{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T05:27:36Z","timestamp":1782019656845,"version":"3.54.5"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study examined the relationship between biomechanical features of the pharyngoesophageal (PE) segment, acoustic characteristics of tracheoesophageal (TE) phonation, and patients\u2019 satisfaction with TE phonation. Fifteen patients using TE phonation after total laryngectomy completed the Voice Symptom Scale (VoiSS) and underwent acoustic voice analysis for cepstral peak prominence (CPP) and relative intensity. High resolution manometry (HRM) combined with videofluoroscopy was used to evaluate PE segment pressure and calculate the pressure gradient (\u0394P), which was the pressure difference between the upper oesophagus and a point two centimetres above the vibrating PE segment. The upper oesophageal sphincter (UOS) minimal diameters were measured by Endolumenal Functional Lumen Imaging Probe (EndoFLIP). HRM detected rapid pressure changes at the level of the 4th \u2013 6th cervical vertebra. CPP, relative intensity, and \u0394P were significant predictors of satisfactory TE phonation. \u0394P was a significant predictor of CPP and intensity. Minimal UOS diameter was a significant predictor of relative intensity of TE phonation. In two patients with unsuccessful TE phonation, endoscopic dilatation subsequently restored TE phonation. These findings suggest that sufficient \u0394P and large UOS diameter are required for satisfactory TE phonation. Endoscopic dilatation increasing UOS diameter may provide a new approach to treat unsuccessful TE phonation.<\/jats:p>","DOI":"10.1038\/s41598-019-46223-7","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T10:03:06Z","timestamp":1562320986000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The relationship between biomechanics of pharyngoesophageal segment and tracheoesophageal phonation"],"prefix":"10.1038","volume":"9","author":[{"given":"Teng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-8373","authenticated-orcid":false,"given":"Micha\u0142","family":"Szcz\u0119\u015bniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Maclean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-8938","authenticated-orcid":false,"given":"Duong Duy","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Madill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"46223_CR1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1121\/1.428324","volume":"107","author":"IR Titze","year":"2000","unstructured":"Titze, I. R. et al. Comparison between electroglottography and electromagnetic glottography. J Acoust Soc Am 107, 581\u2013588 (2000).","journal-title":"J Acoust Soc Am"},{"key":"46223_CR2","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1121\/1.395910","volume":"83","author":"IR Titze","year":"1988","unstructured":"Titze, I. R. The physics of small-amplitude oscillation of the vocal folds. J Acoust Soc Am 83, 1536\u20131552 (1988).","journal-title":"J Acoust Soc Am"},{"key":"46223_CR3","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1109\/TBME.2002.800755","volume":"49","author":"M Dollinger","year":"2002","unstructured":"Dollinger, M. et al. Vibration parameter extraction from endoscopic image series of the vocal folds. IEEE Trans. Biomed. Eng. 49, 773\u2013781 (2002).","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"46223_CR4","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/1460-6984.12148","volume":"50","author":"A Perry","year":"2015","unstructured":"Perry, A., Casey, E. & Cotton, S. Quality of life after total laryngectomy: functioning, psychological well-being and self-efficacy. Int J Lang Commun Disord 50, 467\u2013475 (2015).","journal-title":"Int J Lang Commun Disord"},{"key":"46223_CR5","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1288\/00005537-199510000-00016","volume":"105","author":"ED Blom","year":"1995","unstructured":"Blom, E. D., Pauloski, B. R. & Hamaker, R. C. Functional outcome after surgery for prevention of pharyngospasms in tracheoesophageal speakers. Part I: Speech characteristics. Laryngoscope 105, 1093\u20131103 (1995).","journal-title":"Laryngoscope"},{"key":"46223_CR6","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1001\/archotol.1994.01880300062009","volume":"120","author":"K Omori","year":"1994","unstructured":"Omori, K., Kojima, H., Nonomura, M. & Fukushima, H. Mechanism of tracheoesophageal shunt phonation. Arch Otolaryngol Head Neck Surg 120, 648\u2013652 (1994).","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"46223_CR7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0385-8146(12)80010-1","volume":"21","author":"M Mohri","year":"1994","unstructured":"Mohri, M., Yoshifuji, M., Kinishi, M. & Amatsu, M. Neoglottic activity in tracheoesophageal phonation. Auris Nasus Larynx 21, 53\u201358 (1994).","journal-title":"Auris Nasus Larynx"},{"key":"46223_CR8","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1177\/000348948909801208","volume":"98","author":"RH Pindzola","year":"1989","unstructured":"Pindzola, R. H. & Cain, B. H. Duration and frequency characteristics of tracheoesophageal speech. Ann Otol Rhinol Laryngol 98, 960\u2013964 (1989).","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"46223_CR9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1177\/019459988509300313","volume":"93","author":"SJ Wetmore","year":"1985","unstructured":"Wetmore, S. J. et al. Location of the vibratory segment in tracheoesophageal speakers. Otolaryngol Head Neck Surg 93, 355\u2013361 (1985).","journal-title":"Otolaryngol Head Neck Surg"},{"key":"46223_CR10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0892-1997(05)80341-8","volume":"7","author":"GS Berke","year":"1993","unstructured":"Berke, G. S. & Gerratt, B. R. Laryngeal biomechanics: an overview of mucosal wave mechanics. J Voice 7, 123\u2013128 (1993).","journal-title":"J Voice"},{"key":"46223_CR11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/lary.22459","volume":"122","author":"OA Albirmawy","year":"2012","unstructured":"Albirmawy, O. A., Elsheikh, M. N., Silver, C. E., Rinaldo, A. & Ferlito, A. Contemporary review: Impact of primary neopharyngoplasty on acoustic characteristics of alaryngeal tracheoesophageal voice. Laryngoscope 122, 299\u2013306 (2012).","journal-title":"Laryngoscope"},{"key":"46223_CR12","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.jvoice.2004.07.011","volume":"19","author":"CJ van As-Brooks","year":"2005","unstructured":"van As-Brooks, C. J., Hilgers, F. J., Koopmans-van Beinum, F. J. & Pols, L. C. Anatomical and functional correlates of voice quality in tracheoesophageal speech. J Voice 19, 360\u2013372 (2005).","journal-title":"J Voice"},{"key":"46223_CR13","first-page":"115","volume":"42","author":"TL Eadie","year":"2005","unstructured":"Eadie, T. L. & Doyle, P. C. Quality of life in male tracheoesophageal (TE) speakers. J Rehabil Res Dev 42, 115\u2013124 (2005).","journal-title":"J Rehabil Res Dev"},{"key":"46223_CR14","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1080\/00016480310015290","volume":"124","author":"CJ Van As","year":"2004","unstructured":"Van As, C. J., Op de Coul, B. M., Eysholdt, U. & Hilgers, F. J. Value of digital high-speed endoscopy in addition to videofluoroscopic imaging of the neoglottis in tracheoesophageal speech. Acta Otolaryngol 124, 82\u201389 (2004).","journal-title":"Acta Otolaryngol"},{"key":"46223_CR15","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1097\/00005537-199812000-00003","volume":"108","author":"JP Dworkin","year":"1998","unstructured":"Dworkin, J. P. et al. Videostroboscopy of the pharyngoesophageal segment in total laryngectomees. Laryngoscope 108, 1773\u20131781 (1998).","journal-title":"Laryngoscope"},{"key":"46223_CR16","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1002\/hed.22921","volume":"35","author":"TK Takeshita","year":"2013","unstructured":"Takeshita, T. K. et al. Relation between the dimensions and intraluminal pressure of the pharyngoesophageal segment and tracheoesophageal voice and speech proficiency. Head Neck 35, 500\u2013504 (2013).","journal-title":"Head Neck"},{"key":"46223_CR17","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1001\/archotol.127.2.161","volume":"127","author":"CJ van As","year":"2001","unstructured":"van As, C. J., Op de Coul, B. M., van den