{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:49:48Z","timestamp":1787863788955,"version":"build-2784847793"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["Dnr. 2015-02844"],"award-info":[{"award-number":["Dnr. 2015-02844"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 2018\/801"],"award-info":[{"award-number":["CAN 2018\/801"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 2015\/694"],"award-info":[{"award-number":["CAN 2015\/694"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous Squamous Cell Carcinoma (cSCC) is the most common and fastest-increasing cancer with metastatic potential. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are novel regulators of gene expression. To identify mRNAs, lncRNAs and circRNAs, which can be involved in cSCC, RNA-seq was performed on nine cSCCs and seven healthy skin samples. Representative transcripts were validated by NanoString nCounter assays using an extended cohort, which also included samples from\u00a0pre-cancerous\u00a0skin lesions (actinic keratosis). 5,352 protein-coding genes, 908 lncRNAs and 55 circular RNAs were identified\u00a0to be differentially expressed in cSCC. Targets of 519 transcription factors were enriched among differentially expressed genes, 105 of which displayed altered level in cSCCs, including fundamental regulators of skin development (MYC, RELA, ETS1, TP63). Pathways related to cell cycle, apoptosis, inflammation and epidermal differentiation were enriched. In addition to known oncogenic lncRNAs (PVT1, LUCAT1, CASC9), a set of skin-specific lncRNAs were were identified to be dysregulated. A global downregulation of circRNAs was observed in cSCC, and novel skin-enriched\u00a0circRNAs,\u00a0circ_IFFO2 and circ_POF1B, were identified and validated. In conclusion, a reference set of coding and non-coding transcripts were identified in cSCC, which may become potential therapeutic targets or biomarkers.<\/jats:p>","DOI":"10.1038\/s41598-020-59660-6","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T11:04:32Z","timestamp":1582801472000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma"],"prefix":"10.1038","volume":"10","author":[{"given":"Kunal","family":"Das Mahapatra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Pasquali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4438-6756","authenticated-orcid":false,"given":"Jonas N\u00f8rskov","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lapins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n Balazs","family":"Nemeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Balt\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2119-9501","authenticated-orcid":false,"given":"Lajos","family":"Kem\u00e9ny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Homey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liviu-Ionut","family":"Moldovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Kjems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Kutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u00f6","family":"Sonkoly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5980-7939","authenticated-orcid":false,"given":"Lasse Sommer","family":"Kristensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-1102","authenticated-orcid":false,"given":"Andor","family":"Pivarcsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"59660_CR1","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.jaad.2012.11.037","volume":"68","author":"PS Karia","year":"2013","unstructured":"Karia, P. S., Han, J. & Schmults, C. D. Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. J. Am. Acad. Dermatol. 68, 957\u2013966 (2013).","journal-title":"J. Am. Acad. Dermatol."},{"key":"59660_CR2","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1056\/NEJM200103293441306","volume":"344","author":"M Alam","year":"2001","unstructured":"Alam, M. & Ratner, D. Cutaneous squamous-cell carcinoma. N. Engl. J. Med. 344, 975\u2013983 (2001).","journal-title":"N. Engl. J. Med."},{"key":"59660_CR3","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jaad.2017.08.059","volume":"78","author":"SKT Que","year":"2018","unstructured":"Que, S. K. T., Zwald, F. O. & Schmults, C. D. Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging. J. Am. Acad. Dermatology 78, 237\u2013247 (2018).","journal-title":"J. Am. Acad. Dermatology"},{"key":"59660_CR4","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.ejca.2015.06.110","volume":"51","author":"A Stratigos","year":"2015","unstructured":"Stratigos, A. et al. Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline. Eur. J. Cancer 51, 1989\u20132007 (2015).","journal-title":"Eur. J. Cancer"},{"key":"59660_CR5","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1172\/JCI57415","volume":"122","author":"V Ratushny","year":"2012","unstructured":"Ratushny, V., Gober, M. D., Hick, R., Ridky, T. W. & Seykora, J. T. From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J. Clin. Invest. 122, 464\u2013472 (2012).","journal-title":"J. Clin. Invest."},{"key":"59660_CR6","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1158\/1078-0432.CCR-14-1773","volume":"21","author":"YY Li","year":"2015","unstructured":"Li, Y. Y. et al. Genomic Analysis of Metastatic Cutaneous Squamous Cell Carcinoma. Clin. Cancer Res. 21, 1447\u20131456 (2015).","journal-title":"Clin. Cancer Res."},{"key":"59660_CR7","doi-asserted-by":"crossref","unstructured":"Chitsazzadeh, V. et al. Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates. Nature Communications 7 (2016).","DOI":"10.1038\/ncomms12601"},{"key":"59660_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-58","volume":"13","author":"L Hameetman","year":"2013","unstructured":"Hameetman, L. et al. Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients. BMC Cancer 13, 58 (2013).","journal-title":"BMC Cancer"},{"key":"59660_CR9","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1101\/gr.132159.111","volume":"22","author":"T Derrien","year":"2012","unstructured":"Derrien, T. et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 22, 1775\u20131789 (2012).","journal-title":"Genome Res."},{"key":"59660_CR10","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1073\/pnas.0706729105","volume":"105","author":"TR Mercer","year":"2008","unstructured":"Mercer, T. R., Dinger, M. E., Sunkin, S. M., Mehler, M. F. & Mattick, J. S. Specific expression of long noncoding RNAs in the mouse brain. Proc. Natl. Acad. Sci. USA 105, 716\u2013721 (2008).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"59660_CR11","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1038\/nm.3981","volume":"21","author":"M Huarte","year":"2015","unstructured":"Huarte, M. The emerging role of lncRNAs in cancer. Nat. Med. 21, 1253\u20131261 (2015).","journal-title":"Nat. Med."},{"key":"59660_CR12","first-page":"984","volume":"18","author":"S Xia","year":"2017","unstructured":"Xia, S. et al. Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Brief. Bioinforma. 18, 984\u2013992 (2017).","journal-title":"Brief. Bioinforma."},{"key":"59660_CR13","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s00018-017-2688-5","volume":"75","author":"LM Holdt","year":"2018","unstructured":"Holdt, L. M., Kohlmaier, A. & Teupser, D. Molecular roles and function of circular RNAs in eukaryotic cells. Cell. Mol. Life Sci. 75, 1071\u20131098 (2018).","journal-title":"Cell. Mol. Life Sci."},{"key":"59660_CR14","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/onc.2017.361","volume":"37","author":"LS Kristensen","year":"2018","unstructured":"Kristensen, L. S., Hansen, T. B., Ven\u00f8, M. T. & Kjems, J. Circular RNAs in cancer: opportunities and challenges in the field. Oncogene 37, 555\u2013565 (2018).","journal-title":"Oncogene"},{"key":"59660_CR15","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.1038\/onc.2010.159","volume":"29","author":"Y Xu","year":"2010","unstructured":"Xu, Y., Yan, W. & Chen, X. SNF5, a core component of the Swi\/Snf complex, is necessary for p53 expression and cell survival in part via eIF4E. Oncogene 29, 4090\u20134100 (2010).","journal-title":"Oncogene"},{"key":"59660_CR16","doi-asserted-by":"publisher","first-page":"3566","DOI":"10.1242\/jcs.062240","volume":"123","author":"P Nagarajan","year":"2010","unstructured":"Nagarajan, P. et al. Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators. J. Cell Sci. 123, 3566\u20133575 (2010).","journal-title":"J. Cell Sci."},{"key":"59660_CR17","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/cdd.2008.69","volume":"15","author":"AM Lena","year":"2008","unstructured":"Lena, A. M. et al. miR-203 represses \u2018stemness\u2019 by repressing DeltaNp63. Cell Death Differ. 15, 1187\u20131195 (2008).","journal-title":"Cell Death Differ."},{"key":"59660_CR18","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.devcel.2011.12.001","volume":"22","author":"GL Sen","year":"2012","unstructured":"Sen, G. L. et al. ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. Dev. Cell 22, 669\u2013677 (2012).","journal-title":"Dev. Cell"},{"key":"59660_CR19","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1073\/pnas.93.1.274","volume":"93","author":"RJ Berg","year":"1996","unstructured":"Berg, R. J. et al. Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells. Proc. Natl Acad. Sci. USA 93, 274\u2013278 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"59660_CR20","doi-asserted-by":"publisher","first-page":"8858","DOI":"10.1073\/pnas.95.15.8858","volume":"95","author":"AM Pierce","year":"1998","unstructured":"Pierce, A. M. et al. Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53. PNAS 95, 8858\u20138863 (1998).","journal-title":"PNAS"},{"key":"59660_CR21","first-page":"259","volume":"26","author":"LM Alvarez-Salas","year":"2005","unstructured":"Alvarez-Salas, L. M., Benitez-Hess, M. L. & Dipaolo, J. A. YY-1 and c-Jun transcription factors participate in the repression of the human involucrin promoter. Int. J. Oncol. 26, 259\u2013266 (2005).","journal-title":"Int. J. Oncol."},{"key":"59660_CR22","doi-asserted-by":"crossref","first-page":"34371","DOI":"10.18632\/oncotarget.9110","volume":"7","author":"X Zhang","year":"2016","unstructured":"Zhang, X., Wu, J., Luo, S., Lechler, T. & Zhang, J. Y. FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms. Oncotarget 7, 34371\u201334383 (2016).","journal-title":"Oncotarget"},{"key":"59660_CR23","doi-asserted-by":"publisher","first-page":"970","DOI":"10.15252\/emmm.201303541","volume":"6","author":"C Kim","year":"2014","unstructured":"Kim, C. & Pasparakis, M. Epidermal p65\/NF-\u03baB signalling is essential for skin carcinogenesis. EMBO Mol. Med. 6, 970\u2013983 (2014).","journal-title":"EMBO Mol. Med."},{"key":"59660_CR24","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1101\/gad.17446611","volume":"25","author":"MN Cabili","year":"2011","unstructured":"Cabili, M. N. et al. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes. Dev. 25, 1915\u20131927 (2011).","journal-title":"Genes. Dev."},{"key":"59660_CR25","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.biopha.2018.09.025","volume":"108","author":"B Jiang","year":"2018","unstructured":"Jiang, B. et al. Identification of oncogenic long noncoding RNA SNHG12 and DUXAP8 in human bladder cancer through a comprehensive profiling analysis. Biomedicine Pharmacotherapy 108, 500\u2013507 (2018).","journal-title":"Biomedicine Pharmacotherapy"},{"key":"59660_CR26","doi-asserted-by":"crossref","first-page":"113622","DOI":"10.18632\/oncotarget.21185","volume":"8","author":"H Xiao","year":"2017","unstructured":"Xiao, H. et al. Long non-coding RNA Lucat1 is a poor prognostic factor and demonstrates malignant biological behavior in clear cell renal cell carcinoma. Oncotarget 8, 113622\u2013113634 (2017).","journal-title":"Oncotarget"},{"key":"59660_CR27","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1002\/cam4.770","volume":"5","author":"Z Pan","year":"2016","unstructured":"Pan, Z. et al. The long noncoding RNA CASC9 regulates migration and invasion in esophageal cancer. Cancer Med. 5, 2442\u20132447 (2016).","journal-title":"Cancer Med."},{"key":"59660_CR28","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/nature13311","volume":"512","author":"Y-Y Tseng","year":"2014","unstructured":"Tseng, Y.-Y. et al. PVT1 dependence in cancer with MYC copy-number increase. Nat. 512, 82\u201386 (2014).","journal-title":"Nat."},{"key":"59660_CR29","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1126\/science.1262110","volume":"348","author":"T Consortium","year":"2015","unstructured":"Consortium, T. Gte. The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans. Sci. 348, 648\u2013660 (2015).","journal-title":"Sci."},{"key":"59660_CR30","doi-asserted-by":"publisher","first-page":"e78179","DOI":"10.1371\/journal.pone.0078179","volume":"8","author":"JM Rozenberg","year":"2013","unstructured":"Rozenberg, J. M., Bhattacharya, P., Chatterjee, R., Glass, K. & Vinson, C. Combinatorial Recruitment of CREB, C\/EBP\u03b2 and c-Jun Determines Activation of Promoters upon Keratinocyte Differentiation. PLOS ONE 8, e78179 (2013).","journal-title":"PLOS ONE"},{"key":"59660_CR31","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1600-0625.2006.00528.x","volume":"16","author":"Y Nakamura","year":"2007","unstructured":"Nakamura, Y. et al. The combination of ubiquitous transcription factors AP-1 and Sp1 directs keratinocyte-specific and differentiation-specific gene expression in vitro. Exp. Dermatol. 16, 143\u2013150 (2007).","journal-title":"Exp. Dermatol."},{"key":"59660_CR32","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1080\/15476286.2017.1409931","volume":"15","author":"LS Kristensen","year":"2018","unstructured":"Kristensen, L. S., Okholm, T. L. H., Ven\u00f8, M. T. & Kjems, J. Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation. RNA Biol. 15, 280\u2013291 (2018).","journal-title":"RNA Biol."