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This 3D computer-assisted study measured the proximal ramus segment rotation after 3D simulation-guided two-jaw surgery in patients with facial asymmetric deformity and class III malocclusion (n\u2009=\u200931). Using 3D mandible models and a reliable proximal ramus segment-related plane, angular changes in pitch, roll and yaw directions were measured before and one month after surgery. Significant rotational changes (p\u2009&lt;\u20090.01) were observed in the left and right sides and overall proximal ramus segments after surgery, with absolute differences of 4.1\u2009\u00b1\u20093.0 (range \u22127.8 to 6.9), 2.8\u2009\u00b1\u20092.3 (\u22128.8 to 5.0), and 2.7\u2009\u00b1\u20092.4 (\u22126.6 to 9.9) degrees in pitch, roll, and yaw rotations, respectively. Numbness and mouth opening limiting occurred within the first 6 months after surgery but the patients had an unremarkable long-term postoperative course, with no revisionary surgery required. This study contributes to the multidisciplinary-related literature by revealing that proximal ramus segment rotation and rigid fixation with no postoperative intermaxillary immobilization was practicable in skeletofacial surgery for the successful treatment of asymmetric deformity and class III malocclusion.<\/jats:p>","DOI":"10.1038\/s41598-019-49946-9","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T10:05:08Z","timestamp":1568628308000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The outcome of skeletofacial reconstruction with mandibular rotation for management of asymmetric skeletal class III deformity: A three-dimensional computer-assisted investigation"],"prefix":"10.1038","volume":"9","author":[{"given":"Ting-Yu","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-3480","authenticated-orcid":false,"given":"Rafael","family":"Denadai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Hsia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Ting","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lun-Jou","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"49946_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02250-w","volume":"7","author":"D Lonic","year":"2017","unstructured":"Lonic, D., Sundoro, A., Lin, H. 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