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We conducted a genome-wide analysis based on DNA adenine methyltransferase identification (DamID) and RNA sequencing strategies to investigate <jats:italic>CBX2<\/jats:italic> in the human granulosa cells. Functional analysis revealed that <jats:italic>CBX2<\/jats:italic> was upstream of genes contributing to ovarian function like folliculogenesis and steroidogenesis (i.e. <jats:italic>ESR1<\/jats:italic>, <jats:italic>NRG1<\/jats:italic>, <jats:italic>AKR1C1<\/jats:italic>, <jats:italic>PTGER<\/jats:italic>2, <jats:italic>BMP15<\/jats:italic>, <jats:italic>BMP<\/jats:italic>2, <jats:italic>FSHR<\/jats:italic> and <jats:italic>NTRK1\/<\/jats:italic>2). We identified <jats:italic>CBX2<\/jats:italic> regulated genes associated with polycystic ovary syndrome (PCOS) such as <jats:italic>TGF\u03b2<\/jats:italic>, <jats:italic>MAP3K<\/jats:italic>1<jats:italic>5<\/jats:italic> and <jats:italic>DKK1<\/jats:italic>, as well as genes implicated in premature ovarian failure (POF) (i.e. <jats:italic>POF1B<\/jats:italic>, <jats:italic>BMP15<\/jats:italic> and <jats:italic>HOXA13<\/jats:italic>) and the pituitary deficiency (i.e. <jats:italic>LHX4<\/jats:italic> and <jats:italic>KISS1<\/jats:italic>). Our study provided an excellent opportunity to identify genes surrounding <jats:italic>CBX2<\/jats:italic> in the ovary and might contribute to the understanding of ovarian physiopathology causing infertility in women.<\/jats:p>","DOI":"10.1038\/s41598-019-53370-4","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T11:04:13Z","timestamp":1574161453000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The transcriptional regulator CBX2 and ovarian function: A whole genome and whole transcriptome approach"],"prefix":"10.1038","volume":"9","author":[{"given":"Leila","family":"Bouazzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Sproll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Eid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Biason-Lauber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"53370_CR1","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1172\/JCI41350","volume":"120","author":"JS Richards","year":"2010","unstructured":"Richards, J. 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