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The aim of the study was to assess the association of nesfatin-1 with HPG axis disturbances in OSA. This is a prospective study with consecutive enrolment. It comprises 72 newly diagnosed OSA patients ((AHI: apnoea-hypopnea index) 18 subjects: 5\u2009\u2264\u2009AHI\u2009&lt;\u200915; 24: 15\u2009\u2264\u2009AHI\u2009&lt;\u200930; 30: AHI\u2009\u2265\u200930) and a control group composed of 19 patients (AHI\u2009&lt;\u20095). All patients underwent polysomnography and fasting blood collection for nesfatin-1, testosterone, luteinising hormone (LH), high-sensitivity C-reactive protein (hsCRP), aspartate transaminase (AST), alanine aminotransferase (ALT), creatinine and glucose. Groups had similar levels of LH, nesfatin-1 and testosterone (p\u2009=\u20090.87; p\u2009=\u20090.24; p\u2009=\u20090.08). Nesfatin-1 was not correlated to LH (p\u2009=\u20090.71), testosterone (p\u2009=\u20090.38), AHI (p\u2009=\u20090.34) or the oxygen desaturation index (ODI) (p\u2009=\u20090.69) either in the whole group, or in sub-groups. The study did not reveal any association between the HPG axis and nesfatin-1 in OSA adult males. It is possible that nesfatin-1 is not a mediator of HPG axis disturbances in adult patients with OSA.<\/jats:p>","DOI":"10.1038\/s41598-019-47061-3","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T10:02:59Z","timestamp":1564999379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Does nesfatin-1 influence the hypothalamic\u2013pituitary\u2013gonadal axis in adult males with obstructive sleep apnoea?"],"prefix":"10.1038","volume":"9","author":[{"given":"Halina","family":"Batura-Gabryel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Bromi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Sawicka-Gutaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Cyra\u0144ska-Chyrek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Ku\u017anar-Kami\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Winiarska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Kostrzewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariadna","family":"Zybek-Kocik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Hernik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Wrotkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Bielawska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szczepan","family":"Cofta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Rucha\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"47061_CR1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1586\/17476348.2.3.349","volume":"2","author":"W Lee","year":"2008","unstructured":"Lee, W., Nagubadi, S., Kryger, M. 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