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Recognition of Pep-13 is assumed to occur by binding to a yet unknown plasma membrane-localized receptor kinase. The potato genes annotated to encode the co-receptor BAK1, <jats:italic>StSERK3A<\/jats:italic> and <jats:italic>StSERK3B<\/jats:italic>, are activated in response to Pep-13 treatment. Transgenic RNAi-potato plants with reduced expression of both SERK3A and SERK3B were generated. In response to Pep-13 treatment, the formation of reactive oxygen species and MAP kinase activation, observed in wild type plants, is highly reduced in <jats:italic>StSERK3A\/B<\/jats:italic>-RNAi plants, suggesting that StSERK3A\/B are required for perception of Pep-13 in potato. In contrast, defense gene expression is induced by Pep-13 in both control and StSERK3A\/B-depleted plants. Altered morphology of <jats:italic>StSERK3A\/B<\/jats:italic>-RNAi plants correlates with major shifts in metabolism, as determined by untargeted metabolite profiling. Enhanced levels of hydroxycinnamic acid amides, typical phytoalexins of potato, in <jats:italic>StSERK3A\/B-<\/jats:italic>RNAi plants are accompanied by significantly decreased levels of flavonoids and steroidal glycoalkaloids. Thus, altered metabolism in <jats:italic>StSERK3A\/B-<\/jats:italic>RNAi plants correlates with the ability of StSERK3A\/B-depleted plants to mount defense, despite highly decreased early immune responses.<\/jats:p>","DOI":"10.1038\/s41598-019-54944-y","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T14:43:27Z","timestamp":1576507407000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Early Pep-13-induced immune responses are SERK3A\/B-dependent in potato"],"prefix":"10.1038","volume":"9","author":[{"given":"Linda","family":"Nietzschmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Gorzolka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Smolka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Matern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Eschen-Lippold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dierk","family":"Scheel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Rosahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"54944_CR1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.pbi.2012.05.006","volume":"15","author":"J Monaghan","year":"2012","unstructured":"Monaghan, J. & Zipfel, C. 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