{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:54:39Z","timestamp":1792626879248,"version":"4.5.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["UNCE\/MED\/006"],"award-info":[{"award-number":["UNCE\/MED\/006"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["National Sustainability Program I (NPU I) Nr. LO1503"],"award-info":[{"award-number":["National Sustainability Program I (NPU I) Nr. LO1503"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anastomotic leakage is a severe complication in gastrointestinal surgery. It is often a reason for reoperation together with intestinal passage blockage due to formation of peritoneal adhesions. Different materials as local prevention of these complications have been studied, none of which are nowadays routinely used in clinical practice. Nanofabrics created proved to promote healing with their structure similar to extracellular matrix. We decided to study their impact on anastomotic healing and formation of peritoneal adhesions. We performed an experiment on 24 piglets. We constructed 3 hand sutured end-to-end anastomoses on the small intestine of each pig. We covered the anastomoses with a sheet of polycaprolactone nanomaterial in the first experimental group, with a sheet of copolymer of polylactic acid with polycaprolactone in the second one and no fortifying material was used in the Control group. The animals were sacrificed after 3 weeks of observation. Clinical, biochemical and macroscopic signs of anastomotic leakage or intestinal obstruction were monitored, the quality of the scar tissue was assessed histologically, and a newly developed scoring system was employed to evaluate the presence of adhesions. The material is easy to manipulate with. There was no mortality or major morbidity in our groups. No statistical difference was found inbetween the groups in the matter of level of peritoneal adhesions or the quality of the anastomoses. We created a new adhesion scoring system. The material appears to be safe however needs to be studied further to prove its\u02b9 positive effects.<\/jats:p>","DOI":"10.1038\/s41598-020-58113-4","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T11:03:17Z","timestamp":1579863797000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Experimental fortification of intestinal anastomoses with nanofibrous materials in a large animal model"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2125-0685","authenticated-orcid":false,"given":"Jachym","family":"Rosendorf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Horakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marketa","family":"Klicova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Palek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Cervenkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Kural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-4770","authenticated-orcid":false,"given":"Petr","family":"Hosek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Kriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaclav","family":"Tegl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimira","family":"Moulisova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbynek","family":"Tonar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav","family":"Treska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaclav","family":"Liska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"issue":"2","key":"58113_CR1","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/00000658-198708000-00004","volume":"206","author":"R. KENT JEX","year":"1987","unstructured":"Jex, R. K., van Heerden, J. A., Wolff, B. G., Ready, R. L., Ilstrup, D. M. Gastrointestinal Anastomoses Factors Affecting Early Complications, Ann. Surg. Aug, 206(2), 138\u201341 (1987).","journal-title":"Annals of Surgery"},{"issue":"2","key":"58113_CR2","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1097\/01.sla.0000225083.27182.85","volume":"245","author":"N