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Placental ATP-binding cassette (ABC) transporters mediate the efflux of nutrients, cytokines and xenobiotics.\u00a0The expression and activity of these transporters are highly responsive to infection. We hypothesized that MiP would perturb the expression of placental ABC transporters, promoting PTD. Peripheral\u00a0blood, spleens, livers and placentas of pregnant mice, infected with <jats:italic>Plasmodium berghei ANKA<\/jats:italic> on gestational day (GD) 13.5, were collected and analyzed on GD18.5. The primary consequences of human MiP, including IUGR, PTD (20%) and placental inflammation, were recapitulated in our mouse model. Electron microscopy revealed attenuated\u00a0presence of labyrinthine microvilli and dilated spongiotrophoblasts -granular endoplasmic reticulum cisternae. Additionally, a decrease in placental <jats:italic>Abca1 (<\/jats:italic>ABCA1), <jats:italic>Abcb1b (<\/jats:italic>P-glycoprotein), <jats:italic>Abcb9<\/jats:italic> and <jats:italic>Abcg2 (<\/jats:italic>BCRP) expression was observed in MiP mice. In conclusion, MiP associated with PTD impairs placental ABC transporters\u2019 expression, potentially modulating placental nutrient, environmental toxin and xenobiotic biodistribution within the fetal compartment, and may, at some degree, be involved with pregnancy outcome in MiP.<\/jats:p>","DOI":"10.1038\/s41598-019-47865-3","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T10:02:56Z","timestamp":1565172176000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor"],"prefix":"10.1038","volume":"9","author":[{"given":"K. 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