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The aim of our study was to understand the short and long-term usefulness of cardiac implantable electronic devices in TTS patients.We constituted a collective of 142 patients in a bi-centric study diagnosed with TTS between 2003 and 2017. The patient groups, divided according to the treatment with (n\u2009=\u20099, 6.3%) or without cardiac devices (n\u2009=\u2009133, 93.7%), were followed-up to determine the importance of devices and its complications. One patient was treated with a permanent pacemaker, five patients with a wearable cardioverter defibrillator, two patients with a subcutaneous defibrillator and one patient with a transvenous defibrillator. Regular device check-up was documented in all patients, presenting an ongoing high-degree AV-block. Neither device complications nor life-threatening tachyarrhythmias were documented after acute TTS event. However, patients comprising the device group suffered significantly more often from a highly reduced EF (30\u2009\u00b1\u20097.7% versus 39.1\u2009\u00b1\u20099.7%; p\u2009&lt;\u20090.05), cardiogenic shock with use of inotropic agents (66.6% versus 16.6%; p\u2009&lt;\u20090.05) and cardiopulmonary resuscitation (44.4% versus 5.3%; p\u2009&lt;\u20090.05). Our data confirm the usefulness of pacemaker in TTS patients. However, the cardioverter defibrillator including wearable cardioverter defibrillator may not be recommended.<\/jats:p>","DOI":"10.1038\/s41598-019-52929-5","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T11:03:18Z","timestamp":1573556598000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Takotsubo syndrome and cardiac implantable electronic device therapy"],"prefix":"10.1038","volume":"9","author":[{"given":"Ibrahim","family":"El-Battrawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia W.","family":"Erath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzair","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Behnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Gietzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Borggrefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"52929_CR1","first-page":"203","volume":"21","author":"K Dote","year":"1991","unstructured":"Dote, K., Sato, H., Tateishi, H., Uchida, T. & Ishihara, M. 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Erath reports receiving consultant fees, travel support and lecture fees from ZOLL Medical, travel grants from Bayer Vital, St. Jude Medical\/Abbott, Novartis and lecture fees from Servier and Bayer and was a fellow of the Boston Scientific heart rhythm fellowship program.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16559"}}