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This biomaterial is a composite recommended for dental and orthopedic grafting surgery, for guided bone regeneration, including maxillary sinus lift, fresh alveolus filling, and treatment of furcation lesions. The nano biomaterials surface area is from 30% to 50% higher than those with micro dimensions. Another advantage is that the alloplastic biomaterial has homogeneous properties due to the complete manufacturing control. The analyzed biomaterial composite was characterized by XRD, cytochemistry, scanning electron microscopy, porosimetry and <jats:italic>in vivo<\/jats:italic> experiments (animals). The results showed that the analyzed biomaterial composite has 78.76% hydroxyapatite [Ca<jats:sub>5<\/jats:sub>(PO<jats:sub>4<\/jats:sub>)<jats:sub>3<\/jats:sub>(OH)] with monoclinic structure, 21.03% \u03b2-tricalcium phosphate [\u03b2 -Ca<jats:sub>3<\/jats:sub>(PO<jats:sub>4<\/jats:sub>)<jats:sub>2<\/jats:sub>] with trigonal structure and 0.19% of CaO with cubic structure, nanoparticles with homogeneous shapes, and nanoporosity. The <jats:italic>in vivo<\/jats:italic> experiments showed that the composite has null cytotoxicity, and the site of insertion biomaterials has a high level of vascularization and bone formation. The conclusion is that the synthetic biomaterial with Blue Bone designation presents characteristics suitable for use in grafting surgery applications.<\/jats:p>","DOI":"10.1038\/s41598-019-56124-4","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T11:03:50Z","timestamp":1576839830000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Nanosized hydroxyapatite and \u03b2-tricalcium phosphate composite: Physico-chemical, cytotoxicity, morphological properties and in vivo trial"],"prefix":"10.1038","volume":"9","author":[{"given":"Igor","family":"da Silva Brum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Jos\u00e9","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Luis","family":"da Silva Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio Alencar","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6592-3971","authenticated-orcid":false,"given":"Luiza Braga Ferreira","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7560-6926","authenticated-orcid":false,"given":"Carlos Nelson","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"56124_CR1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.mser.2007.05.001","volume":"58","author":"MJ Olszta","year":"2007","unstructured":"Olszta, M. 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