{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:50:56Z","timestamp":1790661056036,"version":"4.1.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["07127068"],"award-info":[{"award-number":["07127068"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>FRMD6, a member of the group of FERM-domain proteins, is involved both in communication between cells, interactions with extracellular matrix, cellular apoptotic and regenerative mechanisms. FRMD6 was first discovered in the rodent sciatic nerve, and in the present immunohistochemical study we investigated the distribution of FRMD6 in the dorsal root ganglia (DRGs), sciatic nerve and spinal cord following sciatic nerve injury. FRMD6-immunoreactivity was found in the cytoplasm, nucleus or both, and in a majority of DRG neurons. FRMD6-immunoreactivity co-existed with several well-known neuronal markers, including calcitonin gene-related peptide, isolectin B4 and neurofilament 200 in mouse DRGs. After peripheral nerve injury, the FRMD6 mRNA levels and the overall percentage of FRMD6-positive neuron profiles (NPs) were decreased in\u00a0ipsilateral lumbar DRGs, the latter mainly affecting small size neurons with cytoplasmic localization. Conversely, the proportion of NPs with nuclear FRMD6-immunoreactivity was significantly increased. In the sciatic nerve, FRMD6-immunoreactivity was observed in non-neuronal cells and in axons, and accumulated proximally to a ligation of the nerve. In the spinal cord FRMD6-immunoreactivity was detected in neurons in both dorsal and ventral horns, and was upregulated in ipsilateral dorsal horn after peripheral nerve axotomy. Our results demonstrate\u00a0that FRMD6 is strictly regulated by peripheral nerve injury at\u00a0the spinal level.<\/jats:p>","DOI":"10.1038\/s41598-020-58261-7","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T06:03:18Z","timestamp":1580882598000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9885-4159","authenticated-orcid":false,"given":"Chuang","family":"Lyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong-Wei","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Mulder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4858-8056","authenticated-orcid":false,"given":"Mathias","family":"Uhl\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Hui","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"H\u00f6kfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie-Jun","family":"Sten Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"58261_CR1","doi-asserted-by":"publisher","first-page":"5089","DOI":"10.1016\/j.febslet.2005.07.097","volume":"579","author":"FJ Gunn-Moore","year":"2005","unstructured":"Gunn-Moore, F. J. et al. A novel 4.1 ezrin radixin moesin (FERM)-containing protein, \u2018Willin\u2019. FEBS letters 579, 5089\u20135094, https:\/\/doi.org\/10.1016\/j.febslet.2005.07.097 (2005).","journal-title":"FEBS letters"},{"key":"58261_CR2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ynpai.2018.04.001","volume":"4","author":"S Uttam","year":"2018","unstructured":"Uttam, S. et al. Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain. Neurobiology of pain 4, 35\u201344, https:\/\/doi.org\/10.1016\/j.ynpai.2018.04.001 (2018).","journal-title":"Neurobiology of pain"},{"key":"58261_CR3","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1242\/dev.118.4.1291","volume":"118","author":"M Boedigheimer","year":"1993","unstructured":"Boedigheimer, M. & Laughon, A. Expanded: a gene involved in the control of cell proliferation in imaginal discs. Development 118, 1291\u20131301 (1993).","journal-title":"Development"},{"key":"58261_CR4","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1038\/onc.2011.318","volume":"31","author":"S Visser-Grieve","year":"2012","unstructured":"Visser-Grieve, S., Hao, Y. & Yang, X. Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway. Oncogene 31, 1189\u20131195, https:\/\/doi.org\/10.1038\/onc.2011.318 (2012).","journal-title":"Oncogene"},{"key":"58261_CR5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/nrd4161","volume":"13","author":"R Johnson","year":"2014","unstructured":"Johnson, R. & Halder, G. The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nature reviews. Drug discovery 13, 63\u201379, https:\/\/doi.org\/10.1038\/nrd4161 (2014).","journal-title":"Nature reviews. Drug discovery"},{"issue":"9","key":"58261_CR6","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.tcb.2015.05.002","volume":"25","author":"Carsten Gram Hansen","year":"2015","unstructured":"Hansen, C. G., Moroishi, T. & Guan, K. L. YAP and TAZ: a nexus for Hippo signaling and beyond. Trends in cell biology, https:\/\/doi.org\/10.1016\/j.tcb.2015.05.002 (2015).","journal-title":"Trends in Cell Biology"},{"key":"58261_CR7","doi-asserted-by":"publisher","first-page":"e2546","DOI":"10.1038\/cddis.2016.478","volume":"8","author":"X Mao","year":"2017","unstructured":"Mao, X. et al. CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells. Cell death & disease 8, e2546, https:\/\/doi.org\/10.1038\/cddis.2016.478 (2017).","journal-title":"Cell death & disease"},{"key":"58261_CR8","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/onc.2011.224","volume":"31","author":"L Angus","year":"2012","unstructured":"Angus, L. et al. Willin\/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP. Oncogene 31, 238\u2013250, https:\/\/doi.org\/10.1038\/onc.2011.224 (2012).","journal-title":"Oncogene"},{"key":"58261_CR9","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","volume":"19","author":"D Pan","year":"2010","unstructured":"Pan, D. The hippo signaling pathway in development and cancer. Developmental cell 19, 491\u2013505, https:\/\/doi.org\/10.1016\/j.devcel.2010.09.011 (2010).","journal-title":"Developmental cell"},{"key":"58261_CR10","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.tcb.2010.04.005","volume":"20","author":"H Oh","year":"2010","unstructured":"Oh, H. & Irvine, K. D. Yorkie: the final destination of Hippo signaling. Trends in cell biology 20, 410\u2013417, https:\/\/doi.org\/10.1016\/j.tcb.2010.04.005 (2010).","journal-title":"Trends in cell biology"},{"key":"58261_CR11","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1242\/dev.102376","volume":"141","author":"X Varelas","year":"2014","unstructured":"Varelas, X. The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development 141, 1614\u20131626, https:\/\/doi.org\/10.1242\/dev.102376 (2014).","journal-title":"Development"},{"key":"58261_CR12","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1002\/hed.20435","volume":"28","author":"R Madan","year":"2006","unstructured":"Madan, R. et al. Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic signficance for head and neck squamous cell carcinoma. Head & neck 28, 1018\u20131027, https:\/\/doi.org\/10.1002\/hed.20435 (2006).","journal-title":"Head & neck"},{"key":"58261_CR13","doi-asserted-by":"publisher","first-page":"e60028","DOI":"10.1371\/journal.pone.0060028","volume":"8","author":"S Moleirinho","year":"2013","unstructured":"Moleirinho, S. et al. Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts. PloS one 8, e60028, https:\/\/doi.org\/10.1371\/journal.pone.0060028 (2013).","journal-title":"PloS one"},{"key":"58261_CR14","doi-asserted-by":"publisher","first-page":"16084","DOI":"10.18632\/oncotarget.14306","volume":"8","author":"JS Bae","year":"2017","unstructured":"Bae, J. S., Kim, S. M. & Lee, H. The Hippo signaling pathway provides novel anti-cancer drug targets. Oncotarget 8, 16084\u201316098, https:\/\/doi.org\/10.18632\/oncotarget.14306 (2017).","journal-title":"Oncotarget"},{"issue":"11","key":"58261_CR15","doi-asserted-by":"publisher","first-page":"12409","DOI":"10.1096\/fj.201900965R","volume":"33","author":"Susu Mao","year":"2019","unstructured":"Mao, S. et al. A Schwann cell-enriched circular RNA circ-Ankib1 regulates Schwann cell proliferation following peripheral nerve injury. