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Acne drugs target one or more of these steps, with antibiotics commonly used to treat the microbial infection for moderate to severe cases. Whilst a number of other acne therapies are purported to possess antimicrobial activity, this has been poorly documented in many cases. We conducted a comparative analysis of the activity of common topical acne drugs against the principal etiological agent associated with acne: the aerotolerant anaerobic Gram-positive organism <jats:italic>Propionibacterium acnes<\/jats:italic> (recently renamed as <jats:italic>Cutibacterium acnes<\/jats:italic>). We also assessed their impact on other bacteria that could also be affected by topical treatments, including both antibiotic-sensitive and antibiotic-resistant strains, using broth microdilution assay conditions. Drugs designated specifically as antibiotics had the greatest potency, but lost activity against resistant strains. The non-antibiotic acne agents did possess widespread antimicrobial activity, including against resistant strains, but at substantially higher concentrations. Hence, the antimicrobial activity of non-antibiotic acne agents may provide protection against a background of increased drug-resistant bacteria.<\/jats:p>","DOI":"10.1038\/s41598-019-50746-4","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T10:40:39Z","timestamp":1570704039000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["In vitro Antimicrobial Activity of Acne Drugs Against Skin-Associated Bacteria"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9447-2292","authenticated-orcid":false,"given":"Mark A. 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