal-title":"Arthritis Res Ther."},{"key":"45990_CR42","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1002\/art.38390","volume":"66","author":"SI Nihtyanova","year":"2014","unstructured":"Nihtyanova, S. I. et al. Prediction of pulmonary complications and long-term survival in systemic sclerosis. Arthritis Rheumatol. 66, 1625\u20131635 (2014).","journal-title":"Arthritis Rheumatol."},{"key":"45990_CR43","doi-asserted-by":"publisher","first-page":"3078","DOI":"10.1002\/art.30467","volume":"63","author":"D Khanna","year":"2011","unstructured":"Khanna, D. et al. Clinical course of lung physiology in patients with Scleroderma and Interstitial Lung Disease. Analysis of the Scleroderma Lung Study placebo group. Arthritis Rheum. 63, 3078\u20133085 (2011).","journal-title":"Arthritis Rheum."},{"key":"45990_CR44","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1093\/rheumatology\/kew480","volume":"56","author":"A Ariani","year":"2017","unstructured":"Ariani, A. et al. Quantitative chest computed tomography is associated with two prediction models of mortality in interstitial lung disease related to systemic sclerosis. Rheumatology. 56, 922\u2013927 (2017).","journal-title":"Rheumatology."},{"key":"45990_CR45","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12931-019-0980-7","volume":"20","author":"V Cottin","year":"2019","unstructured":"Cottin, V. & Brown, K. K. Interstitial lung disease associated with systemic sclerosis (SSc-ILD). Respir Res. 20, 13 (2019).","journal-title":"Respir Res."},{"key":"45990_CR46","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1097\/BOR.0000000000000592","volume":"31","author":"D Roofeh","year":"2019","unstructured":"Roofeh, D., Jaafar, S., Vummidi, D. & Khanna, D. Management of systemic sclerosis-associated interstitial lung disease. Curr Opin Rheumatol. 31, 241\u2013249 (2019).","journal-title":"Curr Opin Rheumatol."},{"key":"45990_CR47","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ejrad.2018.01.024","volume":"101","author":"C Kloth","year":"2018","unstructured":"Kloth, C. et al. Chest CT texture analysis for response assessment in systemic sclerosis. Eur J Radiol. 101, 50\u201358 (2018).","journal-title":"Eur J Radiol."},{"key":"45990_CR48","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1016\/j.acra.2017.07.002","volume":"24","author":"C Kloth","year":"2017","unstructured":"Kloth, C. et al. Differences in texture analysis parameters between active alveolitis and lung fibrosis in chest CT of patients with systemic sclerosis: a feasibility study. Acad Radiol. 24, 1596\u20131603 (2017).","journal-title":"Acad Radiol."},{"key":"45990_CR49","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ejrad.2019.01.024","volume":"112","author":"FS van Royen","year":"2019","unstructured":"van Royen, F. S. et al. Automated CT quantification methods for the assessment of interstitial lung disease in collagen vascular diseases: A systematic review. Eur J Radiol. 112, 200\u2013206 (2019).","journal-title":"Eur J Radiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-45990-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-45990-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-45990-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T11:02:10Z","timestamp":1671274930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-45990-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["45990"],"URL":"https:\/\/doi.org\/10.1038\/s41598-019-45990-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,1]]},"assertion":[{"value":"28 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"9468"}}