{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:50:37Z","timestamp":1788997837274,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Globally many children are living with grandparents, and it has been suggested that grandparent co-residence may be associated with dental caries in infants and toddlers possibly through passive parenting style, accompanied by children\u2019s cariogenic behaviors such as feeding sugary sweets. However, little is known about this association in schoolchildren, adjusted for socioeconomic status. Therefore, this study investigates the association between grandparent co-residence, socioeconomic status, and dental caries among schoolchildren. All caregivers of first-grade children (age 6\u20137 years) in Adachi City, Tokyo, were administered a questionnaire about children\u2019s grandparent co-residence status and oral health-related behaviors, and responses were linked with dental examination records conducted by school dentists (N\u2009=\u20093,578). Multilevel\u00a0Poisson regression analysis was applied to examine the association between grandparent co-residence, socioeconomic status, and dental caries status for each individual tooth, adjusting for potential covariates. The percentage of dental caries experience was higher among children living with grandparents (48.9%) than among children living without grandparents (44.0%). The risk for caries, however, did not differ according to grandparent co-residence status when tooth type, child\u2019s age and sex, and parental socio-economic status and structure were adjusted (PR, 1.13; 95%CI, 0.90, 1.42). The association between grandparent co-residence and dental caries among early school-aged children in urban Japan was confounded by socioeconomic status.<\/jats:p>","DOI":"10.1038\/s41598-019-47730-3","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T10:02:59Z","timestamp":1564999379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association between grandparent co-residence, socioeconomic status and dental caries among early school-aged children in Japan: A population-based prospective study"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9764-6067","authenticated-orcid":false,"given":"Ayako","family":"Morita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Isumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manami","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1074-3954","authenticated-orcid":false,"given":"Takeo","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"47730_CR1","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1177\/0022034517693566","volume":"96","author":"NJ Kassebaum","year":"2017","unstructured":"Kassebaum, N. J. et al. Global, Regional, and National Prevalence, Incidence, and Disability-Adjusted Life Years for Oral Conditions for 195 Countries, 1990\u20132015: A Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors. J Dent Res 96, 380\u2013387, https:\/\/doi.org\/10.1177\/0022034517693566 (2017).","journal-title":"J Dent Res"},{"key":"47730_CR2","unstructured":"Japanese Ministry of Eduation, Culture, Sports, Science and Technology. (2018)."},{"key":"47730_CR3","first-page":"697","volume":"31","author":"WF Wathen","year":"2000","unstructured":"Wathen, W. F. International implications of \u201coral health in America: a report of the Surgeon General\u201d. Quintessence Int 31, 697 (2000).","journal-title":"Quintessence Int"},{"key":"47730_CR4","doi-asserted-by":"publisher","first-page":"e510","DOI":"10.1542\/peds.2006-3084","volume":"120","author":"SA Fisher-Owens","year":"2007","unstructured":"Fisher-Owens, S. A. et al. Influences on children\u2019s oral health: a conceptual model. Pediatrics 120, e510\u2013520, https:\/\/doi.org\/10.1542\/peds.2006-3084 (2007).","journal-title":"Pediatrics"},{"key":"47730_CR5","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/j.1600-0528.2010.00560.x","volume":"38","author":"DM Shearer","year":"2010","unstructured":"Shearer, D. M. & Thomson, W. M. Intergenerational continuity in oral health: a review. Community Dent Oral Epidemiol 38, 479\u2013486, https:\/\/doi.org\/10.1111\/j.1600-0528.2010.00560.x (2010).","journal-title":"Community Dent Oral