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For river blindness, a major NTD targeted for elimination, there is a long history of using vector control to suppress transmission, but traditional larvicide-based approaches are limited in their utility. One innovative and sustainable approach, \u201cslash and clear\u201d, involves clearing vegetation from breeding areas, and recent field trials indicate that this technique very effectively reduces the biting density of <jats:italic>Simulium damnosum s.s<\/jats:italic>. In this study, we use a Bayesian data-driven mathematical modeling approach to investigate the potential impact of this intervention on human onchocerciasis infection. We develop<jats:underline>ed<\/jats:underline> a novel \u201cslash and clear\u201d model describing the effect of the intervention on seasonal black fly biting rates and couple<jats:underline>d<\/jats:underline> this with our population dynamics model of <jats:italic>Onchocerca volvulus<\/jats:italic> transmission. Our results indicate that supplementing annual drug treatments with \u201cslash and clear\u201d can significantly accelerate the achievement of onchocerciasis elimination. The efficacy of the intervention is not very sensitive to the timing of implementation, and the impact is meaningful even if vegetation is cleared only once per year. As such, this community-driven technique will represent an important option for achieving and sustaining <jats:italic>O. volvulus<\/jats:italic> elimination.<\/jats:p>","DOI":"10.1038\/s41598-019-51835-0","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T12:20:45Z","timestamp":1572006045000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Accelerating river blindness elimination by supplementing MDA with a vegetation \u201cslash and clear\u201d vector control strategy: a data-driven modeling analysis"],"prefix":"10.1038","volume":"9","author":[{"given":"Morgan E.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shakir","family":"Bilal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomson L.","family":"Lakwo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peace","family":"Habomugisha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edridah","family":"Tukahebwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson","family":"Byamukama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses N.","family":"Katabarwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank O.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eddie W.","family":"Cupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Unnasch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"51835_CR1","unstructured":"World Health Organization. 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