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This observational cohort study aimed to evaluate the predictive value of procalcitonin (PCT) for DLC in patients with acute cholecystitis (AC). A total of 115 patients were included in the study from January 2017 to April 2018. Multiple logistic regression and receiver-operating characteristic (ROC) were performed to evaluate the predictive value of PCT levels in DLC. Patients with DLC had significantly higher Tokyo Guidelines 2018 (TG18) grade (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) and levels of C-reactive protein (CRP) (<jats:italic>P<\/jats:italic>\u2009=\u20090.007) and PCT (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The cut-off value of PCT for predicting DLC was 1.50\u2009ng\/ml. The sensitivity and specificity were 91.3% (95% CI 78.3\u201397.1) and 76.8% (95% CI 64.8\u201385.8), respectively. The area under ROC curve was 92.7% (95% CI 88.2\u201397.3, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Our results suggested that PCT was a good predictor for DLC in the AC patients, but further research is necessary. Monitoring of PCT trends in AC patients may be useful for preoperative risk assessment.<\/jats:p>","DOI":"10.1038\/s41598-019-47501-0","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T10:21:36Z","timestamp":1564395696000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Role of procalcitonin as a predictor in difficult laparoscopic cholecystectomy for acute cholecystitis case: A retrospective study based on the TG18 criteria"],"prefix":"10.1038","volume":"9","author":[{"given":"Tianchong","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehua","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyun","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,29]]},"reference":[{"key":"47501_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/jhbp.517","volume":"25","author":"G Wakabayashi","year":"2018","unstructured":"Wakabayashi, G. et al. 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