Hyman","year":"2007","unstructured":"Hyman, N., Manchester, T. L., Osler, T., Burns, B. & Cataldo, P. A. Anastomotic Leaks After Intestinal Anastomosis It\u2019s Later Than You Think. Ann. Surg. Feb 245(2), 254\u20138 (2007).","journal-title":"Ann. Surg. Feb"},{"issue":"5-6","key":"58113_CR3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1159\/000096648","volume":"23","author":"LS Yo","year":"2006","unstructured":"Yo, L. S., Consten, E. C., Quarles van Ufford, H. M., Gooszen, H. G. & Gagner, M. Buttressing of the staple line in gastrointestinal anastomoses: overview of new technology designed to reduce perioperative complications. Dig. Surg. 23(5-6), 283\u201391 (2006).","journal-title":"Dig. Surg."},{"issue":"33","key":"58113_CR4","doi-asserted-by":"publisher","first-page":"6172","DOI":"10.3748\/wjg.v23.i33.6172","volume":"23","author":"SJ van Rooijen","year":"2017","unstructured":"van Rooijen, S. J. et al. Definition of colorectal anastomotic leakage: A consensus survey among Dutch and Chinese colorectal surgeons. World J. Gastroenterol. 23(33), 6172\u20136180 (2017).","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"58113_CR5","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1001\/2013.jamasurg.33","volume":"148","author":"JC Slieker","year":"2013","unstructured":"Slieker, J. C., Daams, F., Mulder, I. M., Jeekel, J. & Lange, J. F. Systematic review of the technique of colorectal anastomosis. JAMA Surg. 148(2), 190\u2013201 (2013).","journal-title":"JAMA Surg."},{"issue":"4","key":"58113_CR6","first-page":"364","volume":"184","author":"R Golub","year":"1997","unstructured":"Golub, R., Golub, R. W., Cantu, R. Jr. & Stein, H. D. A multivariate analysis of factors contributing to leakage of intestinal anastomoses. J. Am. Coll. Surg. 184(4), 364\u201372 (1997).","journal-title":"J. Am. Coll. Surg."},{"issue":"9","key":"58113_CR7","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1111\/codi.12618","volume":"16","author":"HC Pommergaard","year":"2014","unstructured":"Pommergaard, H. C. et al. Preoperative risk factors for anastomotic leakage after resection for colorectal cancer: a systematic review and meta-analysis. Colorectal Dis. 16(9), 662\u201371 (2014).","journal-title":"Colorectal Dis."},{"key":"58113_CR8","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s00384-016-2573-y","volume":"31","author":"GSA Boersema","year":"2016","unstructured":"Boersema, G. S. A. et al. Hyperbaric oxygen therapy improves colorectal anastomotic healing. Int. J. Colorectal Dis. 31, 1031\u20131038 (2016).","journal-title":"Int. J. Colorectal Dis."},{"issue":"8","key":"58113_CR9","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1590\/s0102-865020170080000004","volume":"32","author":"HR Khorshidi","year":"2017","unstructured":"Khorshidi, H. R. et al. Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study. Acta Cir. Bras. 32(8), 626\u2013632 (2017).","journal-title":"Acta Cir. Bras."},{"issue":"6","key":"58113_CR10","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1080\/08941930701772173","volume":"20","author":"T Nordentoft","year":"2007","unstructured":"Nordentoft, T., R\u00f8mer, J. & S\u00f8rensen, M. Sealing of gastrointestinal anastomoses with a fibrin glue-coated collagen patch: a safety study. J. Invest. Surg. 20(6), 363\u20139 (2007).","journal-title":"J. Invest. Surg."