},{"key":"59660_CR33","doi-asserted-by":"crossref","unstructured":"Stagsted, L. V., Nielsen, K. M., Daugaard, I. & Hansen, T. B. Noncoding AUG circRNAs constitutean abundant and conserved subclass of circles. Life Sci Alliance 2, (2019).","DOI":"10.26508\/lsa.201900398"},{"key":"59660_CR34","doi-asserted-by":"publisher","first-page":"5609","DOI":"10.1158\/0008-5472.CAN-13-1568","volume":"73","author":"TB Hansen","year":"2013","unstructured":"Hansen, T. B., Kjems, J. & Damgaard, C. K. Circular RNA and miR-7 in Cancer. Cancer Res. 73, 5609\u20135612 (2013).","journal-title":"Cancer Res."},{"key":"59660_CR35","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1038\/s41374-018-0108-6","volume":"98","author":"M Dahl","year":"2018","unstructured":"Dahl, M. et al. Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies. Lab. Invest. 98, 1657\u20131669 (2018).","journal-title":"Lab. Invest."},{"key":"59660_CR36","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1111\/j.1365-2133.2009.09338.x","volume":"161","author":"RV Haren","year":"2009","unstructured":"Haren, R. V., Feldman, D. & Sinha, A. A. Systematic comparison of nonmelanoma skin cancer microarray datasets reveals lack of consensus genes. Br. J. Dermatology 161, 1278\u20131287 (2009).","journal-title":"Br. J. Dermatology"},{"key":"59660_CR37","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0065-230X(10)06003-3","volume":"106","author":"EC Keeley","year":"2010","unstructured":"Keeley, E. C., Mehrad, B. & Strieter, R. M. CXC Chemokines in Cancer Angiogenesis and Metastases. Adv. Cancer Res. 106, 91\u2013111 (2010).","journal-title":"Adv. Cancer Res."},{"key":"59660_CR38","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1158\/2326-6066.CIR-14-0160","volume":"2","author":"MT Chow","year":"2014","unstructured":"Chow, M. T. & Luster, A. D. Chemokines in Cancer. Cancer Immunol. Res. 2, 1125\u20131131 (2014).","journal-title":"Cancer Immunol. Res."},{"key":"59660_CR39","doi-asserted-by":"publisher","first-page":"19055","DOI":"10.1073\/pnas.0705673104","volume":"104","author":"A Pivarcsi","year":"2007","unstructured":"Pivarcsi, A. et al. Tumor immune escape by the loss of homeostatic chemokine expression. PNAS 104, 19055\u201319060 (2007).","journal-title":"PNAS"},{"key":"59660_CR40","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jid.2016.07.033","volume":"137","author":"Z Jian","year":"2017","unstructured":"Jian, Z., Strait, A., Jimeno, A. & Wang, X.-J. Cancer Stem Cells in Squamous Cell Carcinoma. J. Invest. Dermatol. 137, 31\u201337 (2017).","journal-title":"J. Invest. Dermatol."},{"key":"59660_CR41","doi-asserted-by":"crossref","unstructured":"Nagarajan, P., Parikh, N., Garrett-Sinha, L. A. & Sinha, S. Ets1 Induces Dysplastic Changes When Expressed in Terminally-Differentiating Squamous Epidermal Cells. PLoS One 4 (2009).","DOI":"10.1371\/journal.pone.0004179"},{"key":"59660_CR42","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.cell.2006.07.036","volume":"127","author":"H Nguyen","year":"2006","unstructured":"Nguyen, H., Rendl, M. & Fuchs, E. Tcf3 governs stem cell features and represses cell fate determination in skin. Cell 127, 171\u2013183 (2006).","journal-title":"Cell"},{"key":"59660_CR43","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1038\/s41388-017-0032-z","volume":"37","author":"N Tanaka","year":"2018","unstructured":"Tanaka, N. et al. Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1. Oncogene 37, 1279 (2018).","journal-title":"Oncogene"},{"issue":"5","key":"59660_CR44","doi-asserted-by":"publisher","first-page":"e1004309","DOI":"10.1371\/journal.pgen.1004309","volume":"10","author":"Amine Bouafia","year":"2014","unstructured":"Bouafia, A. et al. p53 Requires the Stress Sensor USF1 to Direct Appropriate Cell Fate Decision. PLoS Genet 10 (2014).","journal-title":"PLoS Genetics"},{"key":"59660_CR45","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/ni.1944","volume":"11","author":"MF Nold","year":"2010","unstructured":"Nold, M. F. et al. IL-37 is a fundamental inhibitor of innate immunity. Nat. Immunology 11, 1014\u20131022 (2010).","journal-title":"Nat. Immunology"},{"key":"59660_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms7967","volume":"6","author":"M Montes","year":"2015","unstructured":"Montes, M. et al. The lncRNA MIR31HG regulates p16 INK4A expression to modulate senescence. Nat. Commun. 6, 1\u201315 (2015).","journal-title":"Nat. Commun."},{"key":"59660_CR47","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0860-7","volume":"17","author":"X Wang","year":"2018","unstructured":"Wang, X. et al. The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68. Mol. Cancer 17, 110 (2018).","journal-title":"Mol. Cancer"},{"key":"59660_CR48","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1016\/j.jid.2016.03.028","volume":"136","author":"M Piipponen","year":"2016","unstructured":"Piipponen, M. et al. Long Noncoding RNA PICSAR Promotes Growth of Cutaneous Squamous Cell Carcinoma by Regulating ERK1\/2 Activity. J. Invest. Dermatol. 