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This study aimed to identify the incidence and predictive factors of moderate-severe postoperative pain within 48\u2009hours following video-assisted thoracoscopic surgery (VATS) in a tertiary hospital. A retrospective cohort analysis was performed using medical records of adult patients who underwent VATS between January 2015 and December 2016. Logistic regression was performed to identify predictive factors for moderate-severe pain (visual analogue scale, VAS\u2009\u2265\u20094) within 24\u2009hours and within 48\u2009hours postoperatively. Of the 1164 participants, the incidence of moderate-severe pain was 12.7% within the first 24\u2009hours and 15.6% within the first 48\u2009hours after surgery. In multivariable analysis, the independent risk factors related to moderate-severe pain within 24\u2009hours after surgery were younger age, increased body mass index, preoperative pain within 1 month and history of smoking. The risk factors for moderate-severe acute pain within 48\u2009hours were almost the same, except that the number of chest tubes were also included. Moderate-severe postoperative pain following VATS is not rare, and presence of several risk factors deserves more aggressive pain management strategies perioperatively.<\/jats:p>","DOI":"10.1038\/s41598-020-57620-8","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T06:04:29Z","timestamp":1579586669000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Moderate-severe postoperative pain in patients undergoing video-assisted thoracoscopic surgery: A retrospective study"],"prefix":"10.1038","volume":"10","author":[{"given":"Kai","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"57620_CR1","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1213\/01.ANE.0000068822.10113.9E","volume":"97","author":"JL Apfelbaum","year":"2003","unstructured":"Apfelbaum, J. 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