{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:52:56Z","timestamp":1787003576456,"version":"build-2736575974"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Motor function deficit induced by white matter injury (WMI) is one of the most severe complications of intracerebral haemorrhage (ICH). The degree of WMI is closely related to the prognosis of patients after ICH. However, the current behavioural assessment of motor function used in the ICH mouse model is mainly based on that for ischaemic stroke and lacks the behavioural methods that accurately respond to WMI. Here, a series of easy-to-implement behavioural tests were performed to detect motor deficits in mice after ICH. The results showed that the grip strength test and the modified pole test not only can better distinguish the degree of motor dysfunction between different volumes of blood ICH models than the Basso Mouse Scale and the beam walking test but can also accurately reflect the severity of WMI characterized by demyelination, axonal swelling and the latency of motor-evoked potential delay induced by ICH. In addition, after ICH, the results of grip tests and modified pole tests, rather than the Basso Mouse Scale and the beam walking test, were worse than those observed after intraventricular haemorrhage (IVH), which was used as a model of brain haemorrhage in non-white matter areas. These results indicate that the grip strength test and the modified pole test have advantages in detecting the degree of motor deficit induced by white matter injury after ICH in mice.<\/jats:p>","DOI":"10.1038\/s41598-019-53263-6","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T06:02:12Z","timestamp":1574056932000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Modified behavioural tests to detect white matter injury- induced motor deficits after intracerebral haemorrhage in mice"],"prefix":"10.1038","volume":"9","author":[{"given":"Weixiang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-5977","authenticated-orcid":false,"given":"Zhengcai","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3916-186X","authenticated-orcid":false,"given":"Rong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-9138","authenticated-orcid":false,"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4489-9217","authenticated-orcid":false,"given":"Hua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"key":"53263_CR1","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1001\/jamaneurol.2015.4202","volume":"73","author":"S Kumar","year":"2016","unstructured":"Kumar, S., Selim, M., Marchina, S. & Caplan, L. R. Transient Neurological Symptoms in Patients With Intracerebral Hemorrhage. JAMA neurology 73, 316\u2013320, https:\/\/doi.org\/10.1001\/jamaneurol.2015.4202 (2016).","journal-title":"JAMA neurology"},{"key":"53263_CR2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/s1474-4422(11)70264-2","volume":"11","author":"JS Balami","year":"2012","unstructured":"Balami, J. S. & Buchan, A. M. Complications of intracerebral haemorrhage. The Lancet. Neurology 11, 101\u2013118, https:\/\/doi.org\/10.1016\/s1474-4422(11)70264-2 (2012).","journal-title":"The Lancet. Neurology"},{"key":"53263_CR3","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.3174\/ajnr.A1639","volume":"30","author":"Y Kusano","year":"2009","unstructured":"Kusano, Y. et al. Prediction of functional outcome in acute cerebral hemorrhage using diffusion tensor imaging at 3T: a prospective study. AJNR. American journal of neuroradiology 30, 1561\u20131565, https:\/\/doi.org\/10.3174\/ajnr.A1639 (2009).","journal-title":"AJNR. American journal of neuroradiology"},{"key":"53263_CR4","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.neures.2015.10.006","volume":"106","author":"M Hijioka","year":"2016","unstructured":"Hijioka, M. et al. Axonal dysfunction in internal capsule is closely associated with early motor deficits after intracerebral hemorrhage in mice. Neuroscience research 106, 38\u201346, https:\/\/doi.org\/10.1016\/j.neures.2015.10.006 (2016).","journal-title":"Neuroscience research"},{"key":"53263_CR5","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1097\/phm.0000000000000787","volume":"97","author":"S Jang","year":"2018","unstructured":"Jang, S., Kwon, Y. & Kwak, S. Change of an Injured Corticospinal Tract During 3 Weeks\u2019 Rehabilitation After Putaminal Hemorrhage. American journal of physical medicine & rehabilitation 97, e29\u2013e30, https:\/\/doi.org\/10.1097\/phm.0000000000000787 (2018).","journal-title":"American journal of physical medicine & rehabilitation"},{"key":"53263_CR6","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/s1474-4422(12)70104-7","volume":"11","author":"RF Keep","year":"2012","unstructured":"Keep, R. F., Hua, Y. & Xi, G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. The Lancet. Neurology 11, 720\u2013731, https:\/\/doi.org\/10.1016\/s1474-4422(12)70104-7 (2012).","journal-title":"The Lancet. Neurology"},{"issue":"5","key":"53263_CR7","doi-asserted-by":"publisher","first-page":"e0178803","DOI":"10.1371\/journal.pone.0178803","volume":"12","author":"Wei Wu","year":"2017","unstructured":"Wu, W. et al. Increased threshold of short-latency motor evoked potentials in transgenic mice expressing Channelrhodopsin-2. 12, e0178803, https:\/\/doi.org\/10.1371\/journal.pone.0178803 (2017).","journal-title":"PLOS ONE"},{"key":"53263_CR8","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s12975-015-0445-3","volume":"7","author":"MJ Joseph","year":"2016","unstructured":"Joseph, M. J., Caliaperumal, J. & Schlichter, L. C. After Intracerebral Hemorrhage, Oligodendrocyte Precursors Proliferate and Differentiate Inside White-Matter Tracts in the Rat Striatum. Translational stroke research 7, 192\u2013208, https:\/\/doi.org\/10.1007\/s12975-015-0445-3 (2016).","journal-title":"Translational stroke research"},{"key":"53263_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/6138424","volume":"2017","author":"Shilun Zuo","year":"2017","unstructured":"Zuo, S., Pan, P., Li, Q. & Chen, Y. White Matter Injury and Recovery after Hypertensive Intracerebral Hemorrhage. 2017, 6138424, https:\/\/doi.org\/10.1155\/2017\/6138424 (2017).","journal-title":"BioMed Research International"},{"key":"53263_CR10","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1080\/15548627.2017.1390636","volume":"14","author":"J Liu","year":"2018","unstructured":"Liu, J. et al. Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models. Autophagy 14, 845\u2013861, https:\/\/doi.org\/10.1080\/15548627.2017.1390636 (2018).","journal-title":"Autophagy"},{"key":"53263_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/srep42323","volume":"7","author":"H Takeshita","year":"2017","unstructured":"Takeshita, H. et al. Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice. Scientific reports 7, 42323, https:\/\/doi.org\/10.1038\/srep42323 (2017).","journal-title":"Scientific reports"},{"key":"53263_CR12","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1089\/neu.2006.23.635","volume":"23","author":"DM Basso","year":"2006","unstructured":"Basso, D. M. et al. Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. Journal of neurotrauma 23, 635\u2013659, https:\/\/doi.org\/10.1089\/neu.2006.23.635 (2006).","journal-title":"Journal of neurotrauma"},{"key":"53263_CR13","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3389\/fncel.2014.00338","volume":"8","author":"TR Doeppner","year":"2014","unstructured":"Doeppner, T. R., Kaltwasser, B., Bahr, M. & Hermann, D. M. Effects of neural progenitor cells on post-stroke neurological impairment-a detailed and comprehensive analysis of behavioral tests. Frontiers in cellular neuroscience 8, 338, https:\/\/doi.org\/10.3389\/fncel.2014.00338 (2014).","journal-title":"Frontiers in cellular neuroscience"},{"key":"53263_CR14","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bbr.2014.01.052","volume":"264","author":"PR Krafft","year":"2014","unstructured":"Krafft, P. R. et al. Correlation between subacute sensorimotor deficits and brain edema in two mouse models of intracerebral hemorrhage. Behavioural brain research 264, 151\u2013160, https:\/\/doi.org\/10.1016\/j.bbr.2014.01.052 (2014).","journal-title":"Behavioural brain research"},{"key":"53263_CR15","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1089\/neu.2015.4140","volume":"33","author":"E Redondo-Castro","year":"2016","unstructured":"Redondo-Castro, E., Navarro, X. & Garcia-Alias, G. Longitudinal Evaluation of Residual Cortical and Subcortical Motor Evoked Potentials in Spinal Cord Injured Rats. Journal of neurotrauma 33, 907\u2013916, https:\/\/doi.org\/10.1089\/neu.2015.4140 (2016).","journal-title":"Journal of neurotrauma"},{"key":"53263_CR16","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.wneu.2016.05.015","volume":"92","author":"MYS Kalani","year":"2016","unstructured":"Kalani, M. Y. S. Intraoperative Motor-Evoked Potential Monitoring as a Predictive Tool for Recovery From Spontaneous Intracerebral Hemorrhage. World neurosurgery 92, 