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This is a Prospective, cross-sectional study. Thirty high myopia subjects and fifty healthy subjects were enrolled. Healthy and high myopia subjects were imaged with the SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). For each eye, five 12\u2009\u00d7\u200912-mm OCTA volume scans were acquired. The <jats:italic>en face<\/jats:italic> CC images were then exported to imageJ and a semi-automated algorithm was used for subsequent quantitative analysis. The main outcome was a quantitative analysis of the CC. This analysis was performed in three different regions: (i) peripapillary, (ii) macular, and (iii) periphery. In addition, CC variables were further investigated in distinct fields within these three different regions. Thirty myopic eyes (32 subjects; myopic group) and fifty eyes (50 subjects; control group) without elevated myopia were included in the analysis. Mean\u2009\u00b1\u2009SD age was 26.9\u2009\u00b1\u20092.9 years [median: 27 years; range: 20.0\u201340.0 years]. Mean\u2009\u00b1\u2009SD axial length was 26.6\u2009\u00b1\u20090.6\u2009mm [median: 26.2\u2009mm; range: 26.1 to 28.0\u2009mm]. Mean\u2009\u00b1\u2009SD axial length was 26.6\u2009\u00b1\u20090.6\u2009mm [median: 26.2\u2009mm; range: 26.1 to 28.0\u2009mm] in the myopic group and 23.9\u2009\u00b1\u20091.1\u2009mm [median: 23.9\u2009mm; range: 21.8 to 25.9\u2009mm] in the control group. The total signal void area was significantly greater in myopic eyes compared with control group. The peripapillary region exhibited the greatest total signal void area (p\u2009&lt;\u20090.0001 vs macular region, p\u2009&lt;\u20090.0001 vs peripheral region). Within the macular region, the foveal area exhibited a greater total signal void area in comparison with both the parafoveal area (p\u2009&lt;\u20090.0001) and the perifoveal area (p\u2009&lt;\u20090.0001). In conclusion we report quantitative mapping of the choriocapillaris in myopic eyes compared with an age-matched normal control group. The CC perfusion appears to have a wide topographical variation.<\/jats:p>","DOI":"10.1038\/s41598-019-55192-w","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T15:11:38Z","timestamp":1576163498000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["In Vivo Mapping of the Choriocapillaris in High myopia: a Widefield Swept Source Optical Coherence Tomography Angiography"],"prefix":"10.1038","volume":"9","author":[{"given":"Rodolfo","family":"Mastropasqua","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Viggiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-5031","authenticated-orcid":false,"given":"Enrico","family":"Borrelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Evangelista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Libertini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Di Antonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-5184","authenticated-orcid":false,"given":"Lisa","family":"Toto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"key":"55192_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.preteyeres.2018.07.002","volume":"67","author":"Enrico Borrelli","year":"2018","unstructured":"Borrelli, E., Sarraf, D., Freund, K. 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