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This prospective randomized controlled trial aimed to compare perioperative outcomes and changes in electrolytes after hysteroscopic procedures between the manual infusion (MI) and the pump infusion (PI) methods for distending media infusion. One hundred consecutive women who had hysteroscopic procedures between December 2013 and February 2017 were recruited and randomly allocated to either the MI or PI group. The PI group was associated with an increased volume of infused fluid and collected fluid compared with the volumes of the MI group. Almost all serum electrolyte levels differed significantly between the baseline and postoperative values in both groups; however, no significant differences were noted between the groups. The change in potassium level was positively correlated with the volume of fluid deficit (Spearman\u2019s rho\u2009=\u20090.24, P\u2009=\u20090.03), whereas the change in calcium level was negatively correlated with the volume of fluid deficit (Spearman\u2019s rho\u2009=\u2009\u22120.26, P\u2009=\u20090.046). With no between-group differences in the changes in the other perioperative parameters and electrolytes, the MI method can be a good alternative for delivering distending media for hysteroscopic procedures.<\/jats:p>","DOI":"10.1038\/s41598-019-51252-3","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T12:15:56Z","timestamp":1571400956000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Manual versus Pump Infusion of Distending Media for Hysteroscopic Procedures: A Randomized Controlled Trial"],"prefix":"10.1038","volume":"9","author":[{"given":"Wan-Hua","family":"Ting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-9321","authenticated-orcid":false,"given":"Ho-Hsiung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-9564","authenticated-orcid":false,"given":"Sheng-Mou","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,18]]},"reference":[{"key":"51252_CR1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ogc.2010.05.006","volume":"37","author":"MG Munro","year":"2010","unstructured":"Munro, M. 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