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Computational fluid-particle dynamics (CFPD) has proven to be a reliable tool in characterizing aerosol transport in the upper airways, while Monte Carlo based radiation codes allow accurate simulation of radiation transport. The objective of this study is to numerically assess the radiation dosimetry due to particles decaying in the respiratory tract from environmental radioactive exposures by coupling CFPD with Monte Carlo N-Particle code, version 6 (MCNP6). A physiologically realistic mouth-lung model extending to the bifurcation generation G9 was used to simulate airflow and particle transport within the respiratory tract. Polydisperse aerosols with different distributions were considered, and deposition distribution of the inhaled aerosols on the internal airway walls was quantified. The deposition mapping of radioactive aerosols was then registered to the respiratory tract of an image-based whole-body adult male model (VIP-Man) to simulate radiation transport and energy deposition. Computer codes were developed for geometry visualization, spatial normalization, and source card definition in MCNP6. Spatial distributions of internal radiation dosimetry were compared for different radionuclides (<jats:sup>131<\/jats:sup>I, <jats:sup>134,137<\/jats:sup>Cs, <jats:sup>90<\/jats:sup>Sr-<jats:sup>90<\/jats:sup>Y, <jats:sup>103<\/jats:sup>Ru and <jats:sup>239,240<\/jats:sup>Pu) in terms of the radiation fluence, energy deposition density, and dose per decay.<\/jats:p>","DOI":"10.1038\/s41598-019-54040-1","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T11:02:49Z","timestamp":1574679769000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Radiation Dosimetry of Inhaled Radioactive Aerosols: CFPD and MCNP Transport Simulations of Radionuclides in the Lung"],"prefix":"10.1038","volume":"9","author":[{"given":"Khaled","family":"Talaat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-0759","authenticated-orcid":false,"given":"Jinxiang","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoenix","family":"Baldez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Hecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"54040_CR1","doi-asserted-by":"publisher","first-page":"11268","DOI":"10.1021\/es502590s","volume":"48","author":"MA Gonze","year":"2014","unstructured":"Gonze, M. 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