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Skeletonized manually segmented vascular networks from 15 healthy, 15 retinas with diabetic retinopathy (DR), and 15 retinas with glaucoma from publicly available High-Resolution Fundus (HRF) image database were used. When visualized by a digital fundus camera, O has a substantial proportion of small arteries and larger arterioles, while M contains smaller arterioles at the periphery and avascular zone in the center. We hypothesized that in pathological conditions the vascular network remodelling patterns in these two regions may be different. The analysis of box-counting fractal dimension (Db), lacunarity (\u039b), and microvascular density showed that in healthy retinas, \u039b and vessel density were lower in the M compared to the O, while the Db did not change. In retinas with DR, the Db was the lowest in the M, which was different from all other groups. The vessel density followed this trend. Lacunarity was the highest in the O of DR group compared to all other groups. The results show that in DR various regions of retinal microvascular network remodel in a different manner and to different extent.<\/jats:p>","DOI":"10.1038\/s41598-019-52659-8","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T14:48:06Z","timestamp":1573224486000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Regional Patterns in Retinal Microvascular Network Geometry in Health and Disease"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9769-1543","authenticated-orcid":false,"given":"Natasa","family":"Popovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stela","family":"Vujosevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomo","family":"Popovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"52659_CR1","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1097\/HJH.0b013e328347266c","volume":"29","author":"C Cheung","year":"2011","unstructured":"Cheung, C. et al. 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