Epidemiol"},{"key":"47730_CR6","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.1038\/sj.bdj.2013.655","volume":"215","author":"A Ntouva","year":"2013","unstructured":"Ntouva, A., Tsakos, G. & Watt, R. G. Sugars consumption in a low-income sample of British young people and adults. Br Dent J 215, E2, https:\/\/doi.org\/10.1038\/sj.bdj.2013.655 (2013).","journal-title":"Br Dent J"},{"key":"47730_CR7","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1079\/BJN20051513","volume":"94","author":"CA Vereecken","year":"2005","unstructured":"Vereecken, C. A., De Henauw, S. & Maes, L. Adolescents\u2019 food habits: results of the Health Behaviour in School-aged Children survey. Br J Nutr 94, 423\u2013431 (2005).","journal-title":"Br J Nutr"},{"key":"47730_CR8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1875-595X.2006.tb00089.x","volume":"56","author":"L Maes","year":"2006","unstructured":"Maes, L., Vereecken, C., Vanobbergen, J. & Honkala, S. Tooth brushing and social characteristics of families in 32 countries. Int Dent J 56, 159\u2013167 (2006).","journal-title":"Int Dent J"},{"key":"47730_CR9","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1177\/003335491012500609","volume":"125","author":"BA Dye","year":"2010","unstructured":"Dye, B. A. & Thornton-Evans, G. Trends in Oral Health by Poverty Status as Measured by Healthy People 2010 Objectives. Public Health Reports 125, 817\u2013830 (2010).","journal-title":"Public Health Reports"},{"key":"47730_CR10","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/j.1600-0722.2012.00953.x","volume":"120","author":"AK Mattila","year":"2012","unstructured":"Mattila, A. K., Pohjola, V., Suominen, A. L., Joukamaa, M. & Lahti, S. Difficulties in emotional regulation: association with poorer oral health-related quality of life in the general population. Eur J Oral Sci 120, 224\u2013231, https:\/\/doi.org\/10.1111\/j.1600-0722.2012.00953.x (2012).","journal-title":"Eur J Oral Sci"},{"key":"47730_CR11","doi-asserted-by":"publisher","first-page":"17030","DOI":"10.1038\/nrdp.2017.30","volume":"3","author":"NB Pitts","year":"2017","unstructured":"Pitts, N. B. et al. Dental caries. Nat Rev Dis Primers 3, 17030, https:\/\/doi.org\/10.1038\/nrdp.2017.30 (2017).","journal-title":"Nat Rev Dis Primers"},{"key":"47730_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4103\/0970-4388.155108","volume":"33","author":"A Sujlana","year":"2015","unstructured":"Sujlana, A. & Pannu, P. K. Family related factors associated with caries prevalence in the primary dentition of five-year-old children. J Indian Soc Pedod Prev Dent 33, 83\u201387, https:\/\/doi.org\/10.4103\/0970-4388.155108 (2015).","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"47730_CR13","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jchb.2015.12.002","volume":"67","author":"B Borowska-Struginska","year":"2016","unstructured":"Borowska-Struginska, B. et al. Prenatal and familial factors of caries in first permanent molars in schoolchildren living in urban area of Lodz, Poland. Homo 67, 226\u2013234, https:\/\/doi.org\/10.1016\/j.jchb.2015.12.002 (2016).","journal-title":"Homo"},{"key":"47730_CR14","first-page":"588","volume":"84","author":"KF Kojima","year":"1997","unstructured":"Kojima, K. F. & Niwa, M. M. Relationship between caries prevalence and factors influencing dental health care in infants \u2013 comparison between male and female of 3-year-old children. Shigaku 84, 588\u2013600 (1997).","journal-title":"Shigaku"},{"key":"47730_CR15","doi-asserted-by":"publisher","first-page":"631","DOI":"10.5834\/jdh.38.631","volume":"38","author":"DS Hinode","year":"1988","unstructured":"Hinode, D. S. et al. Analysis of factors influencing the caries prevalence of deciduous teeth in children of three years old. J Dental Health 38, 631\u2013640 (1988).","journal-title":"J Dental Health"},{"key":"47730_CR16","first-page":"15","volume":"63","author":"MT Yamamoto","year":"2013","unstructured":"Yamamoto, M. T., Nakamura, A., Matsuoka, G., Hanioka, N. & Caries, T. prevalence and caries risk factors in children aged 3 to 5 years: cross-sectional study. J Dent Hlth 63, 15\u201320 (2013).","journal-title":"J Dent Hlth"},{"key":"47730_CR17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1600-0528.2007.00380.x","volume":"36","author":"J