{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:26:59Z","timestamp":1790137619501,"version":"4.0.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Manatu Hauora | Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["12\/372"],"award-info":[{"award-number":["12\/372"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Manatu Hauora | Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["12\/372"],"award-info":[{"award-number":["12\/372"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Manatu Hauora | Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["12\/372"],"award-info":[{"award-number":["12\/372"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Manatu Hauora | Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["12\/372"],"award-info":[{"award-number":["12\/372"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Manatu Hauora | Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["12\/372"],"award-info":[{"award-number":["12\/372"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001515","name":"Cure Kids","doi-asserted-by":"publisher","award":["5357"],"award-info":[{"award-number":["5357"]}],"id":[{"id":"10.13039\/501100001515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001515","name":"Cure Kids","doi-asserted-by":"publisher","award":["5357"],"award-info":[{"award-number":["5357"]}],"id":[{"id":"10.13039\/501100001515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001515","name":"Cure Kids","doi-asserted-by":"publisher","award":["5357"],"award-info":[{"award-number":["5357"]}],"id":[{"id":"10.13039\/501100001515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008315","name":"Nurture Foundation for Reproductive Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008315","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006346","name":"University of Auckland | Faculty of Medical and Health Sciences, University of Auckland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006346","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated fetal movement quality and pattern and association with late stillbirth in this multicentre case-control study. Cases (n\u2009=\u2009164) had experienced a non-anomalous singleton late stillbirth. Controls (n\u2009=\u2009569) were at a similar gestation with non-anomalous singleton ongoing pregnancy. Data on perceived fetal movements were collected via interviewer-administered questionnaire. We compared categorical fetal movement variables between cases and controls using multivariable logistic regression, adjusting for possible confounders. In multivariable analysis, maternal perception of the following fetal movement variables was associated with decreased risk of late stillbirth; multiple instances of \u2018more vigorous than usual\u2019 fetal movement (aOR 0.52, 95% CI 0.32\u20130.82), daily perception of fetal hiccups (aOR 0.28, 95%CI 0.15\u20130.52), and perception of increased length of fetal movement clusters or \u2018busy times\u2019 (aOR 0.23, 95%CI 0.11\u20130.47). Conversely, the following maternally perceived fetal movement variables were associated with increased risk of late stillbirth; decreased frequency of fetal movements (aOR 2.29, 95%CI 1.31\u20134.0), and perception of \u2018quiet or light\u2019 fetal movement in the evening (aOR 3.82, 95%CI 1.57\u20139.31). In conclusion, women with stillbirth were more likely than controls to have experienced alterations in fetal movement, including decreased strength, frequency and in particular a fetus that was \u2018quiet\u2019 in the evening.<\/jats:p>","DOI":"10.1038\/s41598-019-46323-4","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T10:32:20Z","timestamp":1562581940000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Association between maternally perceived quality and pattern of fetal movements and late stillbirth"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-7459","authenticated-orcid":false,"given":"Billie F.","family":"Bradford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin S.","family":"Cronin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9915-7873","authenticated-orcid":false,"given":"Lesley M. E.","family":"McCowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J. D.","family":"McKinlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin A.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M. D.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"46323_CR1","doi-asserted-by":"crossref","unstructured":"Froen, J. F. A kick from within- fetal movement counting and the cancelled progress in antenatal care. J. Perinat. Med. 13\u201324 (2004).","DOI":"10.1515\/JPM.2004.003"},{"key":"46323_CR2","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1080\/01443610500278303","volume":"25","author":"AEP Heazell","year":"2005","unstructured":"Heazell, A. E. P., Sumathi, G. M. & Bhatti, N. R. What investigation is appropriate following maternal perception of reduced fetal movements? J. Obstet. Gynaecol. 