},{"key":"58113_CR11","doi-asserted-by":"crossref","unstructured":"Nordentoft, T. & Holte, K. Preventing Clinical Leakage of Colonic Anastomoses with A Fibrin - Coated Collagen Patch Sealing - An Experimental Study. Arch Clin Exp Surg. 3(4), 201\u2013206.","DOI":"10.5455\/aces.20130321071651"},{"issue":"3","key":"58113_CR12","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1308\/rcsann.2018.0003","volume":"100","author":"J Trotter","year":"2014","unstructured":"Trotter, J. et al. (2018) The use of a novel adhesive tissue patch as an aid to anastomotic healing. Ann. R. Coll. Surg. Engl. 100(3), 230\u2013234 (2014).","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"58113_CR13","first-page":"16","volume":"23","author":"MI Aznan","year":"2016","unstructured":"Aznan, M. I. et al. Effect of Tualang honey on the anastomotic wound healing in large bowel anastomosis in rats-A randomized controlled trial. BMC Complement. Altern. Med. 23, 16\u201328 (2016).","journal-title":"BMC Complement. Altern. Med."},{"issue":"11","key":"58113_CR14","first-page":"1620","volume":"18","author":"G Bonanomi","year":"2004","unstructured":"Bonanomi, G., Prince, J. M., McSteen, F., Schauer, P. R. & Hamad, G. G. Sealing effect of fibrin glue on the healing of gastrointestinal anastomoses: implications for the endoscopic treatment of leaks. Surg. Endosc. 18(11), 1620\u20134 (2004).","journal-title":"Surg. Endosc."},{"issue":"3","key":"58113_CR15","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1177\/1553350611429025","volume":"19","author":"DA Fajardo","year":"2012","unstructured":"Fajardo, D. A., Amador-Ortiz, C., Chun, J., Stewart, D. & Fleshman, J. W. Evaluation of Bioabsorbable Seamguard for Staple Line Reinforcement in Stapled Rectal Anastomoses. Surg. Innov. 19(3), 288\u201394 (2012).","journal-title":"Surg. Innov."},{"key":"58113_CR16","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jss.2017.05.001","volume":"217","author":"GSA Boersema","year":"2017","unstructured":"Boersema, G. S. A. et al. Reinforcement of the colon anastomosis with cyanoacrylate glue: a porcine model. J. Surg. Res. 217, 84\u201391 (2017).","journal-title":"J. Surg. Res."},{"issue":"17","key":"58113_CR17","first-page":"2275","volume":"17","author":"G Adas","year":"2013","unstructured":"Adas, G. et al. Treatment of ischemic colonic anastomoses with systemic transplanted bone marrow derived mesenchymal stem cells. Eur. Rev. Med. Pharmacol. Sci. 17(17), 2275\u201385 (2013).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"2","key":"58113_CR18","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/codi.12411","volume":"16","author":"NA Hirst","year":"2014","unstructured":"Hirst, N. A. et al. Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery. Colorectal Dis. 16(2), 95\u2013109 (2014).","journal-title":"Colorectal Dis."},{"issue":"8","key":"58113_CR19","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1001\/archsurg.1988.01400320054011","volume":"123","author":"WJ Mileski","year":"1988","unstructured":"Mileski, W. J., Joehl, R. J., Rege, R. V. & Nahrwold, D. L. Treatment of anastomotic leakage following low anterior colon resection. Arch. Surg. 123(8), 968\u201371 (1988).","journal-title":"Arch. Surg."},{"issue":"9","key":"58113_CR20","doi-asserted-by":"publisher","first-page":"621","DOI":"10.4240\/wjgs.v8.i9.621","volume":"8","author":"Y Sevim","year":"2016","unstructured":"Sevim, Y., Celik, S. U., Yavarifar, H. & Akyol, C. Minimally invasive management of anastomotic leaks in colorectal surgery. World J. Gastrointest. Surg. 27 8(9), 621\u2013626 (2016).","journal-title":"World J. Gastrointest. Surg. 27"},{"issue":"12","key":"58113_CR21","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1007\/s11605-016-3255-3","volume":"20","author":"SA Chadi","year":"2016","unstructured":"Chadi, S. A. et al. Emerging Trends in the Etiology, Prevention, and Treatment of Gastrointestinal Anastomotic Leakage. J. Gastrointest. Surg. 20(12), 2035\u20132051 (2016).","journal-title":"J. Gastrointest. Surg."},{"issue":"2","key":"58113_CR22","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1055\/s-0036-1580630","volume":"29","author":"MS Thomas","year":"2016","unstructured":"Thomas, M. S. & Margolin, D. A. Management of Colorectal Anastomotic Leak. Clin. Colon. Rectal Surg. 29(2), 138\u201344 (2016).","journal-title":"Clin. Colon. Rectal Surg."