Aida","year":"2008","unstructured":"Aida, J., Ando, Y., Oosaka, M., Niimi, K. & Morita, M. Contributions of social context to inequality in dental caries: a multilevel analysis of Japanese 3-year-old children. Community Dent Oral Epidemiol 36, 149\u2013156, https:\/\/doi.org\/10.1111\/j.1600-0528.2007.00380.x (2008).","journal-title":"Community Dent Oral Epidemiol"},{"key":"47730_CR18","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s12199-008-0065-6","volume":"14","author":"K Ohsuka","year":"2009","unstructured":"Ohsuka, K. et al. Analysis of risk factors for dental caries in infants: a comparison between urban and rural areas. Environ Health Prev Med 14, 103\u2013110, https:\/\/doi.org\/10.1007\/s12199-008-0065-6 (2009).","journal-title":"Environ Health Prev Med"},{"key":"47730_CR19","doi-asserted-by":"publisher","first-page":"e0185420","DOI":"10.1371\/journal.pone.0185420","volume":"12","author":"SA Chambers","year":"2017","unstructured":"Chambers, S. A., Rowa-Dewar, N., Radley, A. & Dobbie, F. A systematic review of grandparents\u2019 influence on grandchildren\u2019s cancer risk factors. PLoS One 12, e0185420, https:\/\/doi.org\/10.1371\/journal.pone.0185420 (2017).","journal-title":"PLoS One"},{"key":"47730_CR20","doi-asserted-by":"publisher","first-page":"7456","DOI":"10.1016\/j.vaccine.2018.10.017","volume":"36","author":"SP Karthigesu","year":"2018","unstructured":"Karthigesu, S. P., Chisholm, J. S. & Coall, D. A. Do grandparents influence parents\u2019 decision to vaccinate their children? A systematic review. Vaccine 36, 7456\u20137462, https:\/\/doi.org\/10.1016\/j.vaccine.2018.10.017 (2018).","journal-title":"Vaccine"},{"key":"47730_CR21","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s10433-018-0474-3","volume":"15","author":"K Glaser","year":"2018","unstructured":"Glaser, K. et al. Trends in the prevalence of grandparents living with grandchild(ren) in selected European countries and the United States. Eur J Ageing 15, 237\u2013250, https:\/\/doi.org\/10.1007\/s10433-018-0474-3 (2018).","journal-title":"Eur J Ageing"},{"key":"47730_CR22","unstructured":"National Institution for Youth Education. (2018)."},{"key":"47730_CR23","unstructured":"Taylor, A. P. J. et al. The Return of the Multi-Generational Family Household. 5 (PewResearchCenter, 2010)."},{"key":"47730_CR24","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.4054\/DemRes.2014.30.60","volume":"30","author":"NV Pilkauskas","year":"2014","unstructured":"Pilkauskas, N. V. & Martinson, M. L. Three-Generation Family Households in Early Childhood: Comparisons between the United States, the United Kingdom, and Australia. Demogr Res 30, 1639\u20131652, https:\/\/doi.org\/10.4054\/DemRes.2014.30.60 (2014).","journal-title":"Demogr Res"},{"key":"47730_CR25","unstructured":"Liu, E. E. H. Multi-generation households in Australian cities. 10\u201311 (Australian Housing and Urban Research Institute, Melbourne, 2012)."},{"key":"47730_CR26","first-page":"332","volume":"1","author":"KEBB Speirs","year":"2009","unstructured":"Speirs, K. E. B. B., Zoumenou, V., Anderson, E. A. & Finkbeiner, N. Grandmothers\u2019 involvement in preschool-aged children\u2019s consumption of fruits and vegetables. An exploratory study. ICAN: Infant, Child & Adolescent Nutrition. 1, 332\u2013337 (2009).","journal-title":"ICAN: Infant, Child & Adolescent Nutrition."},{"key":"47730_CR27","doi-asserted-by":"publisher","first-page":"112","DOI":"10.5409\/wjcp.v5.i1.112","volume":"5","author":"J Oberoi","year":"2016","unstructured":"Oberoi, J., Kathariya, R., Panda, A., Garg, I. & Raikar, S. Dental knowledge and awareness among grandparents. World J Clin Pediatr 5, 112\u2013117, https:\/\/doi.org\/10.5409\/wjcp.v5.i1.112 (2016).","journal-title":"World J Clin Pediatr"},{"issue":"6","key":"47730_CR28","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.vaccine.2018.12.037","volume":"37","author":"Nobutoshi Nawa","year":"2019","unstructured":"Nawa, N. & Fujiwara, T. Association between social capital and second dose of measles vaccination in Japan: Results from the A-CHILD study. Vaccine, https:\/\/doi.org\/10.1016\/j.vaccine.2018.12.037 (2019).","journal-title":"Vaccine"},{"key":"47730_CR29","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3389\/fpsyt.2018.00192","volume":"9","author":"S Doi","year":"2018","unstructured":"Doi, S., Fujiwara, T., Isumi, A., Ochi, M. & Kato, T. Relationship Between Leaving Children at Home Alone and Their Mental Health: Results From the A-CHILD Study in Japan. Front Psychiatry 9, 192, https:\/\/doi.org\/10.3389\/fpsyt.2018.00192 (2018).","journal-title":"Front Psychiatry"},{"key":"47730_CR30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.sleep.2017.12.015","volume":"45","author":"S Doi","year":"2018","unstructured":"Doi, S., Fujiwara, T., Ochi, M., Isumi, A. & Kato, T. Association of sleep habits with behavior problems and resilience of 6- to 7-year-old children: results from the A-CHILD study. Sleep Med 45, 62\u201368, https:\/\/doi.org\/10.1016\/j.sleep.2017.12.015 (2018).","journal-title":"Sleep Med"},{"key":"47730_CR31","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3389\/fped.2018.00134","volume":"6","author":"Y Tani","year":"2018","unstructured":"Tani, Y., Fujiwara, T., Ochi, M., Isumi, A. & Kato, T. Does Eating Vegetables at Start of Meal Prevent Childhood Overweight in Japan? A-CHILD Study. Front Pediatr 6, 134, https:\/\/doi.org\/10.3389\/fped.2018.00134 (2018).","journal-title":"Front Pediatr"},{"key":"47730_CR32","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3389\/fped.2018.00179","volume":"6","author":"M Kizuki","year":"2018","unstructured":"Kizuki, M., Ochi, M., Isumi, A., Kato, T. & Fujiwara, T. Parental Time of Returning Home From Work and Child Mental Health Among First-Year Primary School Students in Japan: Result From A-CHILD Study. Front Pediatr 6, 179, https:\/\/doi.org\/10.3389\/fped.2018.00179 (2018).","journal-title":"Front Pediatr"},{"key":"47730_CR33","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/cdoe.12387","volume":"46","author":"Y Matsuyama","year":"2018","unstructured":"Matsuyama, Y., Fujiwara, T., Ochi, M., Isumi, A. & Kato, T. Self-control and dental caries among elementary school children in Japan. Community Dent Oral Epidemiol 46, 465\u2013471, https:\/\/doi.org\/10.1111\/cdoe.12387 (2018).","journal-title":"Community Dent Oral Epidemiol"},{"key":"47730_CR34","first-page":"1","volume":"26","author":"The Japanese Society of Pedodontics","year":"1988","unstructured":"The Japanese Society of Pedodontics. The chronology of deciduous and permanent dentition in Japanese children. The Japanese Society of Pedodontics. Shoni Shikagaku Zasshi 26, 1\u201318 (1988).","journal-title":"Shoni Shikagaku Zasshi"},{"key":"47730_CR35","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1177\/0002716214526530","volume":"654","author":"RE Dunifon","year":"2014","unstructured":"Dunifon, R. E., Zio-Guest, K. M. & Kopko, K. Grandparent coresidence and family well-being: implications for research and policy. The ANNALS of the American Academy of Political and Social Science 654, 110\u2013126 (2014).","journal-title":"The ANNALS of the American Academy of Political and Social Science"},{"key":"47730_CR36","unstructured":"Pitts, N. C. B. & Anderson, T. Children\u2019s dental health survey 2013. Report 2: dental disease and damage in children England, Wales and Northern Ireland., 106 (The Health and Social Care Information Centre, 2015)."},{"key":"47730_CR37","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1177\/00220345000790031501","volume":"79","author":"ML Mattila","year":"2000","unstructured":"Mattila, M. L., Rautava, P., Sillanpaa, M. & Paunio, P. Caries in five-year-old children and associations with family-related factors. J Dent Res 79, 875\u2013881, https:\/\/doi.org\/10.1177\/00220345000790031501 (2000).","journal-title":"J Dent Res"},{"key":"47730_CR38","doi-asserted-by":"publisher","first-page":"187","DOI":"10.4103\/2249-4863.154628","volume":"4","author":"K Sahoo","year":"2015","unstructured":"Sahoo, K. et al. Childhood obesity: causes and consequences. J Family Med Prim Care 4, 187\u2013192, https:\/\/doi.org\/10.4103\/2249-4863.154628 (2015).","journal-title":"J Family Med Prim Care"},{"key":"47730_CR39","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/cdep.12016","volume":"7","author":"RE Dunifon","year":"2013","unstructured":"Dunifon, R. E. The