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The present study investigated the dysbiosis and mucins production in CD patients during remission. We performed an analytical cross-sectional single center study, which recruited 18 CD patients and 18 healthy controls (CG) residing in the same home, meaning that all of the participants experienced the same environmental factors, with similar hygiene status, diet, pollution and other common lifestyle characteristics that may influence the composition of the gut microbiota. When compared to healthy controls, the CD patients exhibited lower microbial \u03b1-diversity (p\u2009=\u20090.047), a greater abundance of the Proteobacteria phylum (p\u2009=\u20090.037) and a reduction in the Deltaproteobacteria class (p\u2009=\u20090.0006). There was also a reduction in the <jats:italic>Akkermansia<\/jats:italic> (p\u2009=\u20090.002) and <jats:italic>Oscillospira<\/jats:italic> (p\u2009=\u20090.024) genera and in the proportion of the yeast <jats:italic>Saccharomyces cerevisiae<\/jats:italic> (p\u2009=\u20090.01). Additionally, CD patients in remission presented increased neutral (p\u2009=\u20090.001) and acid mucin (p\u2009=\u20090.002) concentrations. The reductions in the proportions of <jats:italic>Oscollospira<\/jats:italic> and <jats:italic>Akkermansia<\/jats:italic> genera, sulfate-reducing bacteria and <jats:italic>Saccharomyces cerevisiae<\/jats:italic>, observed in the CD group, may account for the increased mucins production observed in these patients.<\/jats:p>","DOI":"10.1038\/s41598-019-49893-5","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T10:03:52Z","timestamp":1568369032000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Remission in Crohn\u2019s disease is accompanied by alterations in the gut microbiota and mucins production"],"prefix":"10.1038","volume":"9","author":[{"given":"Dani\u00e9la Oliveira","family":"Magro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2922-3032","authenticated-orcid":false,"given":"Andrey","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dioze","family":"Guadagnini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Moreira","family":"de Godoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia Helena Monteiro","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-6148","authenticated-orcid":false,"given":"Wilson Jos\u00e9 Fernandes","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-0747","authenticated-orcid":false,"given":"Nicola","family":"Vitulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Torriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Vital","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Augusto Real","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Jos\u00e9 Abdalla","family":"Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Saddy Rodrigues","family":"Coy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"49893_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ajpath.2014.09.010","volume":"185","author":"T Tsukahara","year":"2015","unstructured":"Tsukahara, T. et al. 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