25, 648\u2013650 (2005).","journal-title":"J. Obstet. Gynaecol."},{"issue":"4","key":"46323_CR3","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/ajo.12762","volume":"58","author":"Lisa M. Daly","year":"2018","unstructured":"Daly, L. M. et al. Care of pregnant women with decreased fetal movements: Update of a clinical practice guideline for Australia and New Zealand. Aust. N. Z. J. Obstet. Gynaecol, https:\/\/doi.org\/10.1111\/ajo.12762 (2018).","journal-title":"Australian and New Zealand Journal of Obstetrics and Gynaecology"},{"key":"46323_CR4","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1080\/01443610050009494","volume":"20","author":"DK James","year":"2000","unstructured":"James, D. K. et al. Reduced fetal movements and maternal medication - new pregnancy risk factors for neurodevelopmental disability in childhood. J. Obstet. Gynaecol. J. Inst. Obstet. Gynaecol. 20, 226\u2013234 (2000).","journal-title":"J. Obstet. Gynaecol. J. Inst. Obstet. Gynaecol."},{"key":"46323_CR5","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.3109\/14767058.2011.644361","volume":"25","author":"M Dodds","year":"2012","unstructured":"Dodds, M., Windrim, R. & Kingdom, J. Complex umbilical cord entanglement. J. Matern. Fetal Neonatal Med. 25, 1827\u20131829 (2012).","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"46323_CR6","doi-asserted-by":"publisher","first-page":"e34851","DOI":"10.1371\/journal.pone.0034851","volume":"7","author":"LK Warrander","year":"2012","unstructured":"Warrander, L. K. et al. Maternal perception of reduced fetal movements is associated with altered placental structure and function. PLoS ONE 7, e34851 (2012).","journal-title":"PLoS ONE"},{"key":"46323_CR7","unstructured":"Term, singleton, normally formed, antepartum stillbirth. (The Infant Mortality and Morbidity Studies, Department of Health Sciences, University of Leicester, 2015)."},{"key":"46323_CR8","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1080\/00016340701207724","volume":"86","author":"E Saastad","year":"2007","unstructured":"Saastad, E., Vangen, S. & Frederik Fr\u00f8en, J. Suboptimal care in stillbirths \u2013 a retrospective audit study. Acta Obstet. Gynecol. Scand. 86, 444\u2013450 (2007).","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"46323_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-9-32","volume":"9","author":"J Tveit","year":"2009","unstructured":"Tveit, J. et al. Reduction of late stillbirth with the introduction of fetal movement information and guidelines \u2013 a clinical quality improvement. BMC Pregnancy Childbirth 9, 32 (2009).","journal-title":"BMC Pregnancy Childbirth"},{"issue":"10158","key":"46323_CR10","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1016\/S0140-6736(18)31543-5","volume":"392","author":"Jane E Norman","year":"2018","unstructured":"Norman, J. E. et al. Awareness of fetal movements and care package to reduce fetal mortality (AFFIRM): a stepped wedge, cluster-randomised trial. The Lancet, https:\/\/doi.org\/10.1016\/S0140-6736(18)31543-5 (2018).","journal-title":"The Lancet"},{"key":"46323_CR11","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.jmwh.2008.03.001","volume":"53","author":"E Saastad","year":"2008","unstructured":"Saastad, E., Ahlborg, T. & Fr\u00f8en, J. Low maternal awareness of fetal movement is associated with small for gestational age infants. J. Midwifery Womens Health 53, 345\u2013352 (2008).","journal-title":"J. Midwifery Womens Health"},{"key":"46323_CR12","doi-asserted-by":"publisher","first-page":"e0179396","DOI":"10.1371\/journal.pone.0179396","volume":"12","author":"LME McCowan","year":"2017","unstructured":"McCowan, L. M. E. et al. Going to sleep in the supine position is a modifiable risk factor for late pregnancy stillbirth; Findings from the New Zealand multicentre stillbirth case-control study. PLOS ONE 12, e0179396 (2017).","journal-title":"PLOS ONE"},{"key":"46323_CR13","doi-asserted-by":"publisher","first-page":"e020031","DOI":"10.1136\/bmjopen-2017-020031","volume":"8","author":"AEP Heazell","year":"2018","unstructured":"Heazell, A. E. P. et al. Alterations in maternally perceived fetal movement and their association with late stillbirth: findings from the Midland and North of England stillbirth case\u2013control study. BMJ Open 8, e020031 (2018).","journal-title":"BMJ Open"},{"key":"46323_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1523-536X.2011.00490.x","volume":"38","author":"T Stacey","year":"2011","unstructured":"Stacey, T. et al. Maternal perception of fetal activity and late stillbirth risk; findings from the Auckland stillbirth study. Birth 38, 1\u20136 (2011).","journal-title":"Birth"},{"key":"46323_CR15","first-page":"53","volume":"6","author":"S Efkarpidis","year":"2004","unstructured":"Efkarpidis, S., Alexopoulos, E., Kean, L., Liu, D. & Fay, T. Case-control study of factors associated with intrauterine fetal deaths. Medscape Gen. Med. 6, 53 (2004).","journal-title":"Medscape Gen. Med."