},{"issue":"12","key":"58113_CR23","doi-asserted-by":"publisher","first-page":"378","DOI":"10.4240\/wjgs.v7.i12.378","volume":"7","author":"J Blumetti","year":"2015","unstructured":"Blumetti, J. & Abcarian, H. Management of low colorectal anastomotic leak: Preserving the anastomosis. World J. Gastrointest. Surg. 27 7(12), 378\u201383 (2015).","journal-title":"World J. Gastrointest. Surg. 27"},{"issue":"4","key":"58113_CR24","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00384-016-2744-x","volume":"32","author":"B Gessler","year":"2017","unstructured":"Gessler, B., Eriksson, O. & Angenete, E. Diagnosis, treatment, and consequences of anastomotic leakage in colorectal surgery. Int. J. Colorectal Dis. 32(4), 549\u2013556 (2017).","journal-title":"Int. J. Colorectal Dis."},{"issue":"1","key":"58113_CR25","first-page":"25","volume":"83","author":"P Paliogiannis","year":"2012","unstructured":"Paliogiannis, P. et al. Conservative management of minor anastomotic leakage after open elective colorectal surgery. Ann. Ital. Chir. 83(1), 25\u20138 (2012).","journal-title":"Ann. Ital. Chir."},{"issue":"12","key":"58113_CR26","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1016\/j.jpedsurg.2011.09.011","volume":"46","author":"R Zhao","year":"2011","unstructured":"Zhao, R., Li, K., Shen, C. & Zheng, S. The outcome of conservative treatment for anastomotic leakage after surgical repair of esophageal atresia. J. Pediatr. Surg. 46(12), 2274\u20138 (2011).","journal-title":"J. Pediatr. Surg."},{"issue":"7","key":"58113_CR27","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1067\/j.cpsurg.2015.05.001","volume":"52","author":"RT Beyene","year":"2015","unstructured":"Beyene, R. T., Kavalukas, S. L. & Barbul, A. Intra-abdominal adhesions. Anatomy, physiology, pathophysiology, and treatment. Curr. Probl. Surg. 52(7), 271\u2013319 (2015).","journal-title":"Curr. Probl. Surg."},{"issue":"6","key":"58113_CR28","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1093\/humupd\/7.6.567","volume":"7","author":"MP Diamond","year":"2001","unstructured":"Diamond, M. P. & Freeman, M. L. Clinical implications of postsurgical adhesions. Hum. Reprod. Update. 7(6), 567\u201376 (2001).","journal-title":"Hum. Reprod. Update."},{"issue":"Suppl 2","key":"58113_CR29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1463-1318.2007.01358.x","volume":"9","author":"H van Goor","year":"2007","unstructured":"van Goor, H. Consequences and complications of peritoneal adhesions. Colorectal Dis. 9(Suppl 2), 25\u201334 (2007).","journal-title":"Colorectal Dis."},{"key":"58113_CR30","first-page":"5","volume":"577","author":"H Ellis","year":"1997","unstructured":"Ellis, H. The clinical significance of adhesions: focus on intestinal obstruction. Eur. J. Surg. Suppl. 577, 5\u20139 (1997).","journal-title":"Eur. J. Surg. Suppl."},{"issue":"4","key":"58113_CR31","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000337741","volume":"48","author":"M Ditzel","year":"2012","unstructured":"Ditzel, M. et al. Postoperative adhesion prevention with a new barrier: an experimental study. Eur. Surg. Res. 48(4), 187\u201393 (2012).","journal-title":"Eur. Surg. Res."},{"issue":"1","key":"58113_CR32","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1749-7922-8-6","volume":"8","author":"Federico Coccolini","year":"2013","unstructured":"Coccolini, F. et al. Peritoneal adhesion index (PAI): proposal of a score for the \u201cignored iceberg\u201d of medicine and surgery. World J. Emerg. Surg. 31;8(1):6 (2013).","journal-title":"World Journal of Emergency Surgery"},{"key":"58113_CR33","first-page":"1009","volume":"1990","author":"HV Z\u00fchlke","year":"1990","unstructured":"Z\u00fchlke, H. V., Lorenz, E. M., Straub, E. M. & Savvas, V. Pathophysiology and classification of adhesions. Langenbecks Arch. Chir. Suppl. II Verh. Dtsch. Ges. Chir. 1990, 1009\u201316 (1990).","journal-title":"Langenbecks Arch. Chir. Suppl. II Verh. Dtsch. Ges. Chir."