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We used data from the Live Births Information System (SINASC) in S\u00e3o Paulo state, Brazil, from 2005 to 2016. Trends of prevalence were evaluated for the specific subgroups using the Prais\u2013Winsten regression model, and the Durbin\u2013Watson test was used, to estimate the regression coefficient, the annual percent change (APC), and 95% confidence interval (CI). We observed 1576 cases of gastroschisis among 7,317,657 live births (LB), a prevalence of 2.154 (95% CI: 2.047\u20132.260) per 10,000 LB which included, 50.6% males, 67.4% Caucasians, 53.4% preterm births, and 80.9% caesarean births. The prevalence of gastroschisis significantly increased by 2.6% (95% CI: 0.0\u20135.2) per year, and this trend was higher in mothers aged 30\u201334 years (APC: 10.2, 95% CI: 1.4\u201319.4) than in mothers of other age groups. Between 2011 and 2016, we identified the existence of seasonality based on the date of conception in the middle months of the year (p\u2009=\u20090.002). This is the first and largest population\u2013based study summarizing current epidemiology and identifying trend of prevalence of gastroschisis in S\u00e3o Paulo state.<\/jats:p>","DOI":"10.1038\/s41598-019-50935-1","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T10:32:32Z","timestamp":1570703552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Increasing prevalence, time trend and seasonality of gastroschisis in S\u00e3o Paulo state, Brazil, 2005\u20132016"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-4363","authenticated-orcid":false,"given":"Mauricio Giusti","family":"Calderon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-337X","authenticated-orcid":false,"given":"Edige Felipe de Sousa","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7618-2109","authenticated-orcid":false,"given":"Luiz Carlos de","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-0728","authenticated-orcid":false,"given":"Rodrigo Daminello","family":"Raimundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"50935_CR1","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jpeds.2017.06.013","volume":"188","author":"BS Fullerton","year":"2017","unstructured":"Fullerton, B. 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