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However, developing methods to recover information encoded in these signals is a significant challenge. We introduce the idea of using spatiotemporal signatures extracted from multi-contact nerve cuff electrode recordings to classify naturally evoked compound action potentials (CAP). 9 Long-Evan rats were implanted with a 56-channel nerve cuff on the sciatic nerve. Afferent activity was selectively evoked in the different fascicles of the sciatic nerve (tibial, peroneal, sural) using mechano-sensory stimuli. Spatiotemporal signatures of recorded CAPs were used to train three different classifiers. Performance was measured based on the classification accuracy, F\n                    <jats:sub>1<\/jats:sub>\n                    -score, and the ability to reconstruct original firing rates of neural pathways. The mean classification accuracies, for a 3-class problem, for the best performing classifier was 0.686\u2009\u00b1\u20090.126 and corresponding mean F\n                    <jats:sub>1<\/jats:sub>\n                    -score was 0.605\u2009\u00b1\u20090.212. The mean Pearson correlation coefficients between the original firing rates and estimated firing rates found for the best classifier was 0.728\u2009\u00b1\u20090.276. The proposed method demonstrates the possibility of classifying individual naturally evoked CAPs in peripheral neural signals recorded from extraneural electrodes, allowing for more precise control signals in neuroprosthetic applications.\n                  <\/jats:p>","DOI":"10.1038\/s41598-019-47450-8","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T06:02:32Z","timestamp":1564552952000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Classification of naturally evoked compound action potentials in peripheral nerve spatiotemporal recordings"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-1008","authenticated-orcid":false,"given":"Ryan G. 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