},{"key":"46323_CR16","first-page":"845","volume":"41","author":"E Sadovsky","year":"1973","unstructured":"Sadovsky, E. & Yaffe, H. Daily fetal movement recording and fetal prognosis. Obstet. Gynecol. 41, 845\u2013850 (1973).","journal-title":"Obstet. Gynecol."},{"key":"46323_CR17","doi-asserted-by":"crossref","unstructured":"Mangesi, L., Hofmeyr, G. J., Smith, V. & Smyth, R. M. Fetal movement counting for assessment of fetal wellbeing. in Cochrane Database of Systematic Reviews (ed. The Cochrane Collaboration) (John Wiley & Sons, Ltd, 2015).","DOI":"10.1002\/14651858.CD004909.pub3"},{"key":"46323_CR18","doi-asserted-by":"crossref","unstructured":"Smyth, R. M. D. et al. Women\u2019s and clinicians perspectives of presentation with reduced fetal movements: a qualitative study. BMC Pregnancy Childbirth 16 (2016).","DOI":"10.1186\/s12884-016-1074-x"},{"key":"46323_CR19","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/0002-9378(89)90164-6","volume":"160","author":"T Moore","year":"1989","unstructured":"Moore, T. & Piacquadio, K. A prospective evaluation of fetal movement screening to reduce the incidence of antepartum fetal death. Am. J. Obstet. Gynecol. 160, 1075\u20131080 (1989).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"46323_CR20","doi-asserted-by":"publisher","first-page":"733","DOI":"10.12968\/bjom.1999.7.12.8208","volume":"7","author":"M Fisher","year":"1999","unstructured":"Fisher, M. Reduced fetal movements: a research based project. Br. J. Midwifery 7, 733\u2013737 (1999).","journal-title":"Br. J. Midwifery"},{"key":"46323_CR21","doi-asserted-by":"publisher","first-page":"539","DOI":"10.3109\/00016348409156716","volume":"63","author":"C Ehrstr\u00f6m","year":"1984","unstructured":"Ehrstr\u00f6m, C. Orcadian Rhythm of Fetal Movements. Acta Obstet. Gynecol. Scand. 63, 539\u2013541 (1984).","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"46323_CR22","doi-asserted-by":"publisher","first-page":"e287","DOI":"10.1016\/j.wombi.2017.12.007","volume":"31","author":"B Bradford","year":"2018","unstructured":"Bradford, B. & Maude, R. Maternal perception of fetal movements in the third trimester: A qualitative description. Women Birth 31, e287\u2013e293 (2018).","journal-title":"Women Birth"},{"key":"46323_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-32","volume":"13","author":"CH Raynes-Greenow","year":"2013","unstructured":"Raynes-Greenow, C. H., Gordon, A., Li, Q. & Hyett, J. A. A cross-sectional study of maternal perception of fetal movements and antenatal advice in a general pregnant population, using a qualitative framework. BMC Pregnancy Childbirth 13, 32 (2013).","journal-title":"BMC Pregnancy Childbirth"},{"key":"46323_CR24","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/j.1471-0528.1979.tb11273.x","volume":"86","author":"DS Minors","year":"1979","unstructured":"Minors, D. S. & Waterhouse, J. M. The effect of maternal, posture, meals and time of day on fetal movements. Br. J. Obstet. Gynaecol. 86, 717\u2013723 (1979).","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"46323_CR25","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/S0002-9378(16)32375-4","volume":"142","author":"J Patrick","year":"1982","unstructured":"Patrick, J., Campbell, K., Carmicheal, L., Natale, R. & Richardson, B. Patterns of gross fetal body movements over 24-hour observation intervals during the last 10 weeks of pregnancy. Am. J. Obstet. Gynecol. 142, 363\u2013371 (1982).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"46323_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1740-3391-3-5","volume":"3","author":"P Kintraia","year":"2005","unstructured":"Kintraia, P., Zarnadze, M. & Kintraia, N. & Kashakashvili. Development of daily rhythmicity in heart rate and locomotor activity in the human fetus. J. Circadian Rhythms 3, 1\u201312 (2005).","journal-title":"J. Circadian Rhythms"},{"key":"46323_CR27","doi-asserted-by":"crossref","unstructured":"Visser, G. H., Goodman, J. D. S., Levine, D. H. & Dawes, G. S. Diurnal and other cyclic variations in fetal heart rate near term. Am. J. Obstet. Gynecol. 142 (1982).","DOI":"10.1016\/0002-9378(82)90757-8"},{"key":"46323_CR28","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.1016\/S0140-6736(17)32661-2","volume":"390","author":"T Burki","year":"2017","unstructured":"Burki, T. Nobel Prize awarded for discoveries in circadian rhythm. The Lancet 390, e25 (2017).","journal-title":"The Lancet"},{"key":"46323_CR29","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ijgo.2005.05.011","volume":"90","author":"R Babazadeh","year":"2005","unstructured":"Babazadeh, R., Abdali, K., Lotfalizadeh, M., Tabatabaie, H. R. & Kaviani, M. Diurnal nonstress test variations in the human fetus at risk. Int. J. Gynecol. Obstet. 90, 189\u2013192 (2005).","journal-title":"Int. J. Gynecol. Obstet."