{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:45:46Z","timestamp":1792190746797,"version":"4.4.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to evaluate the effectiveness of preventing mother to child syphilis transmission to improve pregnancy outcomes. We performed a retrospective analysis of municipal databases of mother-to-child syphilis transmission. Pregnant women with syphilis were included. Group specific pregnancy outcomes were analyzed according to treatment. A total of 28 pregnant women were diagnosed with syphilis in 2012; 321 were diagnosed with syphilis in 2018. A prevalence of 0.14% was observed amongst pregnant women in Suzhou city from 2012\u20132018. Primary treatments included benzathine penicillin, ceftriaxone sodium or erythromycin when patients were allergic to Benzathine penicillin. The treatment coverage was 81.57%, and only 52.86% of pregnant women were adequately treated. Adverse pregnant outcomes were higher amongst untreated women. Expanding early screening coverage and promoting treatment were key to improving pregnancy outcomes amongst women with syphilis.<\/jats:p>","DOI":"10.1038\/s41598-019-56095-6","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T11:03:02Z","timestamp":1576839782000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Treatment evaluation to improve preventing mother to child transmission among women with syphilis"],"prefix":"10.1038","volume":"9","author":[{"given":"Tian","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianlan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoju","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"56095_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2471\/BLT.12.107623","volume":"91","author":"GB Gomez","year":"2013","unstructured":"Gomez, G. B. et al. Untreated maternal syphilis and adverse outcomes of pregnancy: a systematic review and meta-analysis. Bull World Health Organ 91, 217 (2013).","journal-title":"Bull World Health Organ"},{"key":"56095_CR2","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1097\/INF.0b013e3181ac8a69","volume":"28","author":"CR Woods","year":"2009","unstructured":"Woods, C. R. Congenital syphilis-persisting pestilence. Pediatr Infect Dis J 28, 536 (2009).","journal-title":"Pediatr Infect Dis J"},{"key":"56095_CR3","first-page":"e211720","volume":"14","author":"EL Korenromp","year":"2019","unstructured":"Korenromp, E. L. et al. Global burden of maternal and congenital syphilis and associated adverse birth outcomes-Estimates for 2016 and progress since 2012. Plos One 14, e211720 (2019).","journal-title":"Plos One"},{"key":"56095_CR4","doi-asserted-by":"publisher","first-page":"e29945","DOI":"10.1136\/bmjopen-2019-029945","volume":"9","author":"OP Saweri","year":"2019","unstructured":"Saweri, O. P. et al. Cost and cost-effectiveness of point-of-care testing and treatment for sexually transmitted and genital infections in pregnancy in low-income and middle-income countries: a systematic review protocol. BMJ Open 9, e29945 (2019).","journal-title":"BMJ Open"},{"key":"56095_CR5","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1055\/s-0036-1593603","volume":"38","author":"H Milanez","year":"2016","unstructured":"Milanez, H. Syphilis in Pregnancy and Congenital Syphilis: Why Can We not yet Face This Problem? Rev Bras Ginecol Obstet 38, 425 (2016).","journal-title":"Rev Bras Ginecol Obstet"},{"key":"56095_CR6","unstructured":"Organization, W. H., (World Health Organization, Geneva, 2016)."},{"key":"56095_CR7","doi-asserted-by":"publisher","first-page":"e87510","DOI":"10.1371\/journal.pone.0087510","volume":"9","author":"JG Kahn","year":"2014","unstructured":"Kahn, J. G. et al. The cost and cost-effectiveness of scaling up screening and treatment of syphilis in pregnancy: a model. Plos One 9, e87510 (2014).","journal-title":"Plos One"},{"key":"56095_CR8","unstructured":"Organization, W. H., Elimination of mother-to-child transmission of HIV and syphilis (second edition) (2017)."},{"key":"56095_CR9","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1136\/sextrans-2015-052363","volume":"92","author":"XH Zhang","year":"2016","unstructured":"Zhang, X. H., Xu, J., Chen, D. Q., Guo, L. F. & Qiu, L. Q. Effectiveness of treatment to improve pregnancy outcomes among women with syphilis in Zhejiang Province, China. Sex Transm Infect 92, 537 (2016).","journal-title":"Sex Transm Infect"},{"key":"56095_CR10","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1136\/sti.2007.025338","volume":"83","author":"A Matteelli","year":"2007","unstructured":"Matteelli, A. et al. Congenital syphilis in Italy. Sex Transm Infect 83, 590 (2007).","journal-title":"Sex Transm Infect"},{"key":"56095_CR11","doi-asserted-by":"publisher","first-page":"e1001396","DOI":"10.1371\/journal.pmed.1001396","volume":"10","author":"L Newman","year":"2013","unstructured":"Newman, L. et al. Global estimates of syphilis in pregnancy