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Here we determined changes in BIS-derived parameters and clinical signs of fluid overload from before to after abdominal paracentesis. Per our pre-specified sample size calculation, we studied 31 cirrhotic patients, analyzing demographics, labs and clinical parameters along with BIS results. Mean volume of the abdominal paracentesis was 7.8\u2009\u00b1\u20092.6\u2009L. From pre-to post-paracentesis, extracellular volume (ECV) decreased (20.2\u2009\u00b1\u20095.2\u2009L to 19.0\u2009\u00b1\u20094.8\u2009L), total body volume decreased (39.8\u2009\u00b1\u20099.8\u2009L to 37.8\u2009\u00b1\u20098.5\u2009L) and adipose tissue mass decreased (38.4\u2009\u00b1\u200916.0\u2009kg to 29.9\u2009\u00b1\u200912.9\u2009kg; all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009<jats:italic>0.002<\/jats:italic>). Correlation of BIS-derived parameters from pre to post-paracentesis ranged from R\u00b2\u2009=\u20090.26 for body cell mass to R\u00b2\u2009=\u20090.99 for ECV. Edema did not correlate with BIS-derived fluid overload (FO\u2009\u2265\u200915% ECV), which occurred in 16 patients (51.6%). In conclusion, BIS-derived information on fluid status did not coincide with clinical judgement. The changes in adipose tissue mass support the BIS-model assumption that fluid in the peritoneal cavity is not detectable, suggesting that ascites (or peritoneal dialysis fluid) mass should be subtracted from adipose tissue if BIS is used in patients with a full peritoneal cavity.<\/jats:p>","DOI":"10.1038\/s41598-020-59817-3","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T11:04:16Z","timestamp":1582023856000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bioimpedance spectroscopy for fluid status assessment in patients with decompensated liver cirrhosis: Implications for peritoneal dialysis"],"prefix":"10.1038","volume":"10","author":[{"given":"Elisabeth","family":"Schwaiger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrei","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Schairer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Berner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Signorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matth\u00e4us","family":"Ernstbrunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayko","family":"Evstatiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7183-8076","authenticated-orcid":false,"given":"Philipp","family":"Schwabl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Hinterholzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Frommlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Vychytil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Hecking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"59817_CR1","doi-asserted-by":"publisher","first-page":"S121","DOI":"10.1002\/hep.20993","volume":"43","author":"Y Iwakiri","year":"2006","unstructured":"Iwakiri, Y. & Groszmann, R. 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