},{"key":"46323_CR30","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3109\/14767058.2011.576721","volume":"25","author":"E Ozkaya","year":"2012","unstructured":"Ozkaya, E., Baser, E., Cinar, M., Korkmaz, V. & Kucukozkan, T. Does diurnal rhythm have an impact on fetal biophysical profile? J. Matern. Fetal Neonatal Med. 25, 335\u2013338 (2012).","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"46323_CR31","doi-asserted-by":"crossref","unstructured":"Pillai, M. & James, D. Behavioural states in normal mature human fetuses. Arch. Dis. Child. 39\u201343 (1990).","DOI":"10.1136\/adc.65.1_Spec_No.39"},{"key":"46323_CR32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0378-3782(82)90033-0","volume":"7","author":"JIP de Vries","year":"1982","unstructured":"de Vries, J. I. P., Visser, G. H. A. & Prechtl, H. F. R. The emergence of fetal behaviour. I. Qualitative aspects. Early Hum. Dev. 7, 301\u2013322 (1982).","journal-title":"Early Hum. Dev."},{"key":"46323_CR33","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/j.1479-828X.2009.01122.x","volume":"50","author":"ZR Hijazi","year":"2010","unstructured":"Hijazi, Z. R., Callan, S. E. & East, C. E. Maternal perception of foetal movement compared with movement detected by real-time ultrasound: An exploratory study. Aust. N. Z. J. Obstet. Gynaecol. 50, 144\u2013147 (2010).","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"46323_CR34","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.3109\/14767058.2015.1077509","volume":"29","author":"R Brown","year":"2016","unstructured":"Brown, R., Higgins, L. E., Johnstone, E. D., Wijekoon, J. H. & Heazell, A. E. P. Maternal perception of fetal movements in late pregnancy is affected by type and duration of fetal movement. J. Matern. Fetal Neonatal Med. 29, 2145\u20132150 (2016).","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"46323_CR35","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0378-3782(03)00031-8","volume":"72","author":"K Sj\u00f6str\u00f6m","year":"2003","unstructured":"Sj\u00f6str\u00f6m, K., Thelin, T., Mar\u0161\u00e1l, K. & Valentin, L. Effects of maternal anxiety on perception of fetal movements in late pregnancy. Early Hum. Dev. 72, 111\u2013122 (2003).","journal-title":"Early Hum. Dev."},{"key":"46323_CR36","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1016\/S0002-9378(97)70131-5","volume":"177","author":"J Collins","year":"1997","unstructured":"Collins, J. Umbilical cord accidents - time of death? Am. J. Obstet. Gynecol. 177, 1566 (1997).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"46323_CR37","doi-asserted-by":"crossref","unstructured":"Pillai, M. & James, D. Hiccups and breathing in human fetus. Arch. Dis. Child. 1072\u20131075 (1990).","DOI":"10.1136\/adc.65.10_Spec_No.1072"},{"key":"46323_CR38","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/bies.201100194","volume":"34","author":"D Howes","year":"2012","unstructured":"Howes, D. Hiccups: A new explanation for the mysterious reflex. BioEssays 34, 451\u2013453 (2012).","journal-title":"BioEssays"},{"key":"46323_CR39","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.mehy.2015.01.040","volume":"84","author":"AG Murchison","year":"2015","unstructured":"Murchison, A. G. Hiccups and amniotic fluid regulation in early pregnancy. Med. Hypotheses 84, 448\u2013450 (2015).","journal-title":"Med. Hypotheses"},{"key":"46323_CR40","first-page":"326","volume":"11","author":"JW Goldkrand","year":"1991","unstructured":"Goldkrand, J. W. & Farkouh, L. Vibroacoustic stimulation and fetal hiccoughs. J. Perinatol. Off. J. Calif. Perinat. Assoc. 11, 326\u2013329 (1991).","journal-title":"J. Perinatol. Off. J. Calif. Perinat. Assoc."},{"key":"46323_CR41","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1093\/ije\/19.2.405","volume":"19","author":"CD Drews","year":"1990","unstructured":"Drews, C. D., Kraus, J. F. & Greenland, S. Recall bias in a case-control study of sudden infant death syndrome. Int. J. Epidemiol. 19, 405\u2013411 (1990).","journal-title":"Int. J. Epidemiol."},{"key":"46323_CR42","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/oxfordjournals.aje.a115125","volume":"129","author":"SG Mackenzie","year":"1989","unstructured":"Mackenzie, S. G. & Lippman, A. An investigation of report bias in a case-control study of pregnancy outcome. Am. J. Epidemiol. 129, 65\u201375 (1989).","journal-title":"Am. J. Epidemiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46323-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46323-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46323-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T11:11:38Z","timestamp":1671275498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46323-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,8]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["46323"],"URL":"https:\/\/doi.org\/10.1038\/s41598-019-46323-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,8]]},"assertion":[{"value":"1 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"9815"}}