{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T06:13:59Z","timestamp":1759385639567,"version":"3.37.3"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Currently, acute lymphoblastic leukemia (ALL) has an overall survival of nearly 80% when it occurs in children, however cure rates among adults are far reduced. Leukemogenesis can be driven up by a slight change in the expression or function of certain transcription factors. CCAAT Enhancer Binding Protein Alpha (<jats:italic>CEBPA<\/jats:italic>) is a transcription factor with role in cell cycle regulation, granulocytic differentiation and more. Some studies suggest its oncogenic function. The potential role of <jats:italic>CEBPA<\/jats:italic> as an oncogene in ALL development has not been completely elucidated so far. Therefore, the aim of the present study was to evaluate mRNA level of <jats:italic>CEBPA<\/jats:italic> gene in 60 adult patients diagnosed with ALL. Quantitative analysis was performed by qPCR reaction. Analysis revealed that men tended to have higher and more variable <jats:italic>CEBPA<\/jats:italic> expression levels (<jats:italic>P<\/jats:italic>\u2009=\u2009<jats:italic>0.032<\/jats:italic>). No associations for other parameters (ALL subtype, age, leukocytosis, blast percentage, Philadelphia chromosome presence, CD10 marker presence) were found. When comparing the results of <jats:italic>CEBPA<\/jats:italic> expression with patients suffering from acute myeloid leukemia, ALL cases showed statistically significant lower levels of <jats:italic>CEBPA<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009<jats:italic>0.0000<\/jats:italic>). It may seem that <jats:italic>CEBPA<\/jats:italic> expression level itself has potentially no effect on arising and progression of acute lymphoblastic leukemia, although it is a matter that needs further investigation.<\/jats:p>","DOI":"10.1038\/s41598-019-52104-w","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T20:29:05Z","timestamp":1572467345000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Expression level of CEBPA gene in acute lymphoblastic leukemia individuals"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-6032","authenticated-orcid":false,"given":"Dagmara","family":"Szmajda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-1577","authenticated-orcid":false,"given":"Adrian","family":"Krygier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7207-8534","authenticated-orcid":false,"given":"Krzysztof","family":"Jamroziak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-7860","authenticated-orcid":false,"given":"Marta","family":"\u017bebrowska-Nawrocka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5257-2914","authenticated-orcid":false,"given":"Ewa","family":"Balcerczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"52104_CR1","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/S0140-6736(08)60457-2","volume":"371","author":"CH Pui","year":"2008","unstructured":"Pui, C. H., Robison, L. L. & Look, A. T. Acute lymphoblastic leukaemia. Lancet. 371, 1030\u201343, https:\/\/doi.org\/10.1016\/S0140-6736(08)60457-2 (2008).","journal-title":"Lancet."},{"issue":"6","key":"52104_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.53","volume":"7","author":"T Terwilliger","year":"2017","unstructured":"Terwilliger, T. & Abdul-Hay, M. Acute lymphoblastic leukemia: a comprehensive review and 2017 update. Blood Cancer J. 7(6), e577, https:\/\/doi.org\/10.1038\/bcj.2017.53 (2017).","journal-title":"Blood Cancer J."},{"doi-asserted-by":"publisher","unstructured":"Hoelzer, D. et al. on behalf of the ESMO Guidelines Committee. Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. 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