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The outcome of interest was Hamilton Anxiety Scale (HAMA). Weighted mean differences (WMD) were calculated to estimate the treatment effect at the confidence interval of 95%. League tables were generated using treatment effect, for all pairwise comparisons, where WMD\u2009&lt;\u20090 favors the column-defining treatment. Five studies were identified with a total of 524 participants receiving treatment with silexan 80\u2009mg and 121 participants taking silexan 160\u2009mg. The NMA results indicated that consumption of silexan 160\u2009mg resulted in higher decline of HAMA score [WMD \u22121.14 (\u22121.10, 3.39)] in comparison to silexan 80\u2009mg, placebo [\u22122.20 (\u22124.64, 0.24)] and paroxetine [\u22121.24 (\u22125.34, 2.85)]. The effect of silexan 80\u2009mg was observed to be same as that of paroxetine. Overall, silexan 160\u2009mg was noticed to be a more efficient treatment giving significant decline in HAMA score across other comparators. However, no improvements in HAMA score was observed for the group receiving lorazepam 0.5\u2009mg when compared to silexan 160\u2009mg, silexan 80\u2009mg, paroxetine 20\u2009mg, and placebo.<\/jats:p>","DOI":"10.1038\/s41598-019-54529-9","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T06:37:14Z","timestamp":1575268634000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Efficacy and safety of lavender essential oil (Silexan) capsules among patients suffering from anxiety disorders: A network meta-analysis"],"prefix":"10.1038","volume":"9","author":[{"given":"Wuan Shuen","family":"Yap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-2276","authenticated-orcid":false,"given":"Anton V.","family":"Dolzhenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahraa","family":"Jalal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0108-7833","authenticated-orcid":false,"given":"Muhammad Abdul","family":"Hadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir Mehmood","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"54529_CR1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.31887\/DCNS.2015.17.3\/bbandelow","volume":"17","author":"B Bandelow","year":"2015","unstructured":"Bandelow, B. & Michaelis, S. 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