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Here we present the results of a meta-analysis of the impact of osteoarthritis (OA) on cognitive decline and overall mortality. Across 7 independent datasets obtained in studies of populations in the USA, EU and Australia (NBER, NSHAP, TILDA, NACC, Kaiser Permanente, GRIM BOOKS, OAI, with a total of &gt;7\u2009\u00d7\u200910<jats:sup>7<\/jats:sup> profiles), OA cohorts demonstrated higher cognitive scores, later dementia onset as well as longer lifespan and lower age-specific all-cause mortality. Moreover, generalized OA with multiple localizations is associated with more significant reduction of mortality and dementia than a singly localized OA or no arthritis. In OA patients with younger ages, all-cause mortality was disproportionally reduced as compared to that in controls, while exponential term of Gompert\u2019z hazard function was increased, accelerating mortality accrual at later ages. Up to 8\u201310% of poly-osteoarthritic patients are predicted and observed to reach centenarian lifespan, while in matched non-OA population the same benchmark is reached by less than 1% of patients. These results point at a\u00a0possibility of life-extending and cognition preserving impacts of OA-conditioned immune system.<\/jats:p>","DOI":"10.1038\/s41598-019-54867-8","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T11:03:08Z","timestamp":1575889388000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Increased lifespan, decreased mortality, and delayed cognitive decline in osteoarthritis"],"prefix":"10.1038","volume":"9","author":[{"given":"Anatoly L.","family":"Mayburd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ancha","family":"Baranova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"54867_CR1","unstructured":"Prince, M. et al. 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