},{"issue":"6","key":"58113_CR34","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1001\/archsurg.1974.01350300081019","volume":"108","author":"SK Nair","year":"1974","unstructured":"Nair, S. K., Bhat, I. K. & Aurora, A. L. Role of proteolytic enzyme in the prevention of postoperative intraperitoneal adhesions. Arch Surg. 108(6), 849\u201353 (1974).","journal-title":"Arch Surg."},{"issue":"3","key":"58113_CR35","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1007\/s10856-007-3218-z","volume":"19","author":"S Srouji","year":"2008","unstructured":"Srouji, S., Kizhner, T., Suss-Tobi, E., Livne, E. & Zussman, E. 3-D Nanofibrous electrospun multilayered construct is an alternative ECM mimicking scaffold. J. Mater. Sci. Mater Med. 19(3), 1249\u201355 (2008).","journal-title":"J. Mater. Sci. Mater Med."},{"key":"58113_CR36","first-page":"1","volume":"1","author":"M Yu","year":"2017","unstructured":"Yu, M. et al. Recent advances in needleless electrospinning of ultrathin fibers: From academia to industrial production. Marcomol. Mater. Eng. 1, 1\u201319 (2017).","journal-title":"Marcomol. Mater. Eng."},{"issue":"48","key":"58113_CR37","doi-asserted-by":"publisher","first-page":"26816","DOI":"10.1039\/C4CP04346D","volume":"16","author":"P Pokorny","year":"2014","unstructured":"Pokorny, P. et al. Effective AC needleless and collectorless electrospinning for yarn production. Phys. Chem. Chem Phys. 16(48), 26816\u201322 (2014).","journal-title":"Phys. Chem. Chem Phys."},{"issue":"5","key":"58113_CR38","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1089\/ten.teb.2011.0238","volume":"17","author":"RL Dahlin","year":"2011","unstructured":"Dahlin, R. L., Kasper, F. K. & Mikos, A. G. Polymeric nanofibers in tissue engineering. Tissue Eng. Part. B Rev. 17(5), 349\u201364 (2011).","journal-title":"Tissue Eng. Part. B Rev."},{"key":"58113_CR39","first-page":"234","volume":"4","author":"S Krchova","year":"2014","unstructured":"Krchova, S. et al. Nanofibers for the wound healing. Czech Dermatology. 4, 234\u2013240 (2014).","journal-title":"Czech Dermatology."},{"key":"58113_CR40","first-page":"1","volume":"45","author":"I Yalcin","year":"2014","unstructured":"Yalcin, I. et al. Design of polycaprolactone vascular grafts. J. Ind. Text. 45, 1\u201321 (2014).","journal-title":"J. Ind. Text."},{"issue":"92","key":"58113_CR41","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.msec.2018.06.041","volume":"1","author":"J Horakova","year":"2018","unstructured":"Horakova, J. et al. The effect of ethylene oxide sterilization on electrospun vascular grafts made from biodegradable polyesters. Mater. Sci. Eng. C. Mater Biol. Appl. 1(92), 132\u2013142 (2018).","journal-title":"Mater. Sci. Eng. C. Mater Biol. Appl."},{"key":"58113_CR42","doi-asserted-by":"crossref","unstructured":"Williams, D. L. & Browder, I. W. Murine models of intestinal anastomoses. In: DiPietro, L. A. & Burns, A. L., (ed) Wound healing: Methods and protocols., vol. 10, 1st ed. New Jersey: Humana Press Inc., pp 133\u2013140 (2010).","DOI":"10.1385\/1-59259-332-1:133"},{"key":"58113_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.22203\/eCM.v005a01","volume":"5","author":"PA Gunatillake","year":"2003","unstructured":"Gunatillake, P. A. & Adhikari, R. Biodegradable synthetic polymers for tissue engineering. Eur. Cell Mater. 5, 1\u201316 (2003).","journal-title":"Eur. Cell Mater."},{"issue":"1","key":"58113_CR44","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/110241599750007522","volume":"165","author":"TL Zilling","year":"1999","unstructured":"Zilling, T. L., Jansson, O., Walther, B. S. & Ottosson, A. Sutureless small bowel anastomoses: experimental study in pigs. Eur. J. Surg. 165(1), 61\u20138 (1999).","journal-title":"Eur. J. Surg."