Hoogen, F. J., Koopmans-van Beinum, F. J. & Hilgers, F. J. Quantitative videofluoroscopy: a new evaluation tool for tracheoesophageal voice production. Arch Otolaryngol Head Neck Surg 127, 161\u2013169 (2001).","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"46223_CR18","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1177\/0003489414538766","volume":"123","author":"TK Takeshita-Monaretti","year":"2014","unstructured":"Takeshita-Monaretti, T. K., Dantas, R. O., Ricz, H. & Aguiar-Ricz, L. N. Correlation of maximum phonation time and vocal intensity with intraluminal esophageal and pharyngoesophageal pressure in total laryngectomees. Ann Otol Rhinol Laryngol 123, 811\u2013816 (2014).","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"46223_CR19","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1055\/s-0043-110670","volume":"49","author":"PI Wu","year":"2017","unstructured":"Wu, P. I. et al. Clinical utility of a functional lumen imaging probe in management of dysphagia following head and neck cancer therapies. Endoscopy 49, 848\u2013854 (2017).","journal-title":"Endoscopy"},{"key":"46223_CR20","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1177\/0003489416681321","volume":"126","author":"B Arenaz Bua","year":"2017","unstructured":"Arenaz Bua, B., Olsson, R., Westin, U. & Rydell, R. The Pharyngoesophageal Segment After Total Laryngectomy. Ann Otol Rhinol Laryngol 126, 138\u2013145 (2017).","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"46223_CR21","doi-asserted-by":"crossref","unstructured":"Most, T., Tobin, Y. & Mimran, R. C. Acoustic and perceptual characteristics of esophageal and tracheoesophageal speech production. J Commun Disord 33, 165\u2013180; quiz 180\u2013161 (2000).","DOI":"10.1016\/S0021-9924(99)00030-1"},{"key":"46223_CR22","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1080\/14015430701855788","volume":"33","author":"E Lundstrom","year":"2008","unstructured":"Lundstrom, E., Hammarberg, B., Munck-Wikland, E. & Edsborg, N. The pharyngoesophageal segment in laryngectomees\u2013videoradiographic, acoustic, and voice quality perceptual data. Logoped Phoniatr Vocol 33, 115\u2013125 (2008).","journal-title":"Logoped Phoniatr Vocol"},{"key":"46223_CR23","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.jvoice.2005.11.001","volume":"21","author":"L Aguiar-Ricz","year":"2007","unstructured":"Aguiar-Ricz, L. et al. Behavior of the cricopharyngeal segment during esophageal phonation in laryngectomized patients. J Voice 21, 248\u2013256 (2007).","journal-title":"J Voice"},{"key":"46223_CR24","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1017\/S0022215109005398","volume":"123","author":"PN Carding","year":"2009","unstructured":"Carding, P. N., Wilson, J. A., MacKenzie, K. & Deary, I. J. Measuring voice outcomes: state of the science review. J Laryngol Otol 123, 823\u2013829 (2009).","journal-title":"J Laryngol Otol"},{"key":"46223_CR25","unstructured":"PentaxMedical. Computerized Speech Lab, https:\/\/www.pentaxmedical.com\/pentax\/en\/99\/1\/Computerized-Speech-Lab-CSL (2018)."},{"key":"46223_CR26","unstructured":"Boersma, P. & Weenink, D. Praat: doing phonetics by computer, http:\/\/www.fon.hum.uva.nl\/praat\/ (2018)."},{"key":"46223_CR27","unstructured":"Titze, I. R. Workshop on Acoustic Voice Analysis: Summary Statement. (National Center for Voice and Speech, 1995)."},{"key":"46223_CR28","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.1121\/1.3397477","volume":"127","author":"A Sprecher","year":"2010","unstructured":"Sprecher, A., Olszewski, A., Jiang, J. J. & Zhang, Y. Updating signal typing in voice: addition of type 4 signals. J Acoust Soc Am 127, 3710\u20133716 (2010).","journal-title":"J Acoust Soc Am"},{"key":"46223_CR29","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.jvoice.2005.04.008","volume":"20","author":"CJ van As-Brooks","year":"2006","unstructured":"van As-Brooks, C. J., Koopmans-van Beinum, F. J., Pols, L. C. & Hilgers, F. J. Acoustic signal typing for evaluation of voice quality in tracheoesophageal speech. J Voice 20, 355\u2013368 (2006).","journal-title":"J Voice"},{"key":"46223_CR30","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1044\/jshr.3902.311","volume":"39","author":"J