{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:29:55Z","timestamp":1793968195101,"version":"4.8.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Kidney Donor Profile Index (KDPI) was introduced in the United States in 2014 to guide the decision making of clinicians with respect to accepting or declining a donated kidney. To evaluate whether the KDPI can be applied to a European cohort, we retrospectively assessed 580 adult patients who underwent renal transplantation (brain-dead donors) between January 2007 and December 2014 at our center and compared their KDPIs with their short- and long-term outcomes. This led to the observation of two associations: one between the KDPI and the estimated glomerular filtration rate at one year (1-y-eGFR) and the other between the KDPI and the death-censored allograft survival rate (both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Following this, the individual input factors of the KDPI were analyzed to assess their potential to evaluate the quality of a donor organ. We found that a donor\u2019s age alone is significantly predictive in terms of 1-y-eGFR and death-censored allograft survival (both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Therefore, a donor\u2019s age may serve as a simple reference for future graft function. Furthermore, we found that an organ with a low KDPI or from a young donor has an improved graft survival rate whereas kidneys with a high KDPI or from an older donor yield an inferior performance, but they are still acceptable. Therefore, we would not encourage defining a distinct KDPI cut-off in the decision-making process of accepting or declining a kidney graft.\n                  <\/jats:p>","DOI":"10.1038\/s41598-019-47772-7","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T07:19:54Z","timestamp":1564730394000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Validation of the Kidney Donor Profile Index (KDPI) to assess a deceased donor\u2019s kidneys\u2019 outcome in a European cohort"],"prefix":"10.1038","volume":"9","author":[{"given":"Maximilian","family":"Dahmen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Pavenst\u00e4dt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Suwelack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Sch\u00fctte-N\u00fctgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Reuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"47772_CR1","unstructured":"United States Renal Data System. 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Donor characteristics associated with reduced graft survival: an approach to expanding the pool of kidney donors. Transplantation. 74, 1281\u20131286 (2002).","journal-title":"Transplantation."},{"key":"47772_CR19","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s00467-011-1843-8","volume":"26","author":"JF Betram","year":"2011","unstructured":"Betram, J. F. et al. Human nephron number: implications for health and disease. Pediatr Nephrol. 26, 1529\u20131533 (2011).","journal-title":"Pediatr Nephrol."},{"key":"47772_CR20","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1111\/j.1600-6143.2012.04146.x","volume":"12","author":"KJ Woodside","year":"2012","unstructured":"Woodside, K. J. et al. Utilization of kidneys with similar Kidney Donor Risk Index values from standard versus expanded criteria donors. 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