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Contrast sensitivity isocontours (CSIs) may reduce test variability in SAP by identifying regions of the visual field with statistically similar patterns of change that can be analysed collectively and allow a point (disease)-to-CSI (normal) comparison in disease assessment as opposed to a point (disease)-to-point (normal) comparison. CSIs in the central visual field however have limited applicability as they have only been described using visual field test patterns with low, 6\u00b0 spatial sampling. In this study, CSIs were determined within the central 20\u00b0 visual field using the 10-2 test grid paradigm of the Humphrey Field Analyzer which has a high 2\u00b0 sampling frequency. The number of CSIs detected in the central 20\u00b0 visual field was greater than previously reported with low spatial sampling and stimulus size dependent: 6 CSIs for GI, 4 CSIs for GII and GIII, and 3 CSIs for GIV and GV. CSI number and distribution were preserved with age. Use of CSIs to assess visual function in age-related macular degeneration (AMD) found CSI guided analysis detected a significantly greater deviation in sensitivity of AMD eyes from normal compared to a standard clinical pointwise comparison (\u22121.40\u2009\u00b1\u20090.15\u2009dB vs \u22120.96\u2009\u00b1\u20090.15\u2009dB; p\u2009&lt;\u20090.05). This work suggests detection of CSIs within the central 20\u00b0 is dependent on sampling strategy and stimulus size and normative distribution limits of CSIs can indicate significant functional deficits in diseases affecting the central visual field such as AMD.<\/jats:p>","DOI":"10.1038\/s41598-019-48026-2","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T10:03:02Z","timestamp":1565604182000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Contrast sensitivity isocontours of the central visual field"],"prefix":"10.1038","volume":"9","author":[{"given":"Agnes Y. 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Khuu and M. Kalloniatis are named inventors on a patent involving the use of different Goldmann target sizes at different visual field locations for contrast sensitivity testing (International Publication Number WO 2014\/094035 A1 (USA) and European Patent Number: 13865419.9). All other authors have declared no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"11603"}}