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Studies investigating factors related to the health-related quality of life (HRQOL) of children with atopic dermatitis and their caregivers are limited. This cross-sectional study included 559 children (&lt;16 years) with atopic dermatitis and their caregivers. Disease severity was associated with infants\u2019 HRQOL (moderate: IRR: 1.42, 95% CI 1.20\u20131.67; severe: IRR: 1.72, 95% CI 1.32\u20132.24). Age and disease severity were associated with children\u2019s HRQOL (age: IRR: 0.99, 95% CI 0.98\u20131.00; moderate: IRR: 1.08, 95% CI 1.02\u20131.14). Quality of life subdomains itching\/scratching, emotional distress and sleep disturbance were most reported and increased with higher disease severity. Both caregivers\u2019 mental and physical health were negatively affected by children\u2019s HRQOL (physical: IRR: 0.99, 95% CI 0.99\u20131.00; mental: IRR: 0.98, 95% CI 0.97\u20130.99). Sociodemographic characteristics (gender, ethnicity, educational attainment of carers, number of children) did not demonstrate significance in children\u2019s HRQOL model. In conclusion, current atopic dermatitis diagnostics and treatment have to be extended to the factors influencing both children\u2019 as their caregivers\u2019 quality of life and adapting management accordingly. Itching\/scratching, emotional distress and sleep disturbance deserve attention. Sociodemographic characteristics in children\u2019s HRQOL models also merit attention in further research.<\/jats:p>","DOI":"10.1038\/s41598-019-51129-5","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T11:12:36Z","timestamp":1572952356000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Factors influencing quality of life in children with atopic dermatitis and their caregivers: a cross-sectional study"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-0591","authenticated-orcid":false,"given":"Xiaomeng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Sandra","family":"van Galen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Jean Aan","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Bajpai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Thng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yik Weng","family":"Yew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie Pui Yoong","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Alagappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krister Sven Ake","family":"J\u00e4rbrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8969-371X","authenticated-orcid":false,"given":"Josip","family":"Car","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"51129_CR1","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1111\/j.1365-2133.1995.tb16953.x","volume":"132","author":"MS Lewis-Jones","year":"1995","unstructured":"Lewis-Jones, M. 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