136, 1701\u20131710 (2016).","journal-title":"J. Invest. Dermatol."},{"key":"59660_CR49","doi-asserted-by":"publisher","first-page":"501","DOI":"10.2217\/epi-2015-0012","volume":"8","author":"M Sand","year":"2016","unstructured":"Sand, M. et al. Expression profiles of long noncoding RNAs in cutaneous squamous cell carcinoma. Epigenomics 8, 501\u2013518 (2016).","journal-title":"Epigenomics"},{"key":"59660_CR50","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature11661","volume":"493","author":"M Kretz","year":"2013","unstructured":"Kretz, M. et al. Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nat. 493, 231\u2013235 (2013).","journal-title":"Nat."},{"key":"59660_CR51","doi-asserted-by":"publisher","first-page":"3918","DOI":"10.1158\/1078-0432.CCR-16-2541","volume":"23","author":"W Weng","year":"2017","unstructured":"Weng, W. et al. Circular RNA ciRS-7-A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer. Clin. Cancer Res. 23, 3918\u20133928 (2017).","journal-title":"Clin. Cancer Res."},{"key":"59660_CR52","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/s41525-017-0038-z","volume":"2","author":"TLH Okholm","year":"2017","unstructured":"Okholm, T. L. H. et al. Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. NPJ Genom. Med. 2, 36 (2017).","journal-title":"NPJ Genom. Med."},{"key":"59660_CR53","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.556","volume":"8","author":"L Shi","year":"2017","unstructured":"Shi, L. et al. Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Cell Death Dis. 8, e3171 (2017).","journal-title":"Cell Death Dis."},{"key":"59660_CR54","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/febs.14191","volume":"285","author":"M Li","year":"2018","unstructured":"Li, M. et al. Biogenesis of circular RNAs and their roles in cardiovascular development and pathology. FEBS J. 285, 220\u2013232 (2018).","journal-title":"FEBS J."},{"key":"59660_CR55","doi-asserted-by":"publisher","DOI":"10.1038\/srep08057","volume":"5","author":"A Bachmayr-Heyda","year":"2015","unstructured":"Bachmayr-Heyda, A. et al. Correlation of circular RNA abundance with proliferation \u2013 exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues. Sci. Rep. 5, 8057 (2015).","journal-title":"Sci. Rep."},{"key":"59660_CR56","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.cell.2018.05.022","volume":"174","author":"B Kleaveland","year":"2018","unstructured":"Kleaveland, B., Shi, C. Y., Stefano, J. & Bartel, D. P. A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Cell 174, 350\u2013362.e17 (2018).","journal-title":"Cell"},{"key":"59660_CR57","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.2353\/ajpath.2010.090648","volume":"176","author":"M de Neergaard","year":"2010","unstructured":"de Neergaard, M. et al. Epithelial-Stromal Interaction 1 (EPSTI1) Substitutes for Peritumoral Fibroblasts in the Tumor Microenvironment. Am. J. Pathol. 176, 1229\u20131240 (2010).","journal-title":"Am. J. Pathol."},{"key":"59660_CR58","doi-asserted-by":"crossref","first-page":"61687","DOI":"10.18632\/oncotarget.18671","volume":"8","author":"H Zhang","year":"2017","unstructured":"Zhang, H. et al. Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression. Oncotarget 8, 61687\u201361697 (2017).","journal-title":"Oncotarget"},{"key":"59660_CR59","doi-asserted-by":"crossref","unstructured":"Huang, X.-Y. et al. Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338\/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. Sci Rep 7 (2017).","DOI":"10.1038\/s41598-017-05432-8"},{"key":"59660_CR60","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jdermsci.2016.05.012","volume":"83","author":"M Sand","year":"2016","unstructured":"Sand, M. et al. Circular RNA expression in cutaneous squamous cell carcinoma. J. Dermatol. Sci. 83, 210\u2013218 (2016).","journal-title":"J. Dermatol. Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-59660-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-59660-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-59660-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T07:21:52Z","timestamp":1670311312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-59660-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,27]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["59660"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-59660-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,27]]},"assertion":[{"value":"1 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3637"}}