{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T04:33:47Z","timestamp":1794285227075,"version":"4.9.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV infection, were co-housed with the vaccinated camels at a ratio of 1:2 (infected:vaccinated); nasal discharge and virus titres were monitored for 14 days. Overall, the vaccination reduced virus shedding and nasal discharge (p\u2009=\u20090.0059 and p\u2009=\u20090.0274, respectively). Antibody responses in seropositive camels were enhancedby the vaccine; these camels had a higher average age than seronegative. Older seronegative camels responded more strongly to vaccination than younger animals; and neutralising antibodies were detected in nasal swabs. Further work is required to optimise vaccine regimens for younger seronegative camels.<\/jats:p>","DOI":"10.1038\/s41598-019-52730-4","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T09:48:06Z","timestamp":1573206486000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels"],"prefix":"10.1038","volume":"9","author":[{"given":"Naif Khalaf","family":"Alharbi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Qasim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Almasoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haya A.","family":"Aljami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed W.","family":"Alenazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alhafufi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar S.","family":"Aldibasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8471-7011","authenticated-orcid":false,"given":"Anwar M.","family":"Hashem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy","family":"Kasem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed","family":"Albrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musaad","family":"Aldubaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Almansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7978-3815","authenticated-orcid":false,"given":"Nigel J.","family":"Temperton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Kupke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Abu-obaidah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alkarar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Kyu","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esam","family":"Azhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Lambe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Bayoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Aldowerij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman H.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6823-9750","authenticated-orcid":false,"given":"Sarah C.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan H.","family":"Balkhy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"52730_CR1","unstructured":"WHO. MERS-CoV. (2019)."},{"key":"52730_CR2","doi-asserted-by":"crossref","unstructured":"Korea Centers for Disease, C. & Prevention. Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea, 2015. Osong Public Heal. Res Perspect 6, 269\u2013278 (2015).","DOI":"10.1016\/j.phrp.2015.08.006"},{"key":"52730_CR3","doi-asserted-by":"publisher","unstructured":"Lorch, J. M. et al. Experimental infection of bats with Geomyces destructans causes white-nose syndrome. Nature, https:\/\/doi.org\/10.1038\/nature10590 (2011).","DOI":"10.1038\/nature10590"},{"key":"52730_CR4","doi-asserted-by":"crossref","unstructured":"Conzade, R. et al. Reported Direct and Indirect Contact with Dromedary Camels among Laboratory-Confirmed MERS-CoV Cases. Viruses 10 (2018).","DOI":"10.3390\/v10080425"},{"key":"52730_CR5","doi-asserted-by":"crossref","unstructured":"Kasem, S. et al. Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia. J. Infect. Public Health 11, 331\u2013338.","DOI":"10.1016\/j.jiph.2017.09.022"},{"key":"52730_CR6","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/S1473-3099(13)70164-6","volume":"13","author":"CBEM Reusken","year":"2013","unstructured":"Reusken, C. B. E. M. et al. Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. Lancet. Infect. Dis. 13, 859\u201366 (2013).","journal-title":"Lancet. Infect. Dis."