influence of grandparents on the lives of children and adolescents. Child Development Perspectives 7, 55\u201360 (2013).","journal-title":"Child Development Perspectives"},{"key":"47730_CR40","first-page":"739","volume":"10","author":"JP Carlos","year":"1965","unstructured":"Carlos, J. P. & Gittelsohn, A. M. Longitudinal studies of the natural history of caries. II. A life-table study of caries incidence in the permanent teeth. Arch Oral Biol 10, 739\u2013751 (1965).","journal-title":"A life-table study of caries incidence in the permanent teeth. Arch Oral Biol"},{"key":"47730_CR41","doi-asserted-by":"publisher","first-page":"563","DOI":"10.2188\/jea.JE20150255","volume":"26","author":"Y Matsuyama","year":"2016","unstructured":"Matsuyama, Y. et al. School-Based Fluoride Mouth-Rinse Program Dissemination Associated With Decreasing Dental Caries Inequalities Between Japanese Prefectures: An Ecological Study. Journal of epidemiology 26, 563\u2013571, https:\/\/doi.org\/10.2188\/jea.JE20150255 (2016).","journal-title":"Journal of epidemiology"},{"key":"47730_CR42","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/cdoe.12304","volume":"45","author":"J Aida","year":"2017","unstructured":"Aida, J. et al. Trajectory of social inequalities in the treatment of dental caries among preschool children in Japan. Community dentistry and oral epidemiology 45, 407\u2013412, https:\/\/doi.org\/10.1111\/cdoe.12304 (2017).","journal-title":"Community dentistry and oral epidemiology"},{"key":"47730_CR43","unstructured":"Chan, K. et al. The Effectiveness of Interventions for Grandparents Raising Grandchildren: A Meta-Analysis. Research on Social Work Practice, 1\u201311 (2018)."},{"key":"47730_CR44","first-page":"89","volume":"105","author":"JA Neergaard","year":"1990","unstructured":"Neergaard, J. A. A proposal for a foster grandmother intervention program to prevent child abuse. Public Health Rep 105, 89\u201393 (1990).","journal-title":"Public Health Rep"},{"key":"47730_CR45","unstructured":"American Academy of Pediatric Dentistry Clinical Affairs, C. Policy on Dietary Recommendations for Infants, Children, and Adolescents. Pediatr Dent 39, 64\u201366 (2017)."},{"key":"47730_CR46","unstructured":"Policy on Early Childhood Caries (ECC): Classifications, Consequences, and Preventive Strategies. Pediatr Dent 39, 59\u201361 (2017)."},{"key":"47730_CR47","unstructured":"Japanese School Health Association. (2016)."},{"key":"47730_CR48","first-page":"379","volume":"20","author":"WHG Logan","year":"1933","unstructured":"Logan, W. H. G. & Kronfeld, R. Development of the human jaws and surrounding structures from birth to the age of fifteen years. The Journal of the American Dental Association 20, 379\u2013427 (1933).","journal-title":"The Journal of the American Dental Association"},{"key":"47730_CR49","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1600-051X.1994.tb00320.x","volume":"21","author":"JC Gunsolley","year":"1994","unstructured":"Gunsolley, J. C., Williams, D. A. & Schenkein, H. A. Variance Component Modeling of Attachment Level Measurements. J Clin Periodontol 21, 289\u2013295, https:\/\/doi.org\/10.1111\/j.1600-051X.1994.tb00320.x (1994).","journal-title":"J Clin Periodontol"},{"key":"47730_CR50","doi-asserted-by":"publisher","first-page":"4139","DOI":"10.1002\/sim.2859","volume":"26","author":"G Burnside","year":"2007","unstructured":"Burnside, G., Pine, C. M. & Williamson, P. R. The application of multilevel modelling to dental caries data. Stat Med 26, 4139\u20134149, https:\/\/doi.org\/10.1002\/sim.2859 (2007).","journal-title":"Stat Med"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-47730-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-47730-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-47730-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T12:14:31Z","timestamp":1671279271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-47730-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,5]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["47730"],"URL":"https:\/\/doi.org\/10.1038\/s41598-019-47730-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,5]]},"assertion":[{"value":"26 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"11345"}}