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, fj201900965R, https:\/\/doi.org\/10.1096\/fj.201900965R (2019).","journal-title":"The FASEB Journal"},{"key":"58261_CR16","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cell.2010.08.039","volume":"143","author":"S Parrinello","year":"2010","unstructured":"Parrinello, S. et al. EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting. Cell 143, 145\u2013155, https:\/\/doi.org\/10.1016\/j.cell.2010.08.039 (2010).","journal-title":"Cell"},{"key":"58261_CR17","doi-asserted-by":"publisher","first-page":"e0128951","DOI":"10.1371\/journal.pone.0128951","volume":"10","author":"C Flegel","year":"2015","unstructured":"Flegel, C. et al. RNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on Chemoreceptors. PloS one 10, e0128951, https:\/\/doi.org\/10.1371\/journal.pone.0128951 (2015).","journal-title":"PloS one"},{"key":"58261_CR18","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn.3881","volume":"18","author":"D Usoskin","year":"2015","unstructured":"Usoskin, D. et al. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nature neuroscience 18, 145\u2013153, https:\/\/doi.org\/10.1038\/nn.3881 (2015).","journal-title":"Nature neuroscience"},{"key":"58261_CR19","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.ydbio.2014.11.017","volume":"398","author":"Y Serinagaoglu","year":"2015","unstructured":"Serinagaoglu, Y., Pare, J., Giovannini, M. & Cao, X. Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Developmental biology 398, 97\u2013109, https:\/\/doi.org\/10.1016\/j.ydbio.2014.11.017 (2015).","journal-title":"Developmental biology"},{"key":"58261_CR20","doi-asserted-by":"publisher","first-page":"70080","DOI":"10.18632\/oncotarget.12148","volume":"7","author":"Y Xu","year":"2016","unstructured":"Xu, Y., Wang, K. & Yu, Q. FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases. Oncotarget 7, 70080\u201370091, https:\/\/doi.org\/10.18632\/oncotarget.12148 (2016).","journal-title":"Oncotarget"},{"key":"58261_CR21","doi-asserted-by":"crossref","unstructured":"McMahon, S. B. & Priestley, J. V. Nociceptor plasticity. In: Hunt, S. P. & Koltzenburg, M., editors. Oxford Univ Press. The Neurobiology of Pain, 35\u201364 (2005).","DOI":"10.1093\/acprof:oso\/9780198515616.003.0002"},{"key":"58261_CR22","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/0014-5793(83)80033-7","volume":"164","author":"K Tatemoto","year":"1983","unstructured":"Tatemoto, K., Rokaeus, A., Jornvall, H., McDonald, T. J. & Mutt, V. Galanin - a novel biologically active peptide from porcine intestine. FEBS letters 164, 124\u2013128 (1983).","journal-title":"FEBS letters"},{"key":"58261_CR23","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/0306-4522(89)90411-9","volume":"33","author":"MJ Villar","year":"1989","unstructured":"Villar, M. J. et al. Neuropeptide expression in rat dorsal root ganglion cells and spinal cord after peripheral nerve injury with special reference to galanin. Neuroscience 33, 587\u2013604 (1989).","journal-title":"Neuroscience"},{"key":"58261_CR24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/978-1-4419-1399-9_12","volume":"664","author":"M Kaneda","year":"2010","unstructured":"Kaneda, M. et al. Growth-associated protein43 (GAP43) is a biochemical marker for the whole period of fish optic nerve regeneration. Advances in experimental medicine and biology 664, 97\u2013104, https:\/\/doi.org\/10.1007\/978-1-4419-1399-9_12 (2010).","journal-title":"Advances in experimental medicine and biology"},{"key":"58261_CR25","doi-asserted-by":"publisher","first-page":"4432","DOI":"10.1523\/JNEUROSCI.2245-02.2004","volume":"24","author":"WB Cafferty","year":"2004","unstructured":"Cafferty, W. B. et al. Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice. The Journal of neuroscience: the official journal of the Society for Neuroscience 24, 4432\u20134443, https:\/\/doi.org\/10.1523\/JNEUROSCI.2245-02.2004 (2004).","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"58261_CR26","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1002\/glia.22570","volume":"61","author":"I Dey","year":"2013","unstructured":"Dey, I. et al. Diabetic Schwann cells suffer from nerve growth factor and neurotrophin-3 underproduction and poor associability with axons. Glia 61, 1990\u20131999, https:\/\/doi.org\/10.1002\/glia.22570 (2013).","journal-title":"Glia"},{"key":"58261_CR27","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1159\/000217901","volume":"15","author":"BS Mitchell","year":"1994","unstructured":"Mitchell, B. S., Schumacher, U. & Kaiserling, E. Are tumours innervated? Immunohistological investigations using antibodies against the neuronal marker protein gene product 9.5 (PGP 9.5) in benign, malignant and experimental tumours. Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine 15, 269\u2013274 (1994).","journal-title":"Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine"},{"key":"58261_CR28","doi-asserted-by":"publisher","first-page":"e79523","DOI":"10.1371\/journal.pone.0079523","volume":"8","author":"S Manteniotis","year":"2013","unstructured":"Manteniotis, S. et al. Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia. PloS one 8, e79523, https:\/\/doi.org\/10.1371\/journal.pone.0079523 (2013).","journal-title":"PloS one"},{"key":"58261_CR29","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/ncb2274","volume":"13","author":"T Ishiuchi","year":"2011","unstructured":"Ishiuchi, T. & Takeichi, M. Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Nature cell biology 13, 860\u2013866, https:\/\/doi.org\/10.1038\/ncb2274 (2011).","journal-title":"Nature cell biology"},{"key":"58261_CR30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1242\/dev.045500","volume":"138","author":"G Halder","year":"2011","unstructured":"Halder, G. & Johnson, R. L. Hippo signaling: growth control and beyond. Development 138, 9\u201322, https:\/\/doi.org\/10.1242\/dev.045500 (2011).","journal-title":"Development"},{"key":"58261_CR31","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/ncb2303","volume":"13","author":"B Zhao","year":"2011","unstructured":"Zhao, B., Tumaneng, K. & Guan, K. L. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nature cell biology 13, 877\u2013883, https:\/\/doi.org\/10.1038\/ncb2303 (2011).","journal-title":"Nature cell biology"},{"key":"58261_CR32","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1101\/gad.210773.112","volume":"27","author":"FX Yu","year":"2013","unstructured":"Yu, F. X. & Guan, K. L. The Hippo pathway: regulators and regulations. Genes & development 27, 355\u2013371, https:\/\/doi.org\/10.1101\/gad.210773.112 (2013).","journal-title":"Genes & development"},{"key":"58261_CR33","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nrc2070","volume":"7","author":"K Harvey","year":"2007","unstructured":"Harvey, K. & Tapon, N. The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nature reviews. Cancer 7, 182\u2013191, https:\/\/doi.org\/10.1038\/nrc2070 (2007).","journal-title":"Nature reviews. Cancer"},{"key":"58261_CR34","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1038\/onc.2012.196","volume":"32","author":"S Moleirinho","year":"2013","unstructured":"Moleirinho, S. et al. KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals. Oncogene 32, 1821\u20131830, https:\/\/doi.org\/10.1038\/onc.2012.196 (2013).","journal-title":"Oncogene"},{"key":"58261_CR35","doi-asserted-by":"publisher","first-page":"10128","DOI":"10.1523\/JNEUROSCI.0800-16.2016","volume":"36","author":"N Xu","year":"2016","unstructured":"Xu, N. et al. Inhibition of YAP\/TAZ Activity in Spinal Cord Suppresses Neuropathic Pain. The Journal of neuroscience: the official journal of the Society for Neuroscience 36, 10128\u201310140, https:\/\/doi.org\/10.1523\/JNEUROSCI.0800-16.2016 (2016).","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"58261_CR36","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/s00221-001-0929-0","volume":"142","author":"A McKay Hart","year":"2002","unstructured":"McKay Hart, A., Brannstrom, T., Wiberg, M. & Terenghi, G. Primary sensory neurons and satellite cells after peripheral axotomy in the adult