Hillenbrand","year":"1996","unstructured":"Hillenbrand, J. & Houde, R. A. Acoustic correlates of breathy vocal quality: dysphonic voices and continuous speech. J Speech Hear Res 39, 311\u2013321 (1996).","journal-title":"J Speech Hear Res"},{"key":"46223_CR31","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1044\/jshr.3704.769","volume":"37","author":"J Hillenbrand","year":"1994","unstructured":"Hillenbrand, J., Cleveland, R. A. & Erickson, R. L. Acoustic correlates of breathy vocal quality. J Speech Hear Res 37, 769\u2013778 (1994).","journal-title":"J Speech Hear Res"},{"key":"46223_CR32","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1177\/000348940311200406","volume":"112","author":"YD Heman-Ackah","year":"2003","unstructured":"Heman-Ackah, Y. D. et al. Cepstral peak prominence: a more reliable measure of dysphonia. The Annals of otology, rhinology, and laryngology 112, 324\u2013333 (2003).","journal-title":"The Annals of otology, rhinology, and laryngology"},{"key":"46223_CR33","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.jvoice.2014.05.005","volume":"28","author":"YD Heman-Ackah","year":"2014","unstructured":"Heman-Ackah, Y. D. et al. Quantifying the cepstral peak prominence, a measure of dysphonia. J Voice 28, 783\u2013788 (2014).","journal-title":"J Voice"},{"key":"46223_CR34","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1002\/lary.20620","volume":"119","author":"Y Maryn","year":"2009","unstructured":"Maryn, Y., Dick, C., Vandenbruaene, C., Vauterin, T. & Jacobs, T. Spectral, cepstral, and multivariate exploration of tracheoesophageal voice quality in continuous speech and sustained vowels. Laryngoscope 119, 2384\u20132394 (2009).","journal-title":"Laryngoscope"},{"key":"46223_CR35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000371656","volume":"67","author":"CR Watts","year":"2015","unstructured":"Watts, C. R. The Effect of CAPE-V Sentences on Cepstral\/Spectral Acoustic Measures in Dysphonic Speakers. Folia Phoniatr Logop 67, 15\u201320 (2015).","journal-title":"Folia Phoniatr Logop"},{"issue":"670","key":"46223_CR36","first-page":"e615","volume":"26","author":"SN Awan","year":"2012","unstructured":"Awan, S. N., Giovinco, A. & Owens, J. Effects of vocal intensity and vowel type on cepstral analysis of voice. J Voice 26(670), e615\u2013620 (2012).","journal-title":"J Voice"},{"key":"46223_CR37","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s40857-018-0139-6","volume":"46","author":"C Madill","year":"2018","unstructured":"Madill, C., Nguyen, D. D., Eastwood, C., Heard, R. & Warhurst, S. Comparison of cepstral peak prominence measures using the ADSV, SpeechTool and VoiceSauce acoustic analysis programs. Acoustics Australia 46, 215\u2013226 (2018).","journal-title":"Acoustics Australia"},{"key":"46223_CR38","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1308\/147870811X13137608454975","volume":"93","author":"N Deore","year":"2011","unstructured":"Deore, N. et al. Acoustic analysis of tracheo-oesophageal voice in male total laryngectomy patients. Ann. R. Coll. Surg. Engl. 93, 523\u2013527 (2011).","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"46223_CR39","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.jvoice.2007.08.005","volume":"23","author":"G Torrejano","year":"2009","unstructured":"Torrejano, G. & Guimaraes, I. Voice quality after supracricoid laryngectomy and total laryngectomy with insertion of voice prosthesis. J Voice 23, 240\u2013246 (2009).","journal-title":"J Voice"},{"key":"46223_CR40","first-page":"240","volume":"25","author":"A Schindler","year":"2005","unstructured":"Schindler, A. et al. Intensity and fundamental frequency control in tracheoesophageal voice. Acta Otorhinolaryngol. Ital. 25, 240\u2013244 (2005).","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"46223_CR41","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1080\/14015430410033218","volume":"29","author":"D Globlek","year":"2004","unstructured":"Globlek, D., Stajner-Katusic, S., Musura, M., Horga, D. & Liker, M. Comparison of alaryngeal voice and speech. Logoped Phoniatr Vocol 29, 87\u201391 (2004).","journal-title":"Logoped Phoniatr Vocol"},{"key":"46223_CR42","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.cgh.2016.10.022","volume":"15","author":"I Hirano","year":"2017","unstructured":"Hirano, I., Pandolfino, J. E. & Boeckxstaens, G. E. Functional Lumen Imaging Probe for the Management of Esophageal Disorders: Expert Review From the Clinical Practice Updates Committee of the AGA Institute. Clin Gastroenterol Hepatol 15, 325\u2013334 (2017).","journal-title":"Clin Gastroenterol Hepatol"},{"key":"46223_CR43","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1007\/s00464-010-1073-3","volume":"24","author":"S Perretta","year":"2010","unstructured":"Perretta, S., Dallemagne, B., Allemann, P. & Marescaux, J. Multimedia manuscript. Heller myotomy and intraluminal fundoplication: a NOTES technique. Surg Endosc 24, 2903 (2010).","journal-title":"Surg Endosc"},{"issue":"Suppl 1","key":"46223_CR44","first-page":"191","volume":"25","author":"L Praduodenal","year":"2011","unstructured":"Praduodenal, L. Abstracts of the 2011 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES). San Antonio, Texas, USA March 30- April 2, 2011. Surg Endosc 25(Suppl 1), 191\u2013388 (2011).","journal-title":"Surg Endosc"},{"key":"46223_CR45","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1007\/s00330-016-4516-y","volume":"27","author":"M Scharitzer","year":"2017","unstructured":"Scharitzer, M. et al. Comparison of videofluoroscopy and impedance planimetry for the evaluation of oesophageal stenosis: a retrospective study. Eur Radiol 27, 1760\u20131767 (2017).","journal-title":"Eur Radiol"},{"key":"46223_CR46","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1007\/s00464-011-1996-3","volume":"26","author":"LK Nathanson","year":"2012","unstructured":"Nathanson, L. K., Brunott, N. & Cavallucci, D. Adult esophagogastric junction distensibility during general anesthesia assessed with an endoscopic functional luminal imaging probe (EndoFLIP(R). Surg Endosc 26, 1051\u20131055 (2012).","journal-title":"Surg Endosc"},{"key":"46223_CR47","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.gie.2010.01.069","volume":"72","author":"MA Kwiatek","year":"2010","unstructured":"Kwiatek, M. A., Pandolfino, J. E., Hirano, I. & Kahrilas, P. J. Esophagogastric junction distensibility assessed with an endoscopic functional luminal imaging probe (EndoFLIP). Gastrointestinal endoscopy 72, 272\u2013278 (2010).","journal-title":"Gastrointestinal endoscopy"},{"key":"46223_CR48","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1111\/nmo.12610","volume":"27","author":"MM Szczesniak","year":"2015","unstructured":"Szczesniak, M. M. et al. Inter-rater reliability and validity of automated impedance manometry analysis and fluoroscopy in dysphagic patients after head and neck cancer radiotherapy. Neurogastroenterol Motil 27, 1183\u20131189 (2015).","journal-title":"Neurogastroenterol Motil"},{"key":"46223_CR49","doi-asserted-by":"publisher","first-page":"G377","DOI":"10.1152\/ajpgi.00311.2006","volume":"292","author":"BP McMahon","year":"2007","unstructured":"McMahon, B. P. et al. The functional lumen imaging probe (FLIP) for evaluation of the esophagogastric junction. American journal of physiology. Gastrointestinal and liver physiology 292, G377\u2013384 (2007).","journal-title":"American journal of physiology. Gastrointestinal and liver physiology"},{"key":"46223_CR50","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1177\/0194599816639249","volume":"155","author":"T Zhang","year":"2016","unstructured":"Zhang, T. et al. Biomechanics of Pharyngeal Deglutitive Function following Total Laryngectomy. Otolaryngol Head Neck Surg 155, 295\u2013302 (2016).","journal-title":"Otolaryngol Head Neck Surg"},{"key":"46223_CR51","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/S0022-3999(02)00469-5","volume":"54","author":"IJ Deary","year":"2003","unstructured":"Deary, I. J., Wilson, J. A., Carding, P. N. & MacKenzie, K. VoiSS: a patient-derived Voice Symptom Scale. J Psychosom Res 54, 483\u2013489 (2003).","journal-title":"J Psychosom Res"},{"key":"46223_CR52","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jvoice.2008.05.006","volume":"24","author":"RC