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We have reported a switching system in <jats:italic>C<\/jats:italic>. <jats:italic>tropicalis<\/jats:italic> consisting of five morphotypes \u2013 the parental, switch variant (crepe and rough), and revertant (crepe and rough) strains, which exhibited altered virulence in a <jats:italic>Galleria mellonella<\/jats:italic> model. Here, we evaluate whether switching events may alter host-pathogen interactions by comparing the attributes of the innate responses to the various states. All switched strains induced higher melanization in <jats:italic>G<\/jats:italic>. <jats:italic>mellonella<\/jats:italic> larvae than that induced by the parental strain. The galiomicin expression was higher in the larvae infected with the crepe and rough morphotypes than that in the larvae infected with the parental strain. Hemocytes preferentially phagocytosed crepe variant cells over parental cells <jats:italic>in vitro<\/jats:italic>. In contrast, the rough variant cells were less phagocytosed than the parental strain. The hemocyte density was decreased in the larvae infected with the crepe variant compared to that in the larvae infected with the parental strain. Interestingly, larvae infected with the revertant of crepe restored the hemocyte density levels that to those observed for larvae infected with the parental strain. Most of the switched strains were more resistant to hemocyte candidacidal activity than the parental strain. These results indicate that the switch states exhibit similarities as well as important differences during infection in a <jats:italic>G<\/jats:italic>. <jats:italic>mellonella<\/jats:italic> model.<\/jats:p>","DOI":"10.1038\/s41598-019-49080-6","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T10:03:26Z","timestamp":1567073006000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Phenotypic switching in Candida tropicalis alters host-pathogen interactions in a Galleria mellonella infection model"],"prefix":"10.1038","volume":"9","author":[{"given":"Hugo F.","family":"Perini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alane T. 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