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However, details of this relationship remain unclear, and the association of these polymorphisms with circulating IL-7\/IL-7R levels is scarce. Here, we explored whether IL-7\/IL-7R axis was associated with quantitative CD4<jats:sup>+<\/jats:sup> T-cell recovery in HIV-infected subjects. <jats:italic>IL-7\/IL-7R<\/jats:italic> polymorphisms were assessed by genotyping, and multiple inheritance models were used to estimate both, their association with low pre-ART CD4<jats:sup>+<\/jats:sup> T-cell counts and incomplete immune recovery status after 48 weeks of suppressive ART. Integrated data from genetic variants association and soluble plasma IL-7\/IL-7R quantification suggest that IL-7\/IL-7R genotype expression could alter the homeostatic balance between soluble and membrane-bound receptors. The haplotype analyses indicates that allele combinations impacts pre-ART circulating CD4<jats:sup>+<\/jats:sup> T-cell counts, immune recovery status and the absolute increment of CD4<jats:sup>+<\/jats:sup> T-cell counts. The knowledge about how IL-7\/IL-7R axis is related to quantitative CD4<jats:sup>+<\/jats:sup> T-cell recovery and immune recovery status after initiating ART could be useful regarding T-cell reservoirs investigations in HIV subjects.<\/jats:p>","DOI":"10.1038\/s41598-019-52025-8","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T11:08:43Z","timestamp":1572520123000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["IL-7\/IL-7R gene variants impact circulating IL-7\/IL-7R homeostasis and ART-associated immune recovery status"],"prefix":"10.1038","volume":"9","author":[{"given":"Andra","family":"Ceausu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Rodr\u00edguez-Gallego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Peraire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"L\u00f3pez-Dupla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Vilad\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Vidal-Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Peraire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carles","family":"Perpi\u00f1\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda Mar\u00eda","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi","family":"Veloso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Alba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso J.","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezequiel","family":"Ruiz-Mateos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Mallolas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"52025_CR1","doi-asserted-by":"publisher","first-page":"670957","DOI":"10.1155\/2012\/670957","volume":"2012","author":"JC Gaardbo","year":"2012","unstructured":"Gaardbo, J. 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