Branski","year":"2010","unstructured":"Branski, R. C. et al. Measuring quality of life in dysphonic patients: a systematic review of content development in patient-reported outcomes measures. J Voice 24, 193\u2013198 (2010).","journal-title":"J Voice"},{"key":"46223_CR53","doi-asserted-by":"publisher","first-page":"506 e509","DOI":"10.1016\/j.jvoice.2015.05.022","volume":"30","author":"M Behlau","year":"2016","unstructured":"Behlau, M. et al. Efficiency and Cutoff Values of Self-Assessment Instruments on the Impact of a Voice Problem. J Voice 30, 506 e509\u2013506 e518 (2016).","journal-title":"J Voice"},{"key":"46223_CR54","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.0307-7772.2004.00775.x","volume":"29","author":"JA Wilson","year":"2004","unstructured":"Wilson, J. A. et al. The Voice Symptom Scale (VoiSS) and the Vocal Handicap Index (VHI): a comparison of structure and content. Clin Otolaryngol Allied Sci 29, 169\u2013174 (2004).","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"46223_CR55","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1044\/1058-0360(2010\/09-0091)","volume":"19","author":"JG Svec","year":"2010","unstructured":"Svec, J. G. & Granqvist, S. Guidelines for selecting microphones for human voice production research. Am J Speech Lang Pathol 19, 356\u2013368 (2010).","journal-title":"Am J Speech Lang Pathol"},{"key":"46223_CR56","unstructured":"Boersma, P. & Weenink, D. Praat: Doing phonetics by computer Version 5.1.02, http:\/\/www.praat.org (2009)."},{"key":"46223_CR57","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.jvoice.2014.11.005","volume":"29","author":"MD Skowronski","year":"2015","unstructured":"Skowronski, M. D., Shrivastav, R. & Hunter, E. J. Cepstral Peak Sensitivity: A Theoretic Analysis and Comparison of Several Implementations. J Voice 29, 670\u2013681 (2015).","journal-title":"J Voice"},{"key":"46223_CR58","unstructured":"PentaxMedical. Analysis of Dysphonia in Speech and Voice - ADSV, https:\/\/www.pentaxmedical.com\/pentax\/en\/99\/1\/Analysis-of-Dysphonia-in-Speech-and-Voice-ADSV (2018)."},{"key":"46223_CR59","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1121\/1.3224706","volume":"126","author":"Y Maryn","year":"2009","unstructured":"Maryn, Y., Roy, N., De Bodt, M., Van Cauwenberge, P. & Corthals, P. Acoustic measurement of overall voice quality: a meta-analysis. J Acoust Soc Am 126, 2619\u20132634 (2009).","journal-title":"J Acoust Soc Am"},{"key":"46223_CR60","unstructured":"GraphPad Software, https:\/\/www.graphpad.com\/scientific-software\/prism\/ (2018)."},{"key":"46223_CR61","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/028418519403500119","volume":"35","author":"R Olsson","year":"1994","unstructured":"Olsson, R., Nilsson, H. & Ekberg, O. Simultaneous videoradiography and computerized pharyngeal manometry\u2013videomanometry. Acta Radiol 35, 30\u201334 (1994).","journal-title":"Acta Radiol"},{"key":"46223_CR62","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1044\/jshr.3003.387","volume":"30","author":"JB Moon","year":"1987","unstructured":"Moon, J. B. & Weinberg, B. Aerodynamic and myoelastic contributions to tracheoesophageal voice production. J Speech Hear Res 30, 387\u2013395 (1987).","journal-title":"J Speech Hear Res"},{"key":"46223_CR63","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1121\/1.414354","volume":"98","author":"JC Lucero","year":"1995","unstructured":"Lucero, J. C. The minimum lung pressure to sustain vocal fold oscillation. The Journal of the Acoustical Society of America 98, 779\u2013784 (1995).","journal-title":"The Journal of the Acoustical Society of America"},{"key":"46223_CR64","unstructured":"Baken, R. J. & Orlikoff, R. F. Clinical measurement of speech and voice. Second edition edn, (Singular Publishing Group, 2000)."},{"key":"46223_CR65","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.anl.2007.08.003","volume":"35","author":"W Grolman","year":"2008","unstructured":"Grolman, W. et al. Vocal efficiency in tracheoesophageal phonation. Auris Nasus Larynx 35, 83\u201388 (2008).","journal-title":"Auris Nasus Larynx"},{"key":"46223_CR66","unstructured":"Ishizaka, K. & Matsudaira, M. Fluid Mechanical Considerations of Vocal Cord Vibration. (SCRL Monograph Series, 1972)."