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And it is difficult for\nclinicians to distinguish them before operation. The aim of our study was to build a\ndifferential diagnosis nomogram based on platelet (PLT) score model and use internal\nvalidation to check the model. The predicting model was constructed by the\nretrospective database that included in 153 patients with HAE (66 cases) or liver\ncancer (87 cases), and all cases was confirmed by clinicopathology and collected\nfrom November 2011 to December 2018. Lasso regression analysis model was used to\nconstruct data dimensionality reduction, elements selection, and building prediction\nmodel based on the 9 PLT-based scores. A multi-factor regression analysis was\nperformed to construct a simplified prediction model, and we added the selected\nPLT-based scores and relevant clinicopathologic features into the nomogram.\nIdentification capability, calibration, and clinical serviceability of the\nsimplified model were evaluated by the Harrell\u2019s concordance index (C-index),\ncalibration plot, receiver operating characteristic curve (ROC), and decision curve.\nAn internal validation was also evaluated by the bootstrap resampling. The\nsimplified model, including in 4 selected factors, was significantly associated with\ndifferential diagnosis of HAE and liver cancer. Predictors of the simplified\ndiagnosis nomogram consisted of the API index, the FIB-4 index, fibro-quotent\n(FibroQ), and fibrosis index constructed by King\u2019s College Hospital (King\u2019s score).\nThe model presented a perfect identification capability, with a high C-index of\n0.929 (0.919 through internal validation), and good calibration. The area under the\ncurve (AUC) values of this simplified prediction nomogram was 0.929, and the result\nof ROC indicated that this nomogram had a good predictive value. Decision curve\nanalysis showed that our differential diagnosis nomogram had clinically\nidentification capability. In conclusion, the differential diagnosis nomogram could\nbe feasibly performed to verify the preoperative individualized diagnosis of HAE and\nliver cancer.<\/jats:p>","DOI":"10.1038\/s41598-019-55563-3","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T06:02:55Z","timestamp":1576648975000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["RETRACTED ARTICLE: The diagnostic nomogram of platelet-based score models for\nhepatic alveolar echinococcosis and atypical liver cancer"],"prefix":"10.1038","volume":"9","author":[{"given":"Qiancheng","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihao","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenliang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengzhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuepeng","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-7448","authenticated-orcid":false,"given":"Jian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4553-4367","authenticated-orcid":false,"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"55563_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.vetpar.2014.03.009","volume":"202","author":"D Carmena","year":"2014","unstructured":"Carmena, D. & Cardona, G. 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Please see the Retraction Notice for more detail: https:\/\/doi.org\/10.1038\/s41598-020-73758-x.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19403"}}