{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T14:57:58Z","timestamp":1776351478790,"version":"3.51.2"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Challenges in social communication and interaction are core features of autism spectrum disorder (ASD) for which social skills group training (SSGT) is a commonly used intervention. SSGT has shown modest and heterogeneous effects. One of the major genetic risk factors in ASD is rare copy number variation (CNV). However, limited information exists whether CNV profiles could be used to aid intervention decisions. Here, we analyzed the rare genic CNV carrier status for 207 children, of which 105 received SSGT and 102 standard care as part of a randomized clinical trial for SSGT. We found that being a carrier of rare genic CNV did not have an impact on the SSGT outcome measured by the parent-report Social Responsiveness Scale (SRS). However, when stratifying by pathogenicity and size of the CNVs, we identified that carriers of clinically significant and large genic CNVs (&gt;500\u2009kb) showed inferior SRS outcomes at post-intervention (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.047 and\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.036, respectively) and follow-up (P\u2009=\u20090.008 and\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.072, respectively) when adjusting for\n                    <jats:italic>standard care<\/jats:italic>\n                    effects. Our study provides preliminary evidence that carriers of clinically significant and large genic CNVs might not benefit as much from SSGT as non-carriers. Our results indicate that genetic information might help guide the modifications of interventions in ASD.\n                  <\/jats:p>","DOI":"10.1038\/s41598-019-46396-1","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T06:32:20Z","timestamp":1562567540000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association between Copy Number Variation and Response to Social Skills Training in Autism Spectrum Disorder"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-4697","authenticated-orcid":false,"given":"Kristiina","family":"Tammimies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ielyzaveta","family":"Rabkina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Stamouli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Nicolaou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Berggren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Coco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f6rn","family":"Falkmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Choque-Olsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"B\u00f6lte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"46396_CR1","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1007\/s10803-014-2336-y","volume":"45","author":"S Idring","year":"2015","unstructured":"Idring, S. et al. Changes in prevalence of autism spectrum disorders in 2001-2011: findings from the Stockholm youth cohort. Journal of autism and developmental disorders 45, 1766\u20131773, https:\/\/doi.org\/10.1007\/s10803-014-2336-y (2015).","journal-title":"Journal of autism and developmental disorders"},{"key":"46396_CR2","unstructured":"CDC. (Centers for Disease Control and Prevention (CDC) www.cdc.gov\/ncbddd\/autism\/data.html) (2018)."},{"key":"46396_CR3","unstructured":"APA. Vol. 5th ed. (American Psychiatric Association, 2013)."},{"key":"46396_CR4","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1097\/CHI.0b013e318179964f","volume":"47","author":"E Simonoff","year":"2008","unstructured":"Simonoff, E. et al. Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. 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