},{"key":"58113_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/srep39936","volume":"7","author":"YW Li","year":"2017","unstructured":"Li, Y. W. et al. Very Early Colorectal Anastomotic Leakage within 5 Post-operative Days: a More Severe Subtype Needs Relaparatomy. Sci. Rep. 7, 39936 (2017).","journal-title":"Sci. Rep."},{"key":"58113_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-11-6","volume":"11","author":"C Kosmidis","year":"2011","unstructured":"Kosmidis, C. et al. Myofibroblasts and colonic anastomosis healing in Wistar rats. BMC Surg. 11, 6 (2011).","journal-title":"BMC Surg."},{"key":"58113_CR47","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000096975","volume":"39","author":"T Nordentoft","year":"2007","unstructured":"Nordentoft, T. & S\u00f8rensen, M. Leakage of Colon Anastomoses: Development of an Experimental Model in Pigs. Eur. Surg. Res. 39, 14\u201316 (2007).","journal-title":"Eur. Surg. Res."},{"issue":"1-2","key":"58113_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000366418","volume":"54","author":"T Nordentoft","year":"2015","unstructured":"Nordentoft, T., Pommergaard, H. C., Rosenberg, J. & Achiam, M. P. Fibrin glue does not improve healing of gastrointestinal anastomoses: a systematic review. Eur. Surg. Res. 54(1-2), 1\u201313 (2015).","journal-title":"Eur. Surg. Res."},{"key":"58113_CR49","doi-asserted-by":"crossref","unstructured":"Gao, X. et al. Novel thermosensitive hydrogel for preventing formation of abdominal adhesions. 8, 2453\u201363 (2013).","DOI":"10.2147\/IJN.S46357"},{"key":"58113_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejogrb.2014.07.004","volume":"181","author":"EK Caglayan","year":"2014","unstructured":"Caglayan, E. K., Caglayan, K., Erdogan, N., Cinar, H. & G\u00fcng\u00f6r, B. Preventing intraperitoneal adhesions with ethyl pyruvate and hyaluronic acid\/carboxymethylcellulose: a comparative study in an experimental model. Eur. J. Obstet. Gynecol. Reprod. Biol. 181, 1\u20135 (2014).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"6","key":"58113_CR51","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s12262-016-1522-x","volume":"79","author":"H Kataria","year":"2017","unstructured":"Kataria, H. & Singh, V. P. Liquid Paraffin vs Hyaluronic Acid in Preventing Intraperitoneal Adhesions. Indian. J. Surg. 79(6), 539\u2013543 (2017).","journal-title":"Indian. J. Surg."},{"issue":"41","key":"58113_CR52","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.3748\/wjg.v17.i41.4545","volume":"17","author":"W Arung","year":"2011","unstructured":"Arung, W., Meurisse, M. & Detry, O. Pathophysiology and prevention of postoperative peritoneal adhesions. World J. Gastroenterol. 17(41), 4545\u20134553 (2011).","journal-title":"World J. Gastroenterol."},{"issue":"12","key":"58113_CR53","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/BF00311697","volume":"25","author":"GD Tebala","year":"1995","unstructured":"Tebala, G. D., Ceriati, F., Ceriati, E., Vecchioli, A. & Nori, S. The use of cyanoacrylate tissue adhesive in high-risk intestinal anastomoses. Surg. Today. 25(12), 1069\u201372 (1995).","journal-title":"Surg. Today."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-58113-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-58113-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-58113-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T06:24:00Z","timestamp":1670307840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-58113-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,24]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["58113"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-58113-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,24]]},"assertion":[{"value":"31 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors certify they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject of matter or materials in this manuscript.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1134"}}