rat: timecourse of cell death and elimination. Experimental brain research 142, 308\u2013318, https:\/\/doi.org\/10.1007\/s00221-001-0929-0 (2002).","journal-title":"Experimental brain research"},{"key":"58261_CR37","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0006-8993(85)90590-6","volume":"332","author":"A Tessler","year":"1985","unstructured":"Tessler, A., Himes, B. T., Krieger, N. R., Murray, M. & Goldberger, M. E. Sciatic nerve transection produces death of dorsal root ganglion cells and reversible loss of substance P in spinal cord. Brain research 332, 209\u2013218 (1985).","journal-title":"Brain research"},{"key":"58261_CR38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0006-8993(86)90310-0","volume":"373","author":"J Arvidsson","year":"1986","unstructured":"Arvidsson, J., Ygge, J. & Grant, G. Cell loss in lumbar dorsal root ganglia and transganglionic degeneration after sciatic nerve resection in the rat. Brain research 373, 15\u201321 (1986).","journal-title":"Brain research"},{"key":"58261_CR39","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0306-4522(01)00148-8","volume":"105","author":"TJ Shi","year":"2001","unstructured":"Shi, T. J. et al. Effect of peripheral nerve injury on dorsal root ganglion neurons in the C57 BL\/6J mouse: marked changes both in cell numbers and neuropeptide expression. Neuroscience 105, 249\u2013263 (2001).","journal-title":"Neuroscience"},{"key":"58261_CR40","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1101\/gad.1909210","volume":"24","author":"B Zhao","year":"2010","unstructured":"Zhao, B., Li, L., Lei, Q. & Guan, K. L. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes & development 24, 862\u2013874, https:\/\/doi.org\/10.1101\/gad.1909210 (2010).","journal-title":"Genes & development"},{"key":"58261_CR41","first-page":"39","volume":"102","author":"XJ Xu","year":"2010","unstructured":"Xu, X. J., Hokfelt, T. & Wiesenfeld-Hallin, Z. Galanin and spinal pain mechanisms: past, present, and future. Exs 102, 39\u201350 (2010).","journal-title":"Exs"},{"key":"58261_CR42","first-page":"25","volume":"102","author":"SA Hobson","year":"2010","unstructured":"Hobson, S. A. et al. Galanin acts as a trophic factor to the central and peripheral nervous systems. Exs 102, 25\u201338 (2010).","journal-title":"Exs"},{"key":"58261_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-3-16","volume":"3","author":"M Costigan","year":"2002","unstructured":"Costigan, M. et al. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC neuroscience 3, 16 (2002).","journal-title":"BMC neuroscience"},{"key":"58261_CR44","doi-asserted-by":"publisher","first-page":"8360","DOI":"10.1073\/pnas.122231899","volume":"99","author":"HS Xiao","year":"2002","unstructured":"Xiao, H. S. et al. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America 99, 8360\u20138365, https:\/\/doi.org\/10.1073\/pnas.122231899 (2002).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"58261_CR45","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nature05453","volume":"445","author":"ES Lein","year":"2007","unstructured":"Lein, E. S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168\u2013176, https:\/\/doi.org\/10.1038\/nature05453 (2007).","journal-title":"Nature"},{"key":"58261_CR46","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.brainres.2013.08.049","volume":"1535","author":"N Li","year":"2013","unstructured":"Li, N. et al. Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats. Brain research 1535, 137\u2013147, https:\/\/doi.org\/10.1016\/j.brainres.2013.08.049 (2013).","journal-title":"Brain research"},{"key":"58261_CR47","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum, A. I., Bautista, D. M., Scherrer, G. & Julius, D. Cellular and molecular mechanisms of pain. Cell 139, 267\u2013284, https:\/\/doi.org\/10.1016\/j.cell.2009.09.028 (2009).","journal-title":"Cell"},{"key":"58261_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/nbdi.2000.0360","volume":"8","author":"RR Ji","year":"2001","unstructured":"Ji, R. R. & Woolf, C. J. Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiology of disease 8, 1\u201310, https:\/\/doi.org\/10.1006\/nbdi.2000.0360 (2001).","journal-title":"Neurobiology of disease"},{"key":"58261_CR49","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/j.1460-9568.2010.07351.x","volume":"32","author":"XJ Liu","year":"2010","unstructured":"Liu, X. J. & Salter, M. W. Glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn. The European journal of neuroscience 32, 278\u2013289, https:\/\/doi.org\/10.1111\/j.1460-9568.2010.07351.x (2010).","journal-title":"The European journal of neuroscience"},{"key":"58261_CR50","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/978-3-662-46450-2_9","volume":"227","author":"AJ Todd","year":"2015","unstructured":"Todd, A. J. Plasticity of inhibition in the spinal cord. Handbook of experimental pharmacology 227, 171\u2013190, https:\/\/doi.org\/10.1007\/978-3-662-46450-2_9 (2015).","journal-title":"Handbook of experimental pharmacology"},{"key":"58261_CR51","doi-asserted-by":"publisher","first-page":"349","DOI":"10.2147\/JPR.S120092","volume":"10","author":"R Lynds","year":"2017","unstructured":"Lynds, R. et al. Neuronal plasticity of trigeminal ganglia in mice following nerve injury. Journal of pain research 10, 349\u2013357, https:\/\/doi.org\/10.2147\/JPR.S120092 (2017).","journal-title":"Journal of pain research"},{"key":"58261_CR52","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1006\/mcne.1999.0814","volume":"15","author":"H Tsujino","year":"2000","unstructured":"Tsujino, H. et al. Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: A novel neuronal marker of nerve injury. Molecular and cellular neurosciences 15, 170\u2013182, https:\/\/doi.org\/10.1006\/mcne.1999.0814 (2000).","journal-title":"Molecular and cellular neurosciences"},{"key":"58261_CR53","doi-asserted-by":"crossref","first-page":"15819","DOI":"10.1016\/S0021-9258(17)40754-X","volume":"269","author":"BP Chen","year":"1994","unstructured":"Chen, B. P., Liang, G., Whelan, J. & Hai, T. ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. The Journal of biological chemistry 269, 15819\u201315826 (1994).","journal-title":"The Journal of biological chemistry"},{"key":"58261_CR54","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1073\/pnas.88.9.3720","volume":"88","author":"T Hai","year":"1991","unstructured":"Hai, T. & Curran, T. Cross-family dimerization of transcription factors Fos\/Jun and ATF\/CREB alters DNA binding specificity. Proceedings of the National Academy of Sciences of the United States of America 88, 3720\u20133724 (1991).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"58261_CR55","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1210\/mend.8.1.8152431","volume":"8","author":"HM Chu","year":"1994","unstructured":"Chu, H. M., Tan, Y., Kobierski, L. A., Balsam, L. B. & Comb, M. J. Activating transcription factor-3 stimulates 3\u2032,5\u2032-cyclic adenosine monophosphate-dependent gene expression. Molecular endocrinology 8, 59\u201368, https:\/\/doi.org\/10.1210\/mend.8.1.8152431 (1994).","journal-title":"Molecular endocrinology"},{"key":"58261_CR56","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.2147\/JPR.S133087","volume":"10","author":"C Lyu","year":"2017","unstructured":"Lyu, C., Lyu, G. W., Martinez, A. & Shi, T. S. Effect of nerve injury on the number of dorsal root ganglion neurons and autotomy behavior in adult Bax-deficient mice. Journal of pain research 10, 2079\u20132087, https:\/\/doi.org\/10.2147\/JPR.S133087 (2017).","journal-title":"Journal of pain research"},{"key":"58261_CR57","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1097\/00000542-199111000-00020","volume":"75","author":"J Katz","year":"1991","unstructured":"Katz, J., Vaccarino, A. L., Coderre, T. J. & Melzack, R. Injury prior to neurectomy alters the pattern of autotomy in rats. Behavioral evidence of central neural plasticity. Anesthesiology 75, 876\u2013883, https:\/\/doi.org\/10.1097\/00000542-199111000-00020 (1991).","journal-title":"Behavioral evidence of central neural plasticity. Anesthesiology"},{"key":"58261_CR58","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.neuroscience.2006.02.009","volume":"140","author":"TJ Shi","year":"2006","unstructured":"Shi, T. J. et al. Deletion of the neuropeptide Y Y1 receptor affects pain sensitivity, neuropeptide transport and expression, and dorsal root ganglion neuron numbers. Neuroscience 140, 293\u2013304, https:\/\/doi.org\/10.1016\/j.neuroscience.2006.02.009 (2006).","journal-title":"Neuroscience"},{"key":"58261_CR59","doi-asserted-by":"publisher","first-page":"20004","DOI":"10.1073\/pnas.0810899105","volume":"105","author":"TJ Shi","year":"2008","unstructured":"Shi, T. J. et al. Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America 105, 20004\u201320008, https:\/\/doi.org\/10.1073\/pnas.0810899105 (2008).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"58261_CR60","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-714","volume":"7","author":"U Bala","year":"2014","unstructured":"Bala, U., Tan, K. L., Ling, K. H. & Cheah, P. S. Harvesting the maximum length of sciatic nerve from adult mice: a step-by-step approach. BMC research notes 7, 714, https:\/\/doi.org\/10.1186\/1756-0500-7-714 (2014).","journal-title":"BMC research notes"},{"key":"58261_CR61","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1159\/000210400","volume":"17","author":"TJ Shi","year":"2009","unstructured":"Shi, T. J., Huang, P., Mulder, J., Ceccatelli, S. & Hokfelt, T. Expression of p-Akt in sensory neurons and spinal cord after peripheral nerve injury. Neuro-Signals 17, 203\u2013212, https:\/\/doi.org\/10.1159\/000210400 (2009).","journal-title":"Neuro-Signals"},{"key":"58261_CR62","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/0306-4522(94)90387-5","volume":"62","author":"H Wang","year":"1994","unstructured":"Wang, H., Rivero-Melian, C., Robertson, B. & Grant, G. Transganglionic transport and binding of the isolectin B4 from Griffonia simplicifolia I in rat primary sensory neurons. Neuroscience 62, 539\u2013551 (1994).","journal-title":"Neuroscience"},{"key":"58261_CR63","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402\u2013408, https:\/\/doi.org\/10.1006\/meth.2001.1262 (2001).","journal-title":"Methods"},{"key":"58261_CR64","doi-asserted-by":"publisher","DOI":"10.1186\/s12990-015-0044-z","volume":"11","author":"C Lyu","year":"2015","unstructured":"Lyu, C. et al. G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy. Molecular pain 11, 44, https:\/\/doi.org\/10.1186\/s12990-015-0044-z (2015).","journal-title":"Molecular pain"},{"key":"58261_CR65","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-8-80","volume":"8","author":"TJ Shi","year":"2012","unstructured":"Shi, T. J. et al. Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human. Molecular pain 8, 80, https:\/\/doi.org\/10.1186\/1744-8069-8-80 (2012).","journal-title":"Molecular pain"},{"key":"58261_CR66","doi-asserted-by":"publisher","first-page":"22296","DOI":"10.1073\/pnas.1013413108","volume":"107","author":"G Scherrer","year":"2010","unstructured":"Scherrer, G. et al. VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proceedings of the National Academy of Sciences of the United States of America 107, 22296\u201322301, https:\/\/doi.org\/10.1073\/pnas.1013413108 (2010).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-58261-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-58261-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-58261-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T09:44:27Z","timestamp":1672652667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-58261-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,5]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["58261"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-58261-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,5]]},"assertion":[{"value":"22 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1880"}}