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Although some studies have demonstrated that miR-27b is down-regulated in the oral specimens of patients suffering with oral lichen planus (OLP), the molecular mechanism of miR-27b decrease remains a large mystery, and the expression of miR-27a in OLP is not well explored. Here, we demonstrated both miR-27a and miR-27b, compared with healthy controls, were reduced in the oral biopsies, serum and saliva samples derived from OLP patients. The reductions of miR-27a\/b were also confirmed in the lipopolysaccharide (LPS)- or activated CD4<jats:sup>+<\/jats:sup> T cell-treated human oral keratinocytes (HOKs). Furthermore, we found vitamin D receptor (VDR) binding sites in the promoters of <jats:italic>miR-27a\/b<\/jats:italic> genes and verified this finding. We also tested miR-27a\/b levels in the oral epithelium from paricalcitol-treated, vitamin D deficient or <jats:italic>VDR<\/jats:italic> knockout mice. In the rescue experiments, we confirmed vitamin D and VDR inhibited LPS- or activated CD4<jats:sup>+<\/jats:sup> T cell-induced miR-27a\/b reductions in HOKs. In sum, our results show that vitamin D\/VDR signaling induces miR-27a\/b in oral lichen planus.<\/jats:p>","DOI":"10.1038\/s41598-019-57288-9","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T11:03:00Z","timestamp":1579086180000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Vitamin D\/VDR signaling induces miR-27a\/b expression in oral lichen planus"],"prefix":"10.1038","volume":"10","author":[{"given":"Xuejun","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tivoli","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"57288_CR1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.oraloncology.2008.05.016","volume":"45","author":"I van der Waal","year":"2009","unstructured":"van der Waal, I. 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