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This study introduces a novel method of glaucoma induction that offers researchers round-the-clock measurement and reversible control of IOP for the first time. One eye of Brown-Norway rats was implanted with a cannula tethered to a pressure sensor and aqueous reservoir. IOP was raised 10\u2009mmHg for weeks-to-months in treated animals and unaltered in control animals. Counts of Brn3a-expressing retinal ganglion cells (RGCs) in implanted eyes were indistinguishable from non-implanted eyes in control animals and 15\u2009\u00b1\u20092%, 23\u2009\u00b1\u20094%, and 38\u2009\u00b1\u20094% lower in animals exposed to 2, 4, and 9 weeks of IOP elevation. RGC loss was greater in peripheral retina at 2 weeks and widespread at longer durations. Optic nerves also showed progressive degeneration with exposure duration, yet conventional outflow facility of implanted eyes was normal (24.1\u2009\u00b1\u20092.9\u2009nl\/min\/mmHg) even after 9-weeks elevation. Hence, this infusion-based glaucoma model exhibits graded neural damage with unimpaired outflow pathways. The model further revealed a potentially-significant finding that outflow properties of rat eyes do not remodel in response to chronic ocular hypertension.<\/jats:p>","DOI":"10.1038\/s41598-019-57022-5","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T06:03:47Z","timestamp":1578636227000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Experimental glaucoma model with controllable intraocular pressure history"],"prefix":"10.1038","volume":"10","author":[{"given":"Kayla R.","family":"Ficarrotta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef H.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Passaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"57022_CR1","doi-asserted-by":"publisher","first-page":"692609","DOI":"10.1155\/2012\/692609","volume":"2012","author":"RA Bouhenni","year":"2012","unstructured":"Bouhenni, R. 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