and associated adverse outcomes: analysis of multinational antenatal surveillance data. Plos Med 10, e1001396 (2013).","journal-title":"Plos Med"},{"key":"56095_CR12","first-page":"693","volume":"48","author":"N Jiang","year":"2014","unstructured":"Jiang, N., Gong, X. & Yue, X. Estimation of syphilis epidemic through application of workbook method among populations aged from 15 to 49 years old in China in 2011. Zhonghua Yu Fang Yi Xue Za Zhi 48, 693 (2014).","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"56095_CR13","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ijgo.2014.09.017","volume":"128","author":"L Arnesen","year":"2015","unstructured":"Arnesen, L., Martinez, G., Mainero, L., Serruya, S. & Duran, P. Gestational syphilis and stillbirth in Latin America and the Caribbean. Int J Gynaecol Obstet 128, 241 (2015).","journal-title":"Int J Gynaecol Obstet"},{"key":"56095_CR14","first-page":"430","volume":"45","author":"BR Archana","year":"2014","unstructured":"Archana, B. R. et al. Maternal and congenital syphilis in Karnataka, India. Southeast Asian J Trop Med Public Health 45, 430 (2014).","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"56095_CR15","doi-asserted-by":"publisher","first-page":"17073","DOI":"10.1038\/nrdp.2017.73","volume":"3","author":"RW Peeling","year":"2017","unstructured":"Peeling, R. W. et al. Syphilis. Nat Rev Dis Primers 3, 17073 (2017).","journal-title":"Nat Rev Dis Primers"},{"key":"56095_CR16","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1056\/NEJM195110252451702","volume":"245","author":"NJ Fiumara","year":"1951","unstructured":"Fiumara, N. J. Congenital syphilis in Massachusetts. N Engl J Med 245, 634 (1951).","journal-title":"N Engl J Med"},{"key":"56095_CR17","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1086\/342952","volume":"186","author":"D Watson-Jones","year":"2002","unstructured":"Watson-Jones, D. et al. Syphilis in pregnancy in Tanzania. I. Impact of maternal syphilis on outcome of pregnancy. J Infect Dis 186, 940 (2002).","journal-title":"J Infect Dis"},{"key":"56095_CR18","doi-asserted-by":"publisher","first-page":"e102203","DOI":"10.1371\/journal.pone.0102203","volume":"9","author":"J Qin","year":"2014","unstructured":"Qin, J. et al. Reported estimates of adverse pregnancy outcomes among women with and without syphilis: a systematic review and meta-analysis. Plos One 9, e102203 (2014).","journal-title":"Plos One"},{"key":"56095_CR19","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1086\/342951","volume":"186","author":"D Watson-Jones","year":"2002","unstructured":"Watson-Jones, D. et al. Syphilis in pregnancy in Tanzania. II. The effectiveness of antenatal syphilis screening and single-dose benzathine penicillin treatment for the prevention of adverse pregnancy outcomes. J Infect Dis 186, 948 (2002).","journal-title":"J Infect Dis"},{"key":"56095_CR20","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1136\/sti.79.5.375","volume":"79","author":"F Terris-Prestholt","year":"2003","unstructured":"Terris-Prestholt, F. et al. Is antenatal syphilis screening still cost effective in sub-Saharan Africa. SEX TRANSM INFECT 79, 375 (2003).","journal-title":"SEX TRANSM INFECT"},{"key":"56095_CR21","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1177\/0956462415609862","volume":"27","author":"HE Wallace","year":"2016","unstructured":"Wallace, H. E., Isitt, C. E., Broomhall, H. M., Perry, A. E. & Wilson, J. D. Adverse pregnancy outcomes following syphilis treatment in pregnancy in the UK. Int J Std Aids 27, 1108 (2016).","journal-title":"Int J Std Aids"},{"key":"56095_CR22","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1590\/0037-8682-0030-2014","volume":"47","author":"LR Oliveira","year":"2014","unstructured":"Oliveira, L. R. et al. Evaluation of preventative and control measures for congenital syphilis in State of Mato Grosso. Rev Soc Bras Med Trop 47, 334 (2014).","journal-title":"Rev Soc Bras Med Trop"},{"key":"56095_CR23","first-page":"422","volume":"37","author":"L Arnesen","year":"2015","unstructured":"Arnesen, L., Serruya, S. & Duran, P. Gestational syphilis and stillbirth in the Americas: a systematic review and meta-analysis. Rev Panam Salud Publica 37, 422 (2015).","journal-title":"Rev Panam Salud Publica"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-56095-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-56095-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-56095-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T17:41:23Z","timestamp":1671298883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-56095-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,20]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["56095"],"URL":"https:\/\/doi.org\/10.1038\/s41598-019-56095-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,20]]},"assertion":[{"value":"28 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19547"}}