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Abnormal hepatic accumulation of fat causes fatty liver or hepatic steatosis, and long-term consumption of a high-fat diet is known to be a key obesity-causing factor. Recent studies have demonstrated that probiotics such as <jats:italic>Lactobacillus strains<\/jats:italic>, exert an anti-obesity effect by regulating adipogenesis. However, it is still unknown how the consumption of probiotics can reduce abdominal fat volume by regulating the hepatic expression of lipogenic genes. Therefore, we evaluated the effect of long-term ingestion of <jats:italic>L<\/jats:italic>. <jats:italic>plantarum<\/jats:italic> LMT1-48 on the expression of lipogenic genes in high-fat diet (HFD)-fed mice. We observed that treatment of 3T3-L1 adipocytes with <jats:italic>L<\/jats:italic>. <jats:italic>plantarum<\/jats:italic> LMT1-48 extract inhibited their differentiation and lipid accumulation by downregulating lipogenic genes, namely, <jats:italic>PPAR\u03b3<\/jats:italic>, <jats:italic>C\/EBP\u03b1<\/jats:italic>, <jats:italic>FAS<\/jats:italic>, and <jats:italic>FABP4<\/jats:italic>. Interestingly, administration of <jats:italic>L<\/jats:italic>. <jats:italic>plantarum<\/jats:italic> LMT1-48 reduced liver weight and liver triglycerides concurrently with the downregulation of the lipogenic genes <jats:italic>PPAR\u03b3<\/jats:italic>, <jats:italic>HSL<\/jats:italic>, <jats:italic>SCD-1<\/jats:italic>, and <jats:italic>FAT\/CD36<\/jats:italic> in the liver, resulting in the reduction of body weight and fat volume in HFD-fed obese mice. Notably, we also observed that the administration of at least 10<jats:sup>6<\/jats:sup> CFU of <jats:italic>L<\/jats:italic>. <jats:italic>plantarum<\/jats:italic> LMT1-48 significantly lowered body weight and abdominal fat volume in modified diet-fed mouse models. Collectively, these data suggest that <jats:italic>L<\/jats:italic>. <jats:italic>plantarum<\/jats:italic> LMT1-48 is a potential healthy food for obese people.<\/jats:p>","DOI":"10.1038\/s41598-020-57615-5","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T11:02:51Z","timestamp":1579604571000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Lactobacillus plantarum LMT1-48 exerts anti-obesity effect in high-fat diet-induced obese mice by regulating expression of lipogenic genes"],"prefix":"10.1038","volume":"10","author":[{"given":"Woo Jin","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Uk","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Min","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Ri","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ho","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6171-6956","authenticated-orcid":false,"given":"Yeung-Hyen","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"57615_CR1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/35007508","volume":"404","author":"PG Kopelman","year":"2000","unstructured":"Kopelman, P. 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