},{"key":"52730_CR7","first-page":"41","volume":"3","author":"D Falzarano","year":"2017","unstructured":"Falzarano, D. et al. Dromedary camels in northern Mali have high seropositivity to MERS-CoV. One Heal. (Amsterdam, Netherlands) 3, 41\u201343 (2017).","journal-title":"One Heal. (Amsterdam, Netherlands)"},{"key":"52730_CR8","doi-asserted-by":"crossref","unstructured":"Miguel, E. et al. Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso, Ethiopia, and Morocco, 2015. Euro Surveill. 22 (2017).","DOI":"10.2807\/1560-7917.ES.2017.22.13.30498"},{"key":"52730_CR9","doi-asserted-by":"publisher","first-page":"e0140125","DOI":"10.1371\/journal.pone.0140125","volume":"10","author":"SL Deem","year":"2015","unstructured":"Deem, S. L. et al. Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County, Kenya. PLoS One 10, e0140125 (2015).","journal-title":"PLoS One"},{"key":"52730_CR10","doi-asserted-by":"crossref","unstructured":"Perera, R. A. et al. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, june 2013. Eurosurveillance 18 (2013).","DOI":"10.2807\/1560-7917.ES2013.18.36.20574"},{"key":"52730_CR11","doi-asserted-by":"publisher","unstructured":"Meyer, B. et al. Antibodies against MERS coronavirus in dromedaries, United Arab Emirates, 2003 and 2013. Emerg. Infect. Dis., https:\/\/doi.org\/10.3201\/eid2004.131746 (2014).","DOI":"10.3201\/eid2004.131746"},{"key":"52730_CR12","doi-asserted-by":"publisher","unstructured":"M\u00fcller, M. A. et al. Mers coronavirus neutralizing antibodies in camels, eastern Africa, 1983\u20131997. Emerg. Infect. Dis, https:\/\/doi.org\/10.3201\/eid2012.141026 (2014).","DOI":"10.3201\/eid2012.141026"},{"key":"52730_CR13","doi-asserted-by":"publisher","unstructured":"Corman, V. M. et al. Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992-2013. Emerg. Infect. Dis., https:\/\/doi.org\/10.3201\/eid2008.140596 (2014).","DOI":"10.3201\/eid2008.140596"},{"key":"52730_CR14","doi-asserted-by":"publisher","unstructured":"Reusken, C. B. E. M. et al. Geographic distribution of MERS coronavirus among dromedary camels, Africa. Emerg. Infect. Dis., https:\/\/doi.org\/10.3201\/eid2008.140590 (2014).","DOI":"10.3201\/eid2008.140590"},{"key":"52730_CR15","doi-asserted-by":"publisher","unstructured":"Hemida, M. G. et al. Seroepidemiology of middle east respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity. Eurosurveillance, https:\/\/doi.org\/10.2807\/1560-7917.ES2014.19.23.20828 (2014).","DOI":"10.2807\/1560-7917.ES2014.19.23.20828"},{"key":"52730_CR16","first-page":"e00884","volume":"5","author":"AN Alagaili","year":"2014","unstructured":"Alagaili, A. N. et al. Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia. MBio 5, e00884\u201314 (2014).","journal-title":"MBio"},{"key":"52730_CR17","doi-asserted-by":"publisher","unstructured":"Kasem, S. et al. The prevalence of Middle East respiratory Syndrome coronavirus (MERS-CoV) infection in livestock and temporal relation to locations and seasons. J. Infect. Public Health, https:\/\/doi.org\/10.1016\/j.jiph.2018.01.004 (2018).","DOI":"10.1016\/j.jiph.2018.01.004"},{"key":"52730_CR18","doi-asserted-by":"publisher","unstructured":"Chu, D. K. W. et al. MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity. Proc. Natl. Acad. Sci. USA, https:\/\/doi.org\/10.1073\/pnas.1718769115 (2018).","DOI":"10.1073\/pnas.1718769115"},{"key":"52730_CR19","doi-asserted-by":"publisher","unstructured":"Alshukairi, A. N. et al. High Prevalence of MERS-CoV Infection in Camel Workers in Saudi Arabia. Mbio, https:\/\/doi.org\/10.1128\/mBio.01985-18 (2018).","DOI":"10.1128\/mBio.01985-18"},{"key":"52730_CR20","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nature12328","volume":"500","author":"G Lu","year":"2013","unstructured":"Lu, G. et al. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature 500, 227\u201331 (2013).","journal-title":"Nature"},{"key":"52730_CR21","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nature12005","volume":"495","author":"VS Raj","year":"2013","unstructured":"Raj, V. S. et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 495, 251\u20134 (2013).","journal-title":"Nature"},{"key":"52730_CR22","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1080\/14760584.2018.1506702","volume":"17","author":"Y Zhou","year":"2018","unstructured":"Zhou, Y., Jiang, S. & Du, L. Prospects for a MERS-CoV spike vaccine. Expert Rev. Vaccines 17, 677\u2013686 (2018).","journal-title":"Expert Rev. Vaccines"},{"key":"52730_CR23","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.3389\/fmicb.2019.01781","volume":"10","author":"CY Yong","year":"2019","unstructured":"Yong, C. Y., Ong, H. K., Yeap, S. K., Ho, K. L. & Tan, W. S. Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus. Front. Microbiol. 10, 1781 (2019).","journal-title":"Front. Microbiol."},{"key":"52730_CR24","doi-asserted-by":"crossref","unstructured":"Alharbi, N. K. Vaccines against Middle East respiratory syndrome coronavirus for humans and camels. Rev Med Virol 27 (2016).","DOI":"10.1002\/rmv.1917"},{"key":"52730_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2016.130","volume":"6","author":"MA Ali","year":"2017","unstructured":"Ali, M. A. et al. Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt. Emerg. Microbes Infect. 6, e1 (2017).","journal-title":"Emerg. Microbes Infect."},{"key":"52730_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2017.44","volume":"6","author":"MG Hemida","year":"2017","unstructured":"Hemida, M. G. et al. Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014\u20132015. Emerg. Microbes Infect. 6, e56 (2017).","journal-title":"Emerg. Microbes Infect."},{"key":"52730_CR27","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.3201\/eid2212.160382","volume":"22","author":"B Meyer","year":"2016","unstructured":"Meyer, B. et al. Time Course of MERS-CoV Infection and Immunity in Dromedary Camels. Emerg. Infect. Dis. 22, 2171\u20132173 (2016).","journal-title":"Emerg. Infect. Dis."},{"key":"52730_CR28","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3201\/eid2007.140571","volume":"20","author":"MG Hemida","year":"2014","unstructured":"Hemida, M. G. et al. MERS coronavirus in dromedary camel herd, Saudi Arabia. Emerg. Infect. Dis. 20, 1231\u20134 (2014).","journal-title":"Emerg. Infect. Dis."},{"key":"52730_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2017.89","volume":"6","author":"MF Yusof","year":"2017","unstructured":"Yusof, M. F. et al. Diversity of Middle East respiratory syndrome coronaviruses in 109 dromedary camels based on full-genome sequencing, Abu Dhabi, United Arab Emirates. Emerg. Microbes Infect. 6, e101 (2017).","journal-title":"Emerg. Microbes Infect."},{"key":"52730_CR30","doi-asserted-by":"publisher","unstructured":"Alharbi, N. K. et al. ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice, https:\/\/doi.org\/10.1016\/j.vaccine.2017.05.032 (2017).","DOI":"10.1016\/j.vaccine.2017.05.032"},{"key":"52730_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-017-0029-1","volume":"2","author":"VJ Munster","year":"2017","unstructured":"Munster, V. J. et al. Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model. NPJ Vaccines 2, 28 (2017).","journal-title":"NPJ Vaccines"},{"key":"52730_CR32","doi-asserted-by":"publisher","first-page":"e40385","DOI":"10.1371\/journal.pone.0040385","volume":"7","author":"MD Dicks","year":"2012","unstructured":"Dicks, M. D. et al. A novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicity. PLoS One 7, e40385 (2012).","journal-title":"PLoS One"},{"key":"52730_CR33","doi-asserted-by":"crossref","unstructured":"Warimwe, G. M. et al. Chimpanzee adenovirus vaccine provides multispecies protection against rift valley fever. Sci. Rep. 6 (2016).","DOI":"10.1038\/srep20617"},{"key":"52730_CR34","doi-asserted-by":"publisher","unstructured":"Antrobus, R. D. et al. Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens. Mol. Ther., https:\/\/doi.org\/10.1038\/mt.2013.284 (2014).","DOI":"10.1038\/mt.2013.284"},{"key":"52730_CR35","doi-asserted-by":"publisher","unstructured":"Coughlan, L. et al. Heterologous Two-Dose Vaccination with Simian Adenovirus and Poxvirus Vectors Elicits Long-Lasting Cellular Immunity to Influenza Virus A in Healthy Adults. EbioMedicine, https:\/\/doi.org\/10.1016\/j.ebiom.2018.02.011 (2018).","DOI":"10.1016\/j.ebiom.2018.02.011"},{"key":"52730_CR36","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1126\/science.aad1283","volume":"351","author":"BL Haagmans","year":"2016","unstructured":"Haagmans, B. L. et al. An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels. Science (80-.). 351, 77\u201381 (2016).","journal-title":"Science (80-.)."},{"key":"52730_CR37","doi-asserted-by":"crossref","unstructured":"Perera, R. A. et al. