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Corpora cavernosa (CC) is an extension of the vasculature. We hypothesize that NLRP3 plays a deleterious role in CC relaxation. Male C57BL\/6 (WT) and NLRP3 deficient (NLRP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice were used. Intracavernosal pressure (ICP\/MAP) measurement was performed. Functional responses were obtained from CC strips of WT and NLRP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice before and after MCC950 (NLRP3 inhibitor) or LPS\u2009+\u2009ATP (NLRP3 stimulation). NLRP3, caspase-1, IL-1\u03b2, eNOS, nNOS, guanylyl cyclase-\u03b21 (GC\u03b21) and PKG1 protein expressions were determined. ICP\/MAP and sodium nitroprusside (SNP)-induced relaxation in CC were decreased in NLRP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Caspase-1, IL-1\u03b2 and eNOS activity were increased, but PKG1 was reduced in CC of NLRP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    . MCC950 decreased non-adrenergic non-cholinergic (NANC), acetylcholine (ACh), and SNP-induced relaxation in WT mice. MCC950 did not alter NLRP3, caspase-1 and IL-1\u03b2, but reduced GC\u03b21 expression. Although LPS\u2009+\u2009ATP decreased ACh- and SNP-, it increased NANC-induced relaxation in CC from WT, but not from NLRP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. LPS\u2009+\u2009ATP increased NLRP3, caspase-1 and interleukin-1\u03b2 (IL-1\u03b2). Conversely, it reduced eNOS activity and GC\u03b21 expression. NLRP3 plays a dual role in CC relaxation, with its inhibition leading to impairment of nitric oxide-mediated relaxation, while its activation by LPS\u2009+\u2009ATP causes decreased CC sensitivity to NO and endothelium-dependent relaxation.\n                  <\/jats:p>","DOI":"10.1038\/s41598-019-52831-0","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T06:05:29Z","timestamp":1573106729000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation"],"prefix":"10.1038","volume":"9","author":[{"given":"Rafael S.","family":"Fais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda L.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila A.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan C.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fab\u00edola","family":"Mestriner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita C.","family":"Tostes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando S.","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"52831_CR1","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1098\/rsif.2007.0221","volume":"4","author":"D Udelson","year":"2007","unstructured":"Udelson, D. 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