546\u2013547, https:\/\/doi.org\/10.1016\/j.wneu.2016.05.015 (2016).","journal-title":"World neurosurgery"},{"key":"53263_CR17","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.wneu.2016.03.058","volume":"90","author":"T Ikedo","year":"2016","unstructured":"Ikedo, T. et al. Intraoperative Transcranial Motor-Evoked Potentials Predict Motor Function Outcome in Intracerebral Hemorrhage Surgery. World neurosurgery 90, 518\u2013523, https:\/\/doi.org\/10.1016\/j.wneu.2016.03.058 (2016).","journal-title":"World neurosurgery"},{"key":"53263_CR18","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1161\/CIRCULATIONAHA.116.021881","volume":"134","author":"XY Xiong","year":"2016","unstructured":"Xiong, X. Y. et al. Toll-Like Receptor 4\/MyD88-Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral Hemorrhage. Circulation 134, 1025\u20131038, https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.021881 (2016).","journal-title":"Circulation"},{"key":"53263_CR19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.neuroscience.2017.05.006","volume":"355","author":"T Mukai","year":"2017","unstructured":"Mukai, T. et al. Intravenous injection of umbilical cord-derived mesenchymal stromal cells attenuates reactive gliosis and hypomyelination in a neonatal intraventricular hemorrhage model. Neuroscience 355, 175\u2013187, https:\/\/doi.org\/10.1016\/j.neuroscience.2017.05.006 (2017).","journal-title":"Neuroscience"},{"key":"53263_CR20","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.neuron.2018.07.017","volume":"99","author":"F Wang","year":"2018","unstructured":"Wang, F. et al. Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia. Neuron 99, 689\u2013701.e685, https:\/\/doi.org\/10.1016\/j.neuron.2018.07.017 (2018).","journal-title":"Neuron"},{"key":"53263_CR21","doi-asserted-by":"publisher","unstructured":"Doyle, S. et al. Vesicular glutamate release from central axons contributes to myelin damage. 9, 1032, https:\/\/doi.org\/10.1038\/s41467-018-03427-1 (2018).","DOI":"10.1038\/s41467-018-03427-1"},{"key":"53263_CR22","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1002\/glia.23055","volume":"64","author":"S Schneider","year":"2016","unstructured":"Schneider, S. et al. Decrease in newly generated oligodendrocytes leads to motor dysfunctions and changed myelin structures that can be rescued by transplanted cells. Glia 64, 2201\u20132218, https:\/\/doi.org\/10.1002\/glia.23055 (2016).","journal-title":"Glia"},{"key":"53263_CR23","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1161\/01.STR.0000032302.91894.0F","volume":"33","author":"Y Hua","year":"2002","unstructured":"Hua, Y. et al. Behavioral tests after intracerebral hemorrhage in the rat. Stroke 33, 2478\u20132484 (2002).","journal-title":"Stroke"},{"key":"53263_CR24","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/bonekey.2015.101","volume":"4","author":"A Bonetto","year":"2015","unstructured":"Bonetto, A., Andersson, D. C. & Waning, D. L. Assessment of muscle mass and strength in mice. BoneKEy reports 4, 732, https:\/\/doi.org\/10.1038\/bonekey.2015.101 (2015).","journal-title":"BoneKEy reports"},{"key":"53263_CR25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0165-0270(95)00049-6","volume":"62","author":"JP Smith","year":"1995","unstructured":"Smith, J. P., Hicks, P. S., Ortiz, L. R., Martinez, M. J. & Mandler, R. N. Quantitative measurement of muscle strength in the mouse. Journal of neuroscience methods 62, 15\u201319 (1995).","journal-title":"Journal of neuroscience methods"},{"key":"53263_CR26","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cmet.2016.07.005","volume":"24","author":"DW Frederick","year":"2016","unstructured":"Frederick, D. W. et al. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell metabolism 24, 269\u2013282, https:\/\/doi.org\/10.1016\/j.cmet.2016.07.005 (2016).","journal-title":"Cell metabolism"},{"key":"53263_CR27","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s12640-018-9876-4","volume":"34","author":"K Socala","year":"2018","unstructured":"Socala, K. et al. Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice. Neurotoxicity research 34, 333\u2013346, https:\/\/doi.org\/10.1007\/s12640-018-9876-4 (2018).","journal-title":"Neurotoxicity research"},{"key":"53263_CR28","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s00221-014-4183-7","volume":"233","author":"S Bestmann","year":"2015","unstructured":"Bestmann, S. & Krakauer, J. W. The uses and interpretations of the motor-evoked potential for understanding behaviour. Experimental brain research 233, 679\u2013689, https:\/\/doi.org\/10.1007\/s00221-014-4183-7 (2015).","journal-title":"Experimental brain research"},{"key":"53263_CR29","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1177\/0271678x16666551","volume":"37","author":"M Li","year":"2017","unstructured":"Li, M. et al. Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 37, 2383\u20132395, https:\/\/doi.org\/10.1177\/0271678x16666551 (2017).","journal-title":"Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"key":"53263_CR30","doi-asserted-by":"publisher","first-page":"7301623","DOI":"10.1155\/2018\/7301623","volume":"2018","author":"A Scimemi","year":"2018","unstructured":"Scimemi, A. Astrocytes and the Warning Signs of Intracerebral Hemorrhagic Stroke. Neural plasticity 2018, 7301623, https:\/\/doi.org\/10.1155\/2018\/7301623 (2018).","journal-title":"Neural plasticity"},{"key":"53263_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/srep32935","volume":"6","author":"X Chu","year":"2016","unstructured":"Chu, X. et al. 24-hour-restraint stress induces long-term depressive-like phenotypes in mice. Scientific reports 6, 32935, https:\/\/doi.org\/10.1038\/srep32935 (2016).","journal-title":"Scientific reports"},{"key":"53263_CR32","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.bbr.2015.05.006","volume":"291","author":"V Vargas-Lopez","year":"2015","unstructured":"Vargas-Lopez, V., Torres-Berrio, A., Gonzalez-Martinez, L., Munera, A. & Lamprea, M. R. Acute restraint stress and corticosterone transiently disrupts novelty preference in an object recognition task. Behavioural brain research 291, 60\u201366, https:\/\/doi.org\/10.1016\/j.bbr.2015.05.006 (2015).","journal-title":"Behavioural brain research"},{"key":"53263_CR33","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1253\/circj.CJ-13-0811","volume":"78","author":"S Gotoh","year":"2014","unstructured":"Gotoh, S. et al. Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community. Circulation journal: official journal of the Japanese Circulation Society 78, 403\u2013409 (2014).","journal-title":"Circulation journal: official journal of the Japanese Circulation Society"},{"key":"53263_CR34","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1159\/000281108","volume":"63","author":"SY Kwak","year":"2010","unstructured":"Kwak, S. Y., Yeo, S. S., Choi, B. Y., Chang, C. H. & Jang, S. H. Corticospinal tract change in the unaffected hemisphere at the early stage of intracerebral hemorrhage: a diffusion tensor tractography study. European neurology 63, 149\u2013153, https:\/\/doi.org\/10.1159\/000281108 (2010).","journal-title":"European neurology"},{"key":"53263_CR35","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1179\/1743132815y.0000000050","volume":"37","author":"CY Cheng","year":"2015","unstructured":"Cheng, C. Y. et al. Motor outcome of deep intracerebral haemorrhage in diffusion tensor imaging: comparison of data from different locations along the corticospinal tract. Neurological research 37, 774\u2013781, https:\/\/doi.org\/10.1179\/1743132815y.0000000050 (2015).","journal-title":"Neurological research"},{"key":"53263_CR36","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nrneurol.2014.264","volume":"11","author":"S Urday","year":"2015","unstructured":"Urday, S. et al. Targeting secondary injury in intracerebral haemorrhage\u2013perihaematomal oedema. Nature reviews. Neurology 11, 111\u2013122, https:\/\/doi.org\/10.1038\/nrneurol.2014.264 (2015).","journal-title":"Nature reviews. Neurology"},{"key":"53263_CR37","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.expneurol.2015.05.011","volume":"272","author":"N Chaudhary","year":"2015","unstructured":"Chaudhary, N. et al. Diffusion tensor imaging in hemorrhagic stroke. Experimental neurology 272, 88\u201396, https:\/\/doi.org\/10.1016\/j.expneurol.2015.05.011 (2015).","journal-title":"Experimental neurology"},{"key":"53263_CR38","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1161\/strokeaha.117.018904","volume":"49","author":"H Ren","year":"2018","unstructured":"Ren, H. et al. Selective NLRP3 (Pyrin Domain-Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage. Stroke 49, 184\u2013192, https:\/\/doi.org\/10.1161\/strokeaha.117.018904 (2018).","journal-title":"Stroke"},{"key":"53263_CR39","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.1177\/0271678x17709186","volume":"37","author":"Q Li","year":"2017","unstructured":"Li, Q. et al. Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 37, 3110\u20133123, https:\/\/doi.org\/10.1177\/0271678x17709186 (2017).","journal-title":"Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"key":"53263_CR40","first-page":"233","volume":"1","author":"OA Meyer","year":"1979","unstructured":"Meyer, O. A., Tilson, H. A., Byrd, W. C. & Riley, M. T. A method for the routine assessment of fore- and hindlimb grip strength of rats and mice. Neurobehavioral toxicology 1, 233\u2013236 (1979).","journal-title":"Neurobehavioral toxicology"},{"key":"53263_CR41","doi-asserted-by":"publisher","first-page":"361ra139","DOI":"10.1126\/scitranslmed.aaf5504","volume":"8","author":"D Ryu","year":"2016","unstructured":"Ryu, D. et al. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Science translational medicine 8, 361ra139, https:\/\/doi.org\/10.1126\/scitranslmed.aaf5504 (2016).","journal-title":"Science translational medicine"},{"key":"53263_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10210","volume":"6","author":"T Gali Ramamoorthy","year":"2015","unstructured":"Gali Ramamoorthy, T. et al. The transcriptional coregulator PGC-1beta controls mitochondrial function and anti-oxidant defence in skeletal muscles. Nature communications 6, 10210, https:\/\/doi.org\/10.1038\/ncomms10210 (2015).","journal-title":"Nature communications"},{"issue":"23","key":"53263_CR43","doi-asserted-by":"publisher","first-page":"5634","DOI":"10.1523\/JNEUROSCI.0949-16.2017","volume":"37","author":"Anders Enjin","year":"2017","unstructured":"Enjin, A., Perry, S. & Hilscher, M. M. Developmental Disruption of Recurrent Inhibitory Feedback Results in Compensatory Adaptation in the Renshaw Cell-Motor Neuron Circuit. 37, 5634\u20135647, https:\/\/doi.org\/10.1523\/jneurosci.0949-16.2017 (2017).","journal-title":"The Journal of Neuroscience"},{"key":"53263_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1217-2","volume":"15","author":"JD Lee","year":"2018","unstructured":"Lee, J. D. et al. Complement components are upregulated and correlate with disease progression in the TDP-43(Q331K) mouse model of amyotrophic lateral sclerosis. Journal of neuroinflammation 15, 171, https:\/\/doi.org\/10.1186\/s12974-018-1217-2 (2018).","journal-title":"Journal of neuroinflammation"},{"key":"53263_CR45","first-page":"435","volume":"50","author":"N Ogawa","year":"1985","unstructured":"Ogawa, N., Hirose, Y., Ohara, S., Ono, T. & Watanabe, Y. A simple quantitative bradykinesia test in MPTP-treated mice. Research communications in chemical pathology and pharmacology 50, 435\u2013441 (1985).","journal-title":"Research communications in chemical pathology and pharmacology"},{"key":"53263_CR46","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s13311-016-0472-0","volume":"14","author":"JM Shefner","year":"2017","unstructured":"Shefner, J. M. Strength Testing in Motor Neuron Diseases. Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics 14, 154\u2013160, https:\/\/doi.org\/10.1007\/s13311-016-0472-0 (2017).","journal-title":"Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics"},{"key":"53263_CR47","doi-asserted-by":"publisher","first-page":"6750","DOI":"10.1007\/s12035-016-0195-6","volume":"54","author":"SS Nampoothiri","year":"2017","unstructured":"Nampoothiri, S. S., Potluri, T., Subramanian, H. & Krishnamurthy, R. G. Rodent Gymnastics: Neurobehavioral Assays in Ischemic Stroke. Molecular neurobiology 54, 6750\u20136761, https:\/\/doi.org\/10.1007\/s12035-016-0195-6 (2017).","journal-title":"Molecular neurobiology"},{"key":"53263_CR48","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/s0140-6736(16)32410-2","volume":"389","author":"DF Hanley","year":"2017","unstructured":"Hanley, D. F. et al. Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial. Lancet (London, England) 389, 603\u2013611, https:\/\/doi.org\/10.1016\/s0140-6736(16)32410-2 (2017).","journal-title":"Lancet (London, England)"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-53263-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-53263-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-53263-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T11:01:01Z","timestamp":1671274861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-53263-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,18]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["53263"],"URL":"https:\/\/doi.org\/10.1038\/s41598-019-53263-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,18]]},"assertion":[{"value":"10 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16958"}}