},{"key":"46223_CR67","doi-asserted-by":"publisher","first-page":"E122","DOI":"10.1002\/hed.21961","volume":"35","author":"DA Chaukar","year":"2013","unstructured":"Chaukar, D. A. et al. Ultrasound-guided botulinum toxin injection: A simple in-office technique to improve tracheoesophageal speech in postlaryngectomy patients. Head Neck 35, E122\u2013125 (2013).","journal-title":"Head Neck"},{"key":"46223_CR68","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1109\/TBME.2004.827938","volume":"51","author":"J Lohscheller","year":"2004","unstructured":"Lohscheller, J. et al. Quantitative investigation of the vibration pattern of the substitute voice generator. IEEE Trans Biomed Eng 51, 1394\u20131400 (2004).","journal-title":"IEEE Trans Biomed Eng"},{"key":"46223_CR69","doi-asserted-by":"publisher","first-page":"e5707","DOI":"10.1097\/MD.0000000000005707","volume":"96","author":"L Jiang","year":"2017","unstructured":"Jiang, L. et al. Comprehensive swallowing exercises to treat complicated dysphagia caused by esophageal replacement with colon: A case report. Medicine (Baltimore) 96, e5707 (2017).","journal-title":"Medicine (Baltimore)"},{"key":"46223_CR70","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1017\/S0022215109991320","volume":"124","author":"RL Harris","year":"2010","unstructured":"Harris, R. L., Grundy, A. & Odutoye, T. Radiologically guided balloon dilatation of neopharyngeal strictures following total laryngectomy and pharyngolaryngectomy: 21 years\u2019 experience. J Laryngol Otol 124, 175\u2013179 (2010).","journal-title":"J Laryngol Otol"},{"key":"46223_CR71","first-page":"S","volume":"142","author":"S Paramsothy","year":"2012","unstructured":"Paramsothy, S., Maclean, J., Szczesniak, M. M. & Cook, I. J. Sa1175 Cricopharyngeal Dilatation for Post Laryngectomy Dysphagia - a Pilot Study of Efficacy and Safety. Gastroenterology 142, S\u2013235 (2012).","journal-title":"Gastroenterology"},{"key":"46223_CR72","unstructured":"Garrett, R. Cepstral- and spectral-based acoustic measures of normal voices Master of Science thesis, University of Wisconsin-Milwaukee (2013)."},{"key":"46223_CR73","unstructured":"Phadke, K. V. Selected topics in laryngeal, perceptual and acoustic assessments of human voice: Videokymographic evaluations of vocal folds and investigations of teachers\u2019 voices. PhD thesis, Palack\u00fd University Olomouc, (2018)."},{"key":"46223_CR74","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1044\/jshr.2401.85","volume":"24","author":"CB Angermeier","year":"1981","unstructured":"Angermeier, C. B. & Weinberg, B. Some aspects of fundamental frequency control by esophageal speakers. J Speech Hear Res 24, 85\u201391 (1981).","journal-title":"J Speech Hear Res"},{"key":"46223_CR75","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jvoice.2005.01.001","volume":"20","author":"JJ Jiang","year":"2006","unstructured":"Jiang, J. J., Zhang, Y. & McGilligan, C. Chaos in voice, from modeling to measurement. J Voice 20, 2\u201317 (2006).","journal-title":"J Voice"},{"key":"46223_CR76","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/hed.21692","volume":"34","author":"SM Robertson","year":"2012","unstructured":"Robertson, S. M., Yeo, J. C., Dunnet, C., Young, D. & Mackenzie, K. Voice, swallowing, and quality of life after total laryngectomy: results of the west of Scotland laryngectomy audit. Head Neck 34, 59\u201365 (2012).","journal-title":"Head Neck"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46223-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46223-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46223-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T11:15:41Z","timestamp":1671275741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46223-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,5]]},"references-count":76,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["46223"],"URL":"https:\/\/doi.org\/10.1038\/s41598-019-46223-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,5]]},"assertion":[{"value":"15 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"9722"}}