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill 18, pii=20574 (2013).","DOI":"10.2807\/1560-7917.ES2013.18.36.20574"},{"key":"52730_CR38","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.3389\/fimmu.2019.01677","volume":"10","author":"HO Padilla-Quirarte","year":"2019","unstructured":"Padilla-Quirarte, H. O., Lopez-Guerrero, D. V., Gutierrez-Xicotencatl, L. & Esquivel-Guadarrama, F. Protective Antibodies Against Influenza Proteins. Front. Immunol. 10, 1677 (2019).","journal-title":"Front. Immunol."},{"key":"52730_CR39","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jim.2019.01.005","volume":"466","author":"AM Hashem","year":"2019","unstructured":"Hashem, A. M. et al. Development and validation of different indirect ELISAs for MERS-CoV serological testing. J. Immunol. Methods 466, 41\u201346 (2019).","journal-title":"J. Immunol. Methods"},{"key":"52730_CR40","doi-asserted-by":"crossref","unstructured":"Okba, N. M. A. et al. Sensitive and Specific Detection of Low-Level Antibody Responses in Mild Middle East Respiratory Syndrome Coronavirus Infections. Emerg. Infect. Dis. 25 (2019).","DOI":"10.3201\/eid2510.190051"},{"key":"52730_CR41","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.3201\/eid2012.141280","volume":"20","author":"DR Adney","year":"2014","unstructured":"Adney, D. R. et al. Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels. Emerg Infect Dis 20, 1999\u20132005 (2014).","journal-title":"Emerg Infect Dis"},{"key":"52730_CR42","doi-asserted-by":"publisher","unstructured":"Xiao, S., Li, Y., Sung, M., Wei, J. & Yang, Z. A study of the probable transmission routes of MERS-CoV during the first hospital outbreak in the Republic of Korea. Indoor Air, https:\/\/doi.org\/10.1111\/ina.12430 (2018).","DOI":"10.1111\/ina.12430"},{"key":"52730_CR43","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/nm.1850","volume":"14","author":"SJ Draper","year":"2008","unstructured":"Draper, S. J. et al. Effective induction of high-titer antibodies by viral vector vaccines. Nat Med 14, 819\u2013821 (2008).","journal-title":"Nat Med"},{"key":"52730_CR44","doi-asserted-by":"publisher","unstructured":"Hashem, A. M. et al. A highly immunogenic, protective and safe adenovirus-based vaccine expressing MERS-CoV S1-CD40L fusion protein in transgenic human DPP4 mouse model. J. Infect. Dis., https:\/\/doi.org\/10.1093\/infdis\/jiz137 (2019).","DOI":"10.1093\/infdis\/jiz137"},{"key":"52730_CR45","doi-asserted-by":"publisher","unstructured":"Grehan, K., Ferrara, F. & Temperton, N. An optimised method for the production of MERS-CoV spike expressing viral pseudotypes. MethodsX, https:\/\/doi.org\/10.1016\/j.mex.2015.09.003 (2015).","DOI":"10.1016\/j.mex.2015.09.003"},{"key":"52730_CR46","doi-asserted-by":"publisher","unstructured":"Volz, A. et al. Protective efficacy of recombinant Modified Vaccinia virus Ankara (MVA) delivering Middle East Respiratory Syndrome coronavirus spike glycoprotein. J Virol, https:\/\/doi.org\/10.1128\/JVI.00614-15 (2015).","DOI":"10.1128\/JVI.00614-15"},{"key":"52730_CR47","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1056\/NEJMoa1401505","volume":"370","author":"EI Azhar","year":"2014","unstructured":"Azhar, E. I. et al. Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med 370, 2499\u20132505 (2014).","journal-title":"N Engl J Med"},{"key":"52730_CR48","doi-asserted-by":"publisher","unstructured":"Corman, V. M. et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Eurosurveillance, https:\/\/doi.org\/10.2807\/ese.17.39.20285-en (2012).","DOI":"10.2807\/ese.17.39.20285-en"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-52730-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-52730-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-52730-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T10:38:05Z","timestamp":1671273485000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-52730-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,8]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["52730"],"URL":"https:\/\/doi.org\/10.1038\/s41598-019-52730-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,8]]},"assertion":[{"value":"22 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"SCG is a co-founder of and consultant to Vaccitech, a spin-out company from the University of Oxford which has commercial rights to ChAdOx1 MERS. ChAdOx1 MERS vaccine is registered as an IP, number: WO 2018